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Supplementary Fig. S3 from Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition

Autor: Albrecht Piiper, Rolf Marschalek, Bernd Kronenberger, Andreas Weigert, Tobias Schmid, Horst-Werner Korf, Stefan Zeuzem, Fabian Finkelmeier, Oliver Waidmann, Scarlett Nitsch, Otto Kollmar, Thomas Pleli, Bianca Kakoschky, Verena Köberle, Erik Kowarz, Christian Schmithals, Ahmed Atef Ibrahim

Supplementary Fig. S3. Doxycyline-induced overexpression of Dicer in HCC cells. HepG2 (A) and Huh-7 (B) cells stably transfected with the inducible Dicer construct were incubated with or without doxycycline (Dox) for 24 h. C: HepG2 cells with the ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153173b78795cd01540a4b2857d672af
https://doi.org/10.1158/1078-0432.22466477.v1

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Supplementary Table S1 from Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition

Table S1. Clinicopathological parameters of the patients with HCC. HBV, hepatitis B virus; HCV, hepatitis C virus

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https://doi.org/10.1158/1078-0432.22466471

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Data from Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition

Purpose: A role of Dicer, which converts precursor miRNAs to mature miRNAs, in the tumor-promoting effect of hypoxia is currently emerging in some tumor entities. Its role in hepatocellular carcinoma (HCC) is unknown.Experimental Design: HepG2 and Hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0051240aeb319e2ddd4c696dd0bad3
https://doi.org/10.1158/1078-0432.c.6526325

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Supplementary Fig. S2 from Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition

Supplementary Fig. S2. Tumor hypoxia increases EMT markers in HepG2 xenografts. Nude mice bearing HepG2 xenografts were sacrificed and the tumors were removed from the animals. Frozen sections of the tumors were stained with anti-E-cadherin (red) and

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https://doi.org/10.1158/1078-0432.22466480

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Supplementary Information from Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition

Supplementary Information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20816ba146821c93fd1d8d962e308247
https://doi.org/10.1158/1078-0432.22466474.v1

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Supplementary Fig. S1 from Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition

Supplementary Fig. S1. Apoptosis is not responsible for down-regulation of Dicer in HepG2 under hypoxic conditions. Western blot analysis of protein extracts from HepG2 cells cultured for 24 h under hypoxia (1% O2) (H) or normoxia (N) using anti-clea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddf6ee87c12007016303aa4b42f08c4
https://doi.org/10.1158/1078-0432.22466483.v1

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Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition

Autor: Andreas Weigert, Ahmed Atef Ibrahim, Rolf Marschalek, Oliver Waidmann, Otto Kollmar, Christian Schmithals, Scarlett Nitsch, Stefan Zeuzem, Verena Köberle, Albrecht Piiper, Tobias Schmid, Bianca Kakoschky, Horst-Werner Korf, Fabian Finkelmeier, Erik Kowarz, Bernd Kronenberger, Thomas Pleli

Publikováno v: Clinical Cancer Research. 23:3896-3905

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd813c807874b7d9dcc9cc1ce889cf3e
https://doi.org/10.1158/1078-0432.ccr-16-1762

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