Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Erik R Sampson"'
Autor:
Rajeev K. Tyagi, Justin Jacobse, Jing Li, Margret M. Allaman, Kevin L. Otipoby, Erik R. Sampson, Keith T. Wilson, Jeremy A. Goettel
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Regulatory T (Treg) cells are essential to maintain immune homeostasis in the intestine and Treg cell dysfunction is associated with several inflammatory and autoimmune disorders including inflammatory bowel disease (IBD). Efforts using low-dose (LD)
Externí odkaz:
https://doaj.org/article/9fde11171f8341ed846e55a297e925bf
Autor:
Yueh-Chiang Hu, Shuyuan Yeh, Shauh-Der Yeh, Erik R. Sampson, Jiaoti Huang, Peng Li, Cheng-Lung Hsu, Huei-Ju Ting, Hui-Kuan Lin, Liang Wang, Eungseok Kim, Jing Ni, Chawnshang Chang
Publikováno v:
J Biol Chem
Androgen receptor (AR)-associated coregulator 70 (ARA70) was the first identified AR coregulator. However, its molecular mechanism and biological relevance to prostate cancer remain unclear. Here we show that ARA70 interacts with and promotes AR acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe902357be5bc8a140215b93d4b0918
https://pubmed.ncbi.nlm.nih.gov/15166229
https://pubmed.ncbi.nlm.nih.gov/15166229
Autor:
Jyothsna Visweswaraiah, Erik R Sampson, Timothy Kiprono, Parika Petaipimol, Adrianne Monsef, Katalin Kis-Toth, Kevin L Otipoby, John Sundy, Nathan Higginson-Scott, Joanne L Viney
Publikováno v:
The Journal of Immunology. 206:66.14-66.14
Regulatory T cells (Treg) are vital for immune homeostasis and are dysfunctional in autoimmunity. Interleukin 2 (IL-2) drives the proliferation and function of Tregs via its heterotrimeric receptor (CD25/CD122/CD132). Low dose IL-2 is being evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65768ddf9e253248a7bec80943d34b0c
https://doi.org/10.4049/jimmunol.206.supp.66.14
https://doi.org/10.4049/jimmunol.206.supp.66.14
Autor:
Dan Shi, Richard McCarthy, Erik R. Sampson, Neil Wishart, Igor Mikaelian, Lori Duggan, Annette Schwartz, Michael Hoemann, Marc Barnard, Andrew J. Long, Douglas Fritz, Christopher M. Harris, Christopher Stedman, Elizabeth M. O'Connor, David Honor, Robert Caldwell, Donna Conlon
Publikováno v:
Toxicologic pathology. 44(7)
Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase that is an important signaling enzyme downstream of immunoreceptors containing an intracellular immunoreceptor tyrosine activating motif (ITAM). These receptors encompass a wide variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e205f37ddb29264c1b5f7b1e155d9086
https://pubmed.ncbi.nlm.nih.gov/27324990
https://pubmed.ncbi.nlm.nih.gov/27324990
Autor:
Hartmut Land, Peter Salzman, Helene R. McMurray, Craig T. Jordan, Laurel Newman, Erik R. Sampson, Duane C. Hassane
Publikováno v:
Oncogene. 32:3809-3818
Malignant cell transformation commonly results in the deregulation of thousands of cellular genes, an observation that suggests a complex biological process and an inherently challenging scenario for the development of effective cancer interventions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4b727f74056fcd39f1e21bbd5145b8
https://doi.org/10.1038/onc.2012.389
https://doi.org/10.1038/onc.2012.389
Autor:
Erik R. Sampson, Randy N. Rosier, Meina Wang, Resika Ubayawardena, Jonathan D. Holz, Tzong-Jen Sheu, Michael J. Zuscik, J. Edward Puzas, Eric E. Beier
Publikováno v:
Journal of Orthopaedic Research. 30:1760-1766
Lead remains a significant environmental toxin, and we believe we may have identified a novel target of lead toxicity in articular chondrocytes. These cells are responsible for the maintenance of joint matrix, and do so under the regulation of TGF-β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac29950dea9399aaa8a61d9839e51a74
https://doi.org/10.1002/jor.22117
https://doi.org/10.1002/jor.22117
Autor:
Robinder S. Dhillon, Chao Xie, Dan Li, Wakenda K. Tyler, Edward M. Schwarz, Erik R. Sampson, Regis J. O'Keefe
Publikováno v:
Journal of Orthopaedic Research. 30:325-333
Management of various tumor metastases to bone has dramatically improved, but this is not so for renal cell carcinoma (RCC), which is a difficult surgical problem due to its great vascularity. Furthermore, the unique mechanisms that mediate RCC vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cca53becb69ea270c8adf72a19f2d792
https://doi.org/10.1002/jor.21500
https://doi.org/10.1002/jor.21500
Autor:
Brad A Martin, Edward M. Schwarz, Randy N. Rosier, Chao Xie, Regis J. O'Keefe, Erik R. Sampson, Aimee E Morris
Publikováno v:
Journal of Bone and Mineral Research. 26:1283-1294
Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. Ninety percent of patients who present with metastatic and 30% to 40% of patients with nonmetastatic disease experience relapse, creating an urgent need for novel th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc544a725ecc6708c7f57b54a416dbfd
https://doi.org/10.1002/jbmr.336
https://doi.org/10.1002/jbmr.336
Autor:
Hani A. Awad, Randy N. Rosier, Edward M. Schwarz, Michael J. Zuscik, Krista L. Canary, Matthew J. Hilton, Erik R. Sampson, Regis J. O'Keefe, Christopher A. Beck, Di Chen, John P. Ketz
Publikováno v:
Journal of Orthopaedic Research. 29:1145-1151
The goals of our study were to establish quantitative outcomes for assessing murine knee arthritis and develop an Arthritis Index that incorporates multiple outcomes into a single calculation that provides enhanced sensitivity. Using an accepted mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05a0a68576a937e3bb3601d1462589ec
https://doi.org/10.1002/jor.21368
https://doi.org/10.1002/jor.21368
Autor:
Erik R. Sampson, Lin Gao, Tian-Fang Li, Edward M. Schwarz, Jennifer H. Jonason, Regis J. O'Keefe, Michael J. Zuscik, Tzong-Jen Sheu, Di Chen, Yrjö T. Konttinen, Lisa M. Flick
Publikováno v:
Arthritis & Rheumatism. 62:2359-2369
Objective To investigate the biologic significance of Smad3 in the progression of osteoarthritis (OA), the crosstalk between Smad3 and activating transcription factor 2 (ATF-2) in the transforming growth factor β (TGFβ) signaling pathway, and the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c6589bbdfcbed46804c817a6f282422
https://doi.org/10.1002/art.27537
https://doi.org/10.1002/art.27537