Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Erik M. Lenarcic"'
Autor:
You Li, Ichiro Misumi, Tomoyuki Shiota, Lu Sun, Erik M. Lenarcic, Hyejeong Kim, Takayoshi Shirasaki, Adriana Hertel-Wulff, Taylor Tibbs, Joseph E. Mitchell, Kevin L. McKnight, Craig E. Cameron, Nathaniel J. Moorman, David R. McGivern, John M. Cullen, Jason K. Whitmire, Stanley M. Lemon
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(28)
Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands of hospitalizations and hundreds of deaths within the United States in recent years. There is no effective antiviral therapy for hepatitis A, and many aspects of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e039933171d7368ec93e9b859043a18
https://pubmed.ncbi.nlm.nih.gov/35867748
https://pubmed.ncbi.nlm.nih.gov/35867748
Autor:
Andrew E. Hale, Nathaniel J. Moorman, Suzu Igarashi, Erik M. Lenarcic, Jeremy P. Kamil, Felicia Goodrum, Donna Collins-McMillen
Publikováno v:
Proc Natl Acad Sci U S A
Human progenitor cells (HPCs) support human cytomegalovirus (HCMV) latency, and their differentiation along the myeloid lineage triggers cellular cues that drive reactivation. A key step during HCMV reactivation in latently infected HPCs is reexpress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d87c4b665009cc2054106116609ba91
https://doi.org/10.1073/pnas.2002651117
https://doi.org/10.1073/pnas.2002651117
Autor:
Xuan Yang, Rebekah J. Dickmander, Armin Bayati, Sharon A. Taft-Benz, Jeffery L. Smith, Carrow I. Wells, Emily A. Madden, Jason W. Brown, Erik M. Lenarcic, Boyd L. Yount, Edcon Chang, Alison D. Axtman, Ralph S. Baric, Mark T. Heise, Peter S. McPherson, Nathaniel J. Moorman, Timothy M. Willson
Publikováno v:
bioRxiv : the preprint server for biology.
Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human and murine β-coronaviruses. The potency of in-cell CSNK2A target engagement across the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bd622de1b2d4f231e2e25fae832788
https://pubmed.ncbi.nlm.nih.gov/35723434
https://pubmed.ncbi.nlm.nih.gov/35723434
Autor:
Xuan Yang, Rebekah J. Dickmander, Armin Bayati, Sharon A. Taft-Benz, Jeffery L. Smith, Carrow I. Wells, Emily A. Madden, Jason W. Brown, Erik M. Lenarcic, Boyd L. Yount, Edcon Chang, Alison D. Axtman, Ralph S. Baric, Mark T. Heise, Peter S. McPherson, Nathaniel J. Moorman, Timothy M. Willson
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 3
article-version (status) pre
article-version (number) 3
Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human and murine β-coronaviruses. The potency of in-cell CSNK2A target engagement across the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc35b8d18d3437b057697dea428a8e3
Publikováno v:
Virology
Human cytomegalovirus (HCMV) manipulates multiple cellular processes to facilitate virus replication, including the control of mRNA translation. We previously showed that the HCMV TRS1 protein (pTRS1) promotes cap-dependent mRNA translation independe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09376ae631693ed514e153f1176fa056
https://doi.org/10.1016/j.virol.2019.08.026
https://doi.org/10.1016/j.virol.2019.08.026
Autor:
Bing Wu, Jian Jin, Ciprian P. Gheorghe, Karina D. Torralba, Li Wang, Xian Chen, Adil Muneer, Hongjun Song, Emerald Hillary Feng, Erik M. Lenarcic, Feng Zhang, Nathaniel J. Moorman, Yisong Y. Wan, Juan Song, Liu Mei, Yan Xiong, Ling Xie, Jeanette Gowen Cook, Xufen Yu, Charles Wang
Publikováno v:
bioRxiv
Hyperinflammation and lymphopenia provoked by SARS-CoV-2-activated macrophages contribute to the high mortality of Coronavirus Disease 2019 (COVID-19) patients. Thus, defining host pathways aberrantly activated in patient macrophages is critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1032cd2f6ccd958b293d8e1050115394
https://doi.org/10.1101/2020.11.14.382416
https://doi.org/10.1101/2020.11.14.382416
Autor:
Donna Collins-McMillen, Felicia Goodrum, Nathaniel J. Moorman, Erik M. Lenarcic, Jeremy P. Kamil, Andrew E. Hale
A key step during viral reactivation from latency is the re-expression of viral genes. Hematopoietic progenitor cells (HPCs) support human cytomegalovirus (HCMV) latency, and their differentiation triggers cellular cues that drive reactivation. A key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbb29493594603da7332ac58dd130eb
https://doi.org/10.1101/2020.02.10.942433
https://doi.org/10.1101/2020.02.10.942433
Autor:
Nathaniel J. Moorman, Hui Feng, Olga González-López, Stanley M. Lemon, Jenny P.-Y. Ting, Jinyao Mo, Jason K. Whitmire, Daisuke Yamane, Lola M. Reid, Ichiro Misumi, Joseph A. Duncan, Erik M. Lenarcic, Haitao Guo, Eliane Wauthier, David R. McGivern
Publikováno v:
Nature Immunology. 18:1299-1309
NLRX1 is unique among the nucleotide-binding-domain and leucine-rich-repeat (NLR) proteins in its mitochondrial localization and ability to negatively regulate antiviral innate immunity dependent on the adaptors MAVS and STING. However, some studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f3305a1acf56e01b3b0501777ff6cc0
https://doi.org/10.1038/ni.3853
https://doi.org/10.1038/ni.3853
Autor:
Wes Sanders, Ralph S. Baric, Heather A. Vincent, Angela Wahl, Nathaniel J. Moorman, J. Victor Garcia, Erik M. Lenarcic, Allison Boone, Miriam Braunstein, Christian R. Aguilera-Sandoval, Yinyan Xu, Nilu Goonetilleke, Paul A. Dayton, William H. Hildebrand, Maria Abad Fernandez, Chandrav De, Adam S. Cockrell, Claire Johnson, Raymond J. Pickles, Nathaniel J. Schramm, Laura Rank, Isabel G. Newsome, Rachel A. Cleary
Publikováno v:
Nature Biotechnology
Nature biotechnology
Nature biotechnology
A major limitation of current humanized mouse models is that they primarily enable the analysis of human-specific pathogens that infect hematopoietic cells. However, most human pathogens target other cell types, including epithelial, endothelial and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc55f8e20e208959483e150be43a478b
https://doi.org/10.1038/s41592-020-0777-0
https://doi.org/10.1038/s41592-020-0777-0
Publikováno v:
Journal of Virology. 92
The human cytomegalovirus (HCMV) immediate early 1 (IE1) and IE2 proteins are critical regulators of virus replication. Both proteins are needed to efficiently establish lytic infection, and nascent expression of IE1 and IE2 is critical for reactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0d03d2045f669e9577ae8c5336698b
https://doi.org/10.1128/jvi.02128-17
https://doi.org/10.1128/jvi.02128-17