Intravenous and oral whole body ketone dosimetry, biodistribution, metabolite correction and kinetics studied by (R)-[1-11C]β-hydroxybutyrate ([11C]OHB) PET in healthy humans

Autor: Thien Vinh Luong, Erik Nguyen Nielsen, Lise Falborg, Mette Louise Gram Kjærulff, Lars Poulsen Tolbod, Esben Søndergaard, Niels Møller, Ole Lajord Munk, Lars Christian Gormsen

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-16 (2023)

Abstract Background Ketones are increasingly recognized as an important and possibly oxygen sparing source of energy in vital organs such as the heart, the brain and the kidneys. Drug treatments, dietary regimens and oral ketone drinks designed to de

Externí odkaz: https://doaj.org/article/04a444ae3ac344f09e03bddcc5e9af0f

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First-in-human whole-body PET/CT imaging with the optimized ketone tracer [¹¹C]β-hydroxybutyrate using a long axial field-of-view scanner.

Autor: Kjaerulff, Mette Louise Gram, Nielsen, Erik Nguyen, Gormsen, Lars Christian, Dias, André Henrique

Publikováno v: European Journal of Nuclear Medicine & Molecular Imaging; Oct2024, Vol. 51 Issue 12, p3802-3804, 3p

Intravenous and oral whole body ketone dosimetry, biodistribution, metabolite correction and kinetics studied by (R)-[1- ¹¹ C]β-hydroxybutyrate ([ ¹¹ C]OHB) PET in healthy humans.

Autor: Luong TV; Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus N, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, 8200, Aarhus N, Denmark., Nielsen EN; Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus N, Denmark., Falborg L; Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus N, Denmark., Kjærulff MLG; Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus N, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, 8200, Aarhus N, Denmark., Tolbod LP; Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Søndergaard E; Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, 8200, Aarhus N, Denmark., Møller N; Medical/Steno Aarhus Research Laboratory, Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, 8200, Aarhus N, Denmark.; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 161, 8200, Aarhus N, Denmark., Munk OL; Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Gormsen LC; Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus N, Denmark. lars.christian.gormsen@clin.au.dk.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. lars.christian.gormsen@clin.au.dk.

Publikováno v: EJNMMI radiopharmacy and chemistry [EJNMMI Radiopharm Chem] 2023 Jun 14; Vol. 8 (1), pp. 12. Date of Electronic Publication: 2023 Jun 14.