Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Erik M, Ullian"'
Autor:
Elise Marsan, Dmitry Velmeshev, Arren Ramsey, Ravi K. Patel, Jiasheng Zhang, Mark Koontz, Madeline G. Andrews, Martina de Majo, Cristina Mora, Jessica Blumenfeld, Alissa N. Li, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Erik M. Ullian, Matthew F. Krummel, Arnold R. Kriegstein, Eric J. Huang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Mutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar degeneration (FTLD). While previous studies implicate aberrant microglial activation as a disease-driving factor in neurodegeneration in the thalamocortical cir
Externí odkaz:
https://doaj.org/article/7f87fa9f28bd4ee9be391db5a7643359
Autor:
Stephen T. Magill, Harish N. Vasudevan, Kyounghee Seo, Javier E. Villanueva-Meyer, Abrar Choudhury, S. John Liu, Melike Pekmezci, Sarah Findakly, Stephanie Hilz, Sydney Lastella, Benjamin Demaree, Steve E. Braunstein, Nancy Ann Oberheim Bush, Manish K. Aghi, Philip V. Theodosopoulos, Penny K. Sneed, Adam R. Abate, Mitchel S. Berger, Michael W. McDermott, Daniel A. Lim, Erik M. Ullian, Joseph F. Costello, David R. Raleigh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperativel
Externí odkaz:
https://doaj.org/article/009c5504e81841cb823079d832c9273c
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma
Autor:
S. John Liu, Martina Malatesta, Brian V. Lien, Parna Saha, Shivani S. Thombare, Sung Jun Hong, Leslie Pedraza, Mark Koontz, Kyounghee Seo, Max A. Horlbeck, Daniel He, Harjus S. Birk, Miten Jain, Hugh E. Olsen, Mark Akeson, Jonathan S. Weissman, Michelle Monje, Nalin Gupta, David R. Raleigh, Erik M. Ullian, Daniel A. Lim
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-18 (2020)
Abstract Background Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy. However, the vast majority of lncRNAs have not been tested as potent
Externí odkaz:
https://doaj.org/article/158146c58ea3458da92657b2d5201345
Autor:
Robert Krencik, Kyounghee Seo, Jessy V. van Asperen, Nupur Basu, Caroline Cvetkovic, Saba Barlas, Robert Chen, Connor Ludwig, Chao Wang, Michael E. Ward, Li Gan, Philip J. Horner, David H. Rowitch, Erik M. Ullian
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1745-1753 (2017)
Summary: Human astrocytes network with neurons in dynamic ways that are still poorly defined. Our ability to model this relationship is hampered by the lack of relevant and convenient tools to recapitulate this complex interaction. To address this ba
Externí odkaz:
https://doaj.org/article/180ee37331634d95b43857d43ea3108f
Autor:
Aditi Deshpande, Smita Yadav, Dang Q. Dao, Zhi-Yong Wu, Kenton C. Hokanson, Michelle K. Cahill, Arun P. Wiita, Yuh-Nung Jan, Erik M. Ullian, Lauren A. Weiss
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2678-2687 (2017)
Summary: A deletion or duplication in the 16p11.2 region is associated with neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In addition to clinical characteristics, carriers of the 16p11.2 copy-number variant (CNV)
Externí odkaz:
https://doaj.org/article/e096888b2b5949228a4344e7e69c0802
Autor:
Emmy Li, Camila Benitez, Steven C. Boggess, Mark Koontz, Indigo V.L. Rose, Nina Draeger, Olivia M. Teter, Avi J. Samelson, Erik M. Ullian, Martin Kampmann
SummaryThe sheer complexity of the brain has complicated our ability to understand its cellular mechanisms in health and disease. Genome-wide association studies have uncovered genetic variants associated with specific neurological phenotypes and dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::056f05365389b33cf38a55e21dff7f01
https://doi.org/10.1101/2023.04.26.538498
https://doi.org/10.1101/2023.04.26.538498
Autor:
Nicole Y. Tsai, Fei Wang, Kenichi Toma, Chen Yin, Jun Takatoh, Emily L. Pai, Kongyan Wu, Angela C. Matcham, Luping Yin, Eric J. Dang, Denise K. Marciano, John L. Rubenstein, Fan Wang, Erik M. Ullian, Xin Duan
Publikováno v:
Nature neuroscience, vol 25, iss 5
Nat Neurosci
Nat Neurosci
The mouse visual system serves as an accessible model to understand mammalian circuit wiring. Despite rich knowledge in retinal circuits, the long-range connectivity map from distinct retinal ganglion cell (RGC) types to diverse brain neuron types re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70049f6330f88c9b1ad81c6b00060656
https://doi.org/10.1038/s41593-022-01068-8
https://doi.org/10.1038/s41593-022-01068-8
Autor:
Rebecca Josowitz, Sonia Mulero-Navarro, Nelson A. Rodriguez, Christine Falce, Ninette Cohen, Erik M. Ullian, Lauren A. Weiss, Katherine A. Rauen, Eric A. Sobie, Bruce D. Gelb
Publikováno v:
Stem Cell Reports, Vol 7, Iss 3, Pp 355-369 (2016)
Germline mutations in BRAF cause cardio-facio-cutaneous syndrome (CFCS), whereby 40% of patients develop hypertrophic cardiomyopathy (HCM). As the role of the RAS/MAPK pathway in HCM pathogenesis is unclear, we generated a human induced pluripotent s
Externí odkaz:
https://doaj.org/article/60a6b92eb46e4d198cecafafd07476cc
Autor:
Kun Leng, Indigo V. L. Rose, Hyosung Kim, Wenlong Xia, Wilber Romero-Fernandez, Brendan Rooney, Mark Koontz, Emmy Li, Yan Ao, Shinong Wang, Mitchell Krawczyk, Julia TCW, Alison Goate, Ye Zhang, Erik M. Ullian, Michael V. Sofroniew, Stephen P. J. Fancy, Matthew S. Schrag, Ethan S. Lippmann, Martin Kampmann
Publikováno v:
Nature neuroscience, vol 25, iss 11
Nat Neurosci
Nat Neurosci
Astrocytes become reactive in response to insults to the central nervous system by adopting context-specific cellular signatures and outputs, but a systematic understanding of the underlying molecular mechanisms is lacking. In this study, we develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b04940260c4e04207c7276cc0710dfb
https://escholarship.org/uc/item/91n3m43s
https://escholarship.org/uc/item/91n3m43s
Autor:
Sydney Lastella, David R. Raleigh, Stephen T. Magill, Harish N. Vasudevan, Joseph F. Costello, Philip V. Theodosopoulos, Manish K. Aghi, Benjamin Demaree, Daniel A. Lim, Javier Villanueva-Meyer, Penny K. Sneed, Adam R. Abate, Steve Braunstein, Melike Pekmezci, Sarah Findakly, Michael W. McDermott, Kyounghee Seo, Abrar Choudhury, S. John Liu, Stephanie Hilz, Mitchel S. Berger, Erik M. Ullian, Nancy Ann Oberheim Bush
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Meningiomas are the most common primary intracranial tumors, but the molecular drivers of meningioma tumorigenesis are poorly understood. We hypothesized that investigating intratumor heterogeneity in meningiomas would elucidate biologic drivers and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0beb3ab8f0bf82e53e0fe6ce3b54034d
http://link.springer.com/article/10.1038/s41467-020-18582-7
http://link.springer.com/article/10.1038/s41467-020-18582-7