Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Erik Vogan"'
Autor:
Zhong Li, Judy Lucas, Jonathan D. Bloom, Russell Dushin, Hao Liu, Mercy Otteng, Mark Johnson, Thomas Nittoli, Jeremy I. Levin, Andrea Olland, Jennifer M. Golas, Christoph W. Zapf, Erik Vogan, Antonia A. Nikitenko, Frank Boschelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4602-4607
An extension of our previously reported series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. Addition of a second methyl group to the tether provided analogs that show increased potency in binding as well as cell-proliferation ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292118865b349b233211d45dbcb33006
https://doi.org/10.1016/j.bmcl.2011.05.102
https://doi.org/10.1016/j.bmcl.2011.05.102
Autor:
Judy Lucas, Russell Dushin, Christoph W. Zapf, Jamie L. McBean, Hao Liu, Jennifer M. Golas, Frank Boschelli, Erik Vogan, Jeremy I. Levin, Jonathan D. Bloom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3627-3631
A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. In continuation of our research, heterocycle-containing tethers were explored with the intent to further improve potency and minimize hERG liabilities. This effort culmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4697a421ffa5a6182e3ba0584b4346
https://doi.org/10.1016/j.bmcl.2011.04.102
https://doi.org/10.1016/j.bmcl.2011.04.102
Autor:
Charles Ingalls, Christoph W. Zapf, Hao Liu, Thomas Nittoli, Judy Lucas, Erik Vogan, Jamie L. McBean, Russell Dushin, Mercy Otteng, Jeremy I. Levin, Frank Boschelli, Yongbo Hu, Jennifer M. Golas, Bloom Jonathan David
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3411-3416
A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. In continuation of our research in this area, macrocyclic amides and lactams were explored to reduce the risk of hERG liabilities. This effort culminated in the discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e86ec59ece02b676d71192cfd60f61
https://doi.org/10.1016/j.bmcl.2011.03.112
https://doi.org/10.1016/j.bmcl.2011.03.112
Autor:
Charles Ingalls, Yongbo Hu, Jeremy I. Levin, Jennifer M. Golas, Clark Eid, Jamie L. McBean, Russell Dushin, Hao Liu, Christoph W. Zapf, Erik Vogan, John P. Sonye, Jonathan D. Bloom, Thomas Nittoli, Alan G. Sutherland, Frank Boschelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2278-2282
A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. A basic nitrogen within the tether linking the aniline nitrogen atom to a tetrahydroindolone moiety allowed access to compounds with good physical properties. Important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabfd0f4263ef6a43713db09d489049c
https://doi.org/10.1016/j.bmcl.2011.02.101
https://doi.org/10.1016/j.bmcl.2011.02.101
Autor:
Frederick Lee, Erik Vogan, Roseann Petersen, Mengxiao Shi, John W. Ellingboe, Jennifer M. Golas, Ariamala Gopalsamy, May S. Tam, Ramaswamy Nilakantan, Kim Arndt, Jaison Jacob, Kristin Svenson, Yingxia Wen, Mark S. Johnson, Rajiv Chopra, Frank Boschelli
Publikováno v:
Journal of medicinal chemistry. 51(3)
Heat shock protein 90 (Hsp90) is a molecular chaperone that is responsible for activating many signaling proteins and is a promising target in tumor biology. We have identified small-molecule benzisoxazole derivatives as Hsp90 inhibitors. Crystallogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711c4b8d4aa444b3259466eaa72ef664
https://pubmed.ncbi.nlm.nih.gov/18197612
https://pubmed.ncbi.nlm.nih.gov/18197612
Autor:
Thomas Walz, Randy Schekman, Erik Vogan, Benjamin M. Petre, Gerardo Z. Lederkremer, Yifan Cheng, Sebastian Springer, Tomas Kirchhausen
COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e9d23fb9096828f3868f417e32c194
https://europepmc.org/articles/PMC58530/
https://europepmc.org/articles/PMC58530/
Autor:
Erik Vogan
Publikováno v:
Structure. 13:493
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f869f9ce7e2464d4fb92fc518238d0d
https://doi.org/10.1016/j.str.2005.02.006
https://doi.org/10.1016/j.str.2005.02.006
Autor:
Ariamala Gopalsamy, Mengxiao Shi, Jennifer Golas, Erik Vogan, Jaison Jacob, Mark Johnson, Frederick Lee, Ramaswamy Nilakantan, Roseann Petersen, Kristin Svenson, Rajiv Chopra, May S. Tam, Yingxia Wen, John Ellingboe, Kim Arndt, Frank Boschelli
Publikováno v:
Journal of Medicinal Chemistry; Jan2008, Vol. 51 Issue 3, p373-375, 3p
Autor:
Erik Vogan
Publikováno v:
Structure. (8):902-903
The structure of shikimate 5-dehydrogenase, the fourth enzyme in the shikimate biosynthesis pathway and a member of a large enzyme family without clear structural peer, reveals a novel topological fold for the substrate binding domain and, through ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f9926ce10e6735f2ab66998c1eb701