Výsledky vyhledávání - "Erik S Vermeulen"

Alternative methods for labeling the 5-HT1A receptor agonist, 1-[2-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphthyl)piperazine (S14506), with carbon-11 or fluorine-18

Autor: Shuiyu Lu, Erik S Vermeulen, Håkan Wikström, Victor W. Pike, Jinsoo Hong, Frederick T. Chin, John L. Musachio

Publikováno v: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 48(13), 971-981. Wiley

1-[2-(4-Fluorobenzoylamino)ethyl]-4-(7-methoxynaphthyl)piperazine (S14506) is one of the most potent and selective agonists at 5-HT1A receptors. For the purpose of prospective 5-HT1A receptor imaging with positron emission tomography and the investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7935814b1a907a8c97130570f52842
https://doi.org/10.1002/jlcr.1009

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Characterization of the 5-HT7 receptor. Determination of the pharmacophore for 5-HT7 receptor agonism and CoMFA-based modeling of the agonist binding site

Autor: Erik S Vermeulen, Anne W Schmidt, Jeffrey S Sprouse, Håkan Wikström, Cor J. Grol

Publikováno v: Journal of Medicinal Chemistry, 46(25), 5365-5374. AMER CHEMICAL SOC

On the basis of a set of 20 diverse 5-HT7 receptor agonists, the pharmacophore for 5-HT7 receptor agonism was determined. Additionally two CoMFA models were developed, based on different alignments of the agonists. Both models show good correlations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7df6cdb0ed8d51c6f81797ed644a42
https://doi.org/10.1021/jm030826m

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Novel 5-HT7 receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides

Autor: Cor J. Grol, Marjan van Smeden, Anne W Schmidt, Håkan Wikström, Erik S Vermeulen, Jeffrey S Sprouse

Publikováno v: Journal of Medicinal Chemistry, 47(22), 5451-5466. AMER CHEMICAL SOC

A series of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides was synthesized and evaluated for their interactions with the constitutively active 5-HT7 receptor. Effects on basal adenylate cyclase activity were measured using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088603e4b6f2d325facd4f1efb3520cf
https://research.rug.nl/en/publications/52e60827-0c93-48b0-87c6-ea76b0b8054e

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Further characterization of structural requirements for ligands at the dopamine D(2) and D(3) receptor: exploring the thiophene moiety

Autor: Nienke Rodenhuis, Thomas A. Pugsley, LD Wise, Hakan Wikstrom, Durk Dijkstra, Erik S Vermeulen

Publikováno v: Journal of Medicinal Chemistry, 45(14), 3022-3031. AMER CHEMICAL SOC

The present study describes the synthesis and in vitro pharmacology of a novel series of dopaminergic agents in which the classical phenylethylamine pharmacophore is replaced by a thienylethylamine moiety. In general, the novel compounds showed a mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482b1a97cbf4ecbc5206d0a095acdd23
https://pubmed.ncbi.nlm.nih.gov/12086487

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Ion-pair formation of hydroquinine by chromatography

Autor: S. Sundell, S Marchais, Graeme Semple, Hakan Wikstrom, Erik S Vermeulen

Publikováno v: Analytica Chimica Acta, 426(1), 85-93. ELSEVIER SCIENCE BV

The study of hydroquinine, a Cinchona alkaloid, by analytical TLC (silica gel) in a mixture of dichloromethane and methanol (9/1, v/v) has shown that a new compound, with a higher R-F value, is formed during the migration. Its structure has been eluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51e454272aec0d395ff89e68df2bd1f
https://research.rug.nl/en/publications/f3402d85-f20c-4537-80b7-9cd814f28492

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