Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Erik S Knudsen"'
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8558 (2010)
The RB and p53 tumor suppressors are mediators of DNA damage response, and compound inactivation of RB and p53 is a common occurrence in human cancers. Surprisingly, their cooperation in DNA damage signaling in relation to tumorigenesis and therapeut
Externí odkaz:
https://doaj.org/article/e9c4d51e3283444796014b846c6b9dce
Autor:
Agnieszka K. Witkiewicz, Emily Schultz, Jianxin Wang, Deanna Hamilton, Ellis Levine, Tracey O’Connor, Erik S. Knudsen
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-17 (2023)
Abstract Despite widespread use and a known mechanism of action for CDK4/6 inhibitors in combination with endocrine therapy, features of disease evolution and determinants of therapeutic response in the real-world setting remain unclear. Here, a coho
Externí odkaz:
https://doaj.org/article/5de605e33d5e4dbfb69355f793daa911
Autor:
Ryan M. Finnegan, Ahmed M. Elshazly, Nipa H. Patel, Liliya Tyutyunyk-Massey, Tammy H. Tran, Vishnu Kumarasamy, Erik S. Knudsen, David A. Gewirtz
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Anti-estrogens or aromatase inhibitors in combination with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are the current standard of care for estrogen receptor-positive (ER+) Her-2 negative metastatic breast cancer. Although these combination t
Externí odkaz:
https://doaj.org/article/894a189ccef24ff08e4d0a659547be7f
Publikováno v:
Cancer Research. 83:P3-10
BACKGROUND: Deregulation of cellular proliferation represents a defining hallmark of cancer. The mechanisms driving aberrant cell cycle progression across different breast cancer subtypes is highly diverse and likely contributes to therapeutic resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f529289326afa8592ae31b96c69ef6ce
https://doi.org/10.1158/1538-7445.sabcs22-p3-10-01
https://doi.org/10.1158/1538-7445.sabcs22-p3-10-01
Autor:
Carsten Denkert, Miguel Martín, Michael Untch, Hervé R. Bonnefoi, Erik S. Knudsen, Seock-Ah Im, Angela DeMichele, Agnieszka Witkiewicz, Laura Van ’t Veer, Sung-Bae Kim, Harry D. Bear, Nicole McCarthy, Karen Gelmon, Frederik Marmé, José Ángel García-Sáenz, Nicholas Turner, Federico Rojo, Martin Filipits, Lesley-Ann Martin, Peter A. Fasching, Christian Schem, Catherine M. Kelly, Toralf Reimer, Masakazu Toi, Hope Rugo, Michael Gnant, Andreas Makris, Yuan Liu, Karsten Weber, Sivaramakrishna Rachakonda, Sibylle Loibl
Publikováno v:
Cancer Research. 83:HER2-06
Background: Breast cancer with low HER2 expression (HER2-low) is of high clinical relevance because of new therapeutic options with antibody-drug conjugates. We have recently shown in a large cohort from neoadjuvant clinical trials that HER2-low brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::093af37d9a91299aaf82f447fa65e26f
https://doi.org/10.1158/1538-7445.sabcs22-her2-06
https://doi.org/10.1158/1538-7445.sabcs22-her2-06
Publikováno v:
Trends Cancer
The mammalian cell cycle has been extensively studied regarding cancer etiology, progression, and therapeutic intervention. The canonical cell cycle framework is supported by a plethora of data pointing to a relatively simple linear pathway in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0acd4f5d101a00faf0becf3d8d8082
https://doi.org/10.1016/j.trecan.2022.04.006
https://doi.org/10.1016/j.trecan.2022.04.006
Autor:
Vishnu Kumarasamy, Costakis Frangou, Jianxin Wang, Yin Wan, Andrew Dynka, Hanna Rosenheck, Prasenjit Dey, Ethan V. Abel, Erik S. Knudsen, Agnieszka K. Witkiewicz
Publikováno v:
bioRxiv
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease for which new therapeutic interventions are needed. Here we assessed the cellular response to pharmacological KRAS inhibition, which target the central oncogenic factor in PDAC. In a pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36714798a32bbef211c9956e58af68e
https://europepmc.org/articles/PMC10168422/
https://europepmc.org/articles/PMC10168422/
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3e88720028d1c1acd19d4e081944a9
https://doi.org/10.1158/2159-8290.c.6549708.v1
https://doi.org/10.1158/2159-8290.c.6549708.v1
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Supplementary Data from Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b4da81cbb00416f796f44e9fdd2b9
https://doi.org/10.1158/2159-8290.22541622.v1
https://doi.org/10.1158/2159-8290.22541622.v1
Autor:
Marc S. Ernstoff, Elizabeth A. Repasky, Hemn Mohammadpour, Igor Puzanov, Mark J. Bucsek, Joseph J. Drabick, Pauline Funchain, Suzanne Stack, Maria Levis, Carlos D. Cedeno, Paul K. Wallace, Joseph D. Tario, Cheryl Allen, Erik S. Knudsen, Agnieszka K. Witkiewicz, Wenyan Ji, Kristopher Attwood, Manu R. Pandey, Shipra Gandhi
Multispectral analysis of T-cell activation and exhaustion markers using antibodies for CD8, OX40, CTLA4, PD1, LAG3 and TIM3. A, Representative multiplex and monoplex images for a patient on the study using pre-treatment biopsy. B, Phenotyping was pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7cdb2e4243884866c51940aa4483d99
https://doi.org/10.1158/1078-0432.22479671.v1
https://doi.org/10.1158/1078-0432.22479671.v1