Zobrazeno 1 - 10
of 479
pro vyhledávání: '"Erik V. Van der Eycken"'
Publikováno v:
Molecules, Vol 29, Iss 10, p 2176 (2024)
Camptothecin and its analogues show important antitumor activity and have been used in clinical studies. However, hydrolysis of lactone in the E ring seriously attenuates the antitumor activity. To change this situation, aromathecin alkaloids are inv
Externí odkaz:
https://doaj.org/article/3c8e4a1f304e4937acb33bae6d6b97bb
Publikováno v:
CHIMIA, Vol 77, Iss 5 (2023)
The popularity of microflow chemistry has skyrocketed in the last 20 years, more and more chemists are switching from macro-batch reactors to miniaturized flow devices. As a result, microfluidics is paving its way into the future by consolidating its
Externí odkaz:
https://doaj.org/article/ab2e956e780541158ce9a313a89339f6
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101162- (2022)
Summary: Here, we present a robust protocol for the facile and rapid synthesis of functionalized secondary amines in continuous flow. More specifically, we describe a detailed guide to perform a photocatalyzed Petasis reaction within 50 min using alk
Externí odkaz:
https://doaj.org/article/5b52cafafb03454f989a4170e5fd2b3f
Autor:
Lise Dieltjens, Kenny Appermans, Maries Lissens, Bram Lories, Wook Kim, Erik V. Van der Eycken, Kevin R. Foster, Hans P. Steenackers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Bacterial biofilms rely on shared extracellular polymeric substances (EPS) and are often highly tolerant to antibiotics. Here, the authors show in in vitro experiments that Salmonella does not evolve resistance to EPS inhibition because such strains
Externí odkaz:
https://doaj.org/article/0fe92426ee98474f992afb748d21b64e
Autor:
Monica Oliva, Prabhat Ranjan, Serena Pillitteri, Guglielmo Attilio Coppola, Monica Messina, Erik V. Van der Eycken, Upendra Kumar Sharma
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103134- (2021)
Summary: Multicomponent reactions (MCRs) are ideal platforms for the generation of a wide variety of organic scaffolds in a convergent and atom-economical manner. Many strategies for the generation of highly substituted and diverse structures have be
Externí odkaz:
https://doaj.org/article/45fe4447ba2a4bf79afe60fd74fc6b38
Autor:
Gerardo M. Ojeda, Prabhat Ranjan, Pavel Fedoseev, Lisandra Amable, Upendra K. Sharma, Daniel G. Rivera, Erik V. Van der Eycken
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2447-2457 (2019)
An efficient sequence based on the Ugi-azide reaction and rhodium(III)-catalyzed intermolecular annulation has been established for the preparation of tetrazole-isoquinolone/pyridone hybrids. Several N-acylaminomethyltetrazoles were reacted with aryl
Externí odkaz:
https://doaj.org/article/9a41587abdf84df8b78b9684defcd164
Autor:
Maryna V. Murlykina, Oleksandr V. Kolomiets, Maryna M. Kornet, Yana I. Sakhno, Sergey M. Desenko, Victoriya V. Dyakonenko, Svetlana V. Shishkina, Oleksandr A. Brazhko, Vladimir I. Musatov, Alexander V. Tsygankov, Erik V. Van der Eycken, Valentyn A. Chebanov
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 1281-1288 (2019)
Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combina
Externí odkaz:
https://doaj.org/article/3a24c20c8f48455694968620fa65fe59
Autor:
Victoria V. Lipson, Tetiana L. Pavlovska, Nataliya V. Svetlichnaya, Anna A. Poryvai, Nikolay Yu. Gorobets, Erik V. Van der Eycken, Irina S. Konovalova, Svetlana V. Shiskina, Alexander V. Borisov, Vladimir I. Musatov, Alexander V. Mazepa
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 1032-1045 (2019)
The unexpectedly uncatalyzed reaction between 2-amino-4-arylimidazoles, aromatic aldehydes and Meldrum’s acid has selectively led to the corresponding Knoevenagel–Michael adducts containing a free amino group in the imidazole fragment. The adduct
Externí odkaz:
https://doaj.org/article/f9c01293fdbb4489a089a044f45cc79a
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 571-576 (2019)
A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp2)–H activation and C(sp3)–H amination has been developed. This approach shows excellent f
Externí odkaz:
https://doaj.org/article/f1e68b57e03b413484ba20382d2d38c9
Autor:
Guglielmo Attilio Coppola, Jolien Onsea, T. Fintan Moriarty, Dirk Nehrbass, Caroline Constant, Stephan Zeiter, Merve Kübra Aktan, Annabel Braem, Erik V. Van der Eycken, Hans P. Steenackers, Willem-Jan Metsemakers
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Orthopedic device-related infections remain a serious challenge to treat. Central to these infections are bacterial biofilms that form on the orthopedic implant itself. These biofilms shield the bacteria from the host immune system and most common an
Externí odkaz:
https://doaj.org/article/8aa6027ffe4d4d67a3374a8cfca338e8