Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Erik S Musiek"'
Autor:
Peng Li, Richa Saxena, Lei Gao, Hao Deng, Oluwaseun Akeju, Ariel Mueller, Kun Hu, Zhongcong Xie, Elizabeth Sugg, Elizabeth Gleeson, Sarah N Baker, Chenlu Gao, Shiqian Shen, Esteban Franco-Garcia, Erik S Musiek
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction Surgical patients over 70 experience postoperative delirium (POD) complications in up to 50% of procedures. Sleep/circadian disruption has emerged as a potential risk factor for POD in epidemiological studies. This protocol presents a si
Externí odkaz:
https://doaj.org/article/61844bc1ccb3433d8d9744c0b121cac3
Autor:
Erik S Musiek
Publikováno v:
The Lancet. Healthy Longevity, Vol 1, Iss 3, Pp e90-e91 (2020)
Externí odkaz:
https://doaj.org/article/42a76643b1e84e6ab191f0486278e5b9
Autor:
Percy Griffin, Patrick W Sheehan, Julie M Dimitry, Chun Guo, Michael F Kanan, Jiyeon Lee, Jinsong Zhang, Erik S Musiek
Publikováno v:
eLife, Vol 9 (2020)
The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and
Externí odkaz:
https://doaj.org/article/0ab574e86a24483f961650ad5eafeaa9
Publikováno v:
Journal of Experimental Neuroscience, Vol 13 (2019)
Recently, we described a role for the circadian clock protein and nuclear receptor Rev-erbα in regulating glial activation states in the brain. Deletion of Rev-erbα resulted in microglial as well as astrocytic activation, while a Rev-erbα agonist
Externí odkaz:
https://doaj.org/article/a9f53dc35f174555b9c6652e9a945781
Autor:
Deborah A Roby, Fernanda Ruiz, Bailey A Kermath, Jaymie R Voorhees, Michael Niehoff, Jinsong Zhang, John E Morley, Erik S Musiek, Susan A Farr, Thomas P Burris
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215004 (2019)
Alzheimer's disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease. Loss of function of the nuclear receptor REV-ERB is associated with reduced cogniti
Externí odkaz:
https://doaj.org/article/7ba6c1052d43431a943bc8a7c18487ba
Publikováno v:
Annals of Neurology. 93:877-880
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3adf2dbad4a0e1fe62a7aa6cbbb5876b
https://doi.org/10.1002/ana.26643
https://doi.org/10.1002/ana.26643
Publikováno v:
Proceedings of the National Academy of Sciences. 120
An emerging role for the circadian clock in autophagy and lysosome function has opened new avenues for exploration in the field of neurodegeneration. The daily rhythms of circadian clock proteins may coordinate gene expression programs involved not o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1457acdd386ced47ba9799d0ed638438
https://doi.org/10.1073/pnas.2220551120
https://doi.org/10.1073/pnas.2220551120
Autor:
Margaret Moline, Carsten T. Beuckmann, Masahiro Bando, Erik S. Musiek, Toshitaka Sato, Takashi Ueno, Hiroyuki Suzuki, Yoshihide Osada
Publikováno v:
Journal of Alzheimer's Disease
Background: Many patients with Alzheimer’s disease (AD) display circadian rhythm and sleep-wake disturbances. However, few mouse AD models exhibit these disturbances. Lemborexant, a dual orexin receptor antagonist, is under development for treating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004d3112956659618a61bc14dc42efc5
https://doi.org/10.3233/jad-201054
https://doi.org/10.3233/jad-201054
Autor:
S Kendall Smith, Peter Tran, Katherine A Madden, Jill Boyd, Rosemary Braun, Erik S Musiek, Yo-El S Ju
Publikováno v:
Sleep. 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b2c0a8acd64f971a191d397b27f3e9
https://doi.org/10.1093/sleep/zsac148
https://doi.org/10.1093/sleep/zsac148
Autor:
Steve Salloway, Anne M. Fagan, Neill R. Graff-Radford, Robert A. Koeppe, Ani Eloyan, Lea T. Grinberg, Bradford C. Dickerson, Constantine Gatsonis, Walter A. Kukull, Thomas S. Wingo, Amy Trullinger, Gregory S. Day, Emily Rogalski, David A. Wolk, Paul S. Aisen, Prashanthi Vemuri, Joel H. Kramer, Gil D. Rabinovici, Erik S. Musiek, Tatiana Foroud, Arthur W. Toga, Clifford R. Jack, Mario F. Mendez, Leonardo Iaccarino, Joseph C. Masdeu, Malia Rumbaugh, Keith N. Fargo, Liana G. Apostolova, Chiadi U. Onyike, Kelly N.H. Nudelman, Lawrence S. Honig, Maria C. Carrillo, Melissa E. Murray, David T.W. Jones
Publikováno v:
Alzheimer's & Dementia. 17:2043-2055
Patients with early-onset Alzheimer's disease (EOAD) are commonly excluded from large-scale observational and therapeutic studies due to their young age, atypical presentation, or absence of pathogenic mutations. The goals of the Longitudinal EOAD St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262d1d1a13f1175264b7bde0737a2158
https://doi.org/10.1002/alz.12350
https://doi.org/10.1002/alz.12350