Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Erik M. Boczko"'
Publikováno v:
Journal of Biological Dynamics
We consider a dynamical model of cell cycles of n cells in a culture in which cells in one specific phase (S for signalling) of the cell cycle produce chemical agents that influence the growth/cell cycle progression of cells in another phase (R for r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a2031d7be7f524e3c65014e62e73ea
https://doi.org/10.1080/17513758.2014.904526
https://doi.org/10.1080/17513758.2014.904526
Publikováno v:
Mathematical Biosciences. 235:189-200
In order to gain a deeper understanding of the onset and progression of pulmonary infections we present and analyze a low dimensional, phenomenological model of infection and the innate immune response in the lungs. Because pulmonary innate immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4f7a4ec1549b8d32245956595145b8
https://doi.org/10.1016/j.mbs.2011.12.004
https://doi.org/10.1016/j.mbs.2011.12.004
Publikováno v:
Applied Biochemistry and Biotechnology. 156:59-75
Four decades of work have clearly established the existence of autonomous oscillations in budding yeast culture across a range of operational parameters and in a few strains. Autonomous oscillations impact substrate conversion to biomass and products
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e67d9e05ac14eb0cd89011f8167016
https://doi.org/10.1007/s12010-008-8486-7
https://doi.org/10.1007/s12010-008-8486-7
Publikováno v:
Journal of Mathematical Biology. 55:679-719
We consider the dynamics of a model toggle switch abstracted from the genetic interactions operative in a fungal stress response circuit. The switch transduces an external signal and propagates it forward by mediating the transport between compartmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ce4681b3c52f9e6f9de45f67470af4
https://doi.org/10.1007/s00285-007-0102-x
https://doi.org/10.1007/s00285-007-0102-x
Publikováno v:
Topology and its Applications. 154(13):2501-2520
The analysis of the qualitative behavior of flows generated by ordinary differential equations often requires quantitative information beyond numerical simulation which can be difficult to obtain analytically. In this paper we present a computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62767b84f10f1300c6746d1d163ee40
Autor:
Peter Hinow, Erik M. Boczko
Publikováno v:
Journal of Theoretical Biology. 246:145-158
The density profile of an elastic fiber like DNA will change in space and time as ligands associate with it. This observation affords a new direction in single molecule studies provided that density profiles can be measured in space and time. In fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0787b8f18d38107b9862f3df80dda57
https://doi.org/10.1016/j.jtbi.2006.11.013
https://doi.org/10.1016/j.jtbi.2006.11.013
Autor:
Chris C. Stowers, Erik M. Boczko
Publikováno v:
Yeast. 24:533-541
We report the results of an optical assay to determine the degree of cell wall disruption in yeast. The results indicate that cell wall disruption with glass beads yields reproducible results that can be modelled with an integral measure of time to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2974493947c7215c2ac06f1e88e1ef88
https://doi.org/10.1002/yea.1491
https://doi.org/10.1002/yea.1491
Publikováno v:
Molecular Genetics and Metabolism. 84:104-111
Understanding how DNA sequence variations impact human health through a hierarchy of biochemical and physiological systems is expected to improve the diagnosis, prevention, and treatment of common, complex human diseases. We have previously developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597687cb7f892929121abaae59810a14
https://doi.org/10.1016/j.ymgme.2004.10.006
https://doi.org/10.1016/j.ymgme.2004.10.006
Autor:
Todd Young, Erik M. Boczko
Publikováno v:
International Journal of Bifurcation and Chaos. 14:3557-3566
We study a finite uni-directional array of "cascading" or "threshold coupled" chaotic maps. Such systems have been proposed for use in nonlinear computing and have been applied to classification problems in bioinformatics. We describe some of the att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35da0b5c068ccfa879e6eb19f89fe533
https://doi.org/10.1142/s0218127404011570
https://doi.org/10.1142/s0218127404011570
Autor:
Stephen T. Ingalls, Stanton Gerson, Timothy P. Spiro, Charles L. Hoppel, Xiaolin Li, Susan M. Majka, Kou Yi Tserng, James K. V. Willson, Erik M. Boczko
Publikováno v:
The Journal of Clinical Pharmacology. 43:881-893
O 6 -Benzylguanine and its metabolite, 8-oxo-O 6 -benzylguanine, are equally potent inhibitors of the DNA repair enzyme, O 6 -alkylguanine-DNA alkyltransferase. Pharmacokinetic values are derived from cancer patients participating in a phase I trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da83282dc27392377556dc37c67fcf2
https://doi.org/10.1177/0091270003256060
https://doi.org/10.1177/0091270003256060