Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Erik W. Settles"'
Autor:
Daniel R. Kollath, Francisca J. Grill, Ashley N. Itogawa, Ana Fabio-Braga, Matthew M. Morales, Kelly M. Shepardson, Mitchell L. Bryant, Jinhee Yi, Marieke L. Ramsey, Emily T. Luberto, Kimberly R. Celona, Paul S. Keim, Erik W. Settles, Douglas Lake, Bridget M. Barker
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-11 (2024)
Abstract Background Early reports showed that patients with COVID-19 had recrudescence of previously resolved coccidioidomycosis (Valley fever, VF), and there were indications that coinfection had more severe outcomes. We therefore investigated seria
Externí odkaz:
https://doaj.org/article/159c3eb0242249cba8121fd083805f5b
Autor:
Wenjuan Dong, Jing Wang, Lei Tian, Jianying Zhang, Erik W. Settles, Chao Qin, Daniel R. Steinken-Kollath, Ashley N. Itogawa, Kimberly R. Celona, Jinhee Yi, Mitchell Bryant, Heather Mead, Sierra A. Jaramillo, Hongjia Lu, Aimin Li, Ross E. Zumwalt, Sanjeet Dadwal, Pinghui Feng, Weiming Yuan, Sean P. J. Whelan, Paul S. Keim, Bridget Marie Barker, Michael A. Caligiuri, Jianhua Yu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
The serine protease factor Xa (FXa) is upregulated in COVID-19 patients and functions in the coagulation pathway. Here, Dong et al characterise the basis of its antiviral activity in the context of SARS-CoV-2 pandemic variants.
Externí odkaz:
https://doaj.org/article/b9e60e8540004b07b41e6a1c7eaa4a58
Autor:
Ting Lu, Rui Ma, Wenjuan Dong, Kun-Yu Teng, Daniel S. Kollath, Zhiyao Li, Jinhee Yi, Christian Bustillos, Shoubao Ma, Lei Tian, Anthony G. Mansour, Zhenlong Li, Erik W. Settles, Jianying Zhang, Paul S. Keim, Bridget M. Barker, Michael A. Caligiuri, Jianhua Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Severe COVID-19 requires immediate and targeted intervention that is efficient against SARS-CoV-2 and its variants. Authors show here the therapeutic potential of engineered natural killer cells that simultaneously express a chimeric antigen receptor
Externí odkaz:
https://doaj.org/article/a496bb02239944ea9f8d912347304051
Autor:
Erik W. Settles, Derek Sonderegger, Austin B. Shannon, Kimberly R. Celona, Rachel Lederer, Jinhee Yi, Courtney Seavey, Kyle Headley, Mimi Mbegbu, Maxx Harvey, Mitch Keener, Chris Allender, Heidie Hornstra, Fernando P. Monroy, Celeste Woerle, Vanessa Theobald, Mark Mayo, Bart J. Currie, Paul Keim
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 2 (2023)
Burkholderia pseudomallei, the causative agent of melioidosis, is a gram-negative soil bacterium well recognized in Southeast Asia and northern Australia. However, wider and expanding global distribution of B. pseudomallei has been elucidated. Early
Externí odkaz:
https://doaj.org/article/a8b275733925432b84fde5499424f85a
Autor:
Kimberly R. Celona, Austin B. Shannon, Derek Sonderegger, Jinhee Yi, Fernando P. Monroy, Christopher Allender, Heidie Hornstra, Mary B. Barnes, Elizabeth S. Didier, Rudolf P. Bohm, Kathrine Phillippi-Falkenstein, Daniel Sanford, Paul Keim, Erik W. Settles
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 2 (2023)
Background Melioidosis is a disease caused by the bacterium Burkholderia pseudomallei, infecting humans and non-human primates (NHP) through contaminated soil or water. World-wide there are an estimated 165,000 human melioidosis cases each year, but
Externí odkaz:
https://doaj.org/article/6eeeb6cc26b243debef04e286cd0ac95
Autor:
Evan A. Elko, Georgia A. Nelson, Heather L. Mead, Erin J. Kelley, Sophia T. Carvalho, Nathan G. Sarbo, Caroline E. Harms, Virginia Le Verche, Angelo A. Cardoso, Jennifer L. Ely, Annalee S. Boyle, Alejandra Piña, Sierra N. Henson, Fatima Rahee, Paul S. Keim, Kimberly R. Celona, Jinhee Yi, Erik W. Settles, Daniela A. Bota, George C. Yu, Sheldon R. Morris, John A. Zaia, Jason T. Ladner, John A. Altin
Publikováno v:
Cell Reports, Vol 40, Iss 1, Pp 111022- (2022)
Summary: The COVID-19 pandemic has triggered the first widespread vaccination campaign against a coronavirus. Many vaccinated subjects are previously naive to SARS-CoV-2; however, almost all have previously encountered other coronaviruses (CoVs), and
Externí odkaz:
https://doaj.org/article/f31c9ede1fc74a5a94d3651849a3547f
Autor:
Sarah M. Baker, Erik W. Settles, Christopher Davitt, Patrick Gellings, Nicole Kikendall, Joseph Hoffmann, Yihui Wang, Jacob Bitoun, Kasi-Russell Lodrigue, Jason W. Sahl, Paul Keim, Chad Roy, James McLachlan, Lisa A. Morici
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Burkholderia pseudomallei is a Gram-negative, facultative intracellular bacillus that causes the disease melioidosis. B. pseudomallei expresses a number of proteins that contribute to its intracellular survival in the mammalian host. We prev
Externí odkaz:
https://doaj.org/article/94ff28ca65e5414195014839c12c40a0
Autor:
Katherine E. Zarn, Sierra A. Jaramillo, Anthony R. Zapata, Nathan E. Stone, Ashley N. Jones, Haley E. Nunnally, Erik W. Settles, Ken Ng, Paul S. Keim, Steen Knudsen, Patricia M. Nuijten, Aloys S. L. Tijsma, Christopher T. French
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
We recently published a preliminary assessment of the activity of a poly (ADP-ribose) polymerase (PARP) inhibitor, stenoparib, also known as 2X-121, which inhibits viral replication by affecting pathways of the host. Here we show that stenoparib effe
Externí odkaz:
https://doaj.org/article/7f790e1a8dfb46e3a3c0fd70f52ee73b
Autor:
Nathan E. Stone, Sierra A. Jaramillo, Ashley N. Jones, Adam J. Vazquez, Madison Martz, Lora M. Versluis, Marlee O. Raniere, Haley E. Nunnally, Katherine E. Zarn, Roxanne Nottingham, Ken R. Ng, Jason W. Sahl, David M. Wagner, Steen Knudsen, Erik W. Settles, Paul Keim, Christopher T. French
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
New therapeutics are urgently needed in the fight against COVID-19. Repurposing drugs that are either already approved for human use or are in advanced stages of the approval process can facilitate more rapid advances toward this goal.
Externí odkaz:
https://doaj.org/article/620d821873f544a29175de77273152c9
Autor:
Jason W. Sahl, Lisa A. Morici, Chad J. Roy, Jacob P. Bitoun, Yihui Wang, Christopher Davitt, Sarah M. Baker, Joseph P. Hoffmann, James B. McLachlan, Nicole L. Kikendall, Kasi Russell Lodrigue, Paul Keim, Patrick S. Gellings, Erik W. Settles
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
NPJ Vaccines
NPJ Vaccines
Burkholderia pseudomallei is a Gram-negative, facultative intracellular bacillus that causes the disease melioidosis. B. pseudomallei expresses a number of proteins that contribute to its intracellular survival in the mammalian host. We previously de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d85605ccdd3876da9dfe95a7480ed88
https://doaj.org/article/94ff28ca65e5414195014839c12c40a0
https://doaj.org/article/94ff28ca65e5414195014839c12c40a0