Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Erik Kohlbrenner"'
Publikováno v:
Viruses, Vol 16, Iss 9, p 1366 (2024)
There was an update regarding the affiliation for Kyle Chamberlain [...]
Externí odkaz:
https://doaj.org/article/9cd4d78ae7094b8abb7267f9bbda1897
Publikováno v:
Viruses, Vol 16, Iss 3, p 442 (2024)
Today, adeno-associated virus (AAV)-based vectors are arguably the most promising in vivo gene delivery vehicles for durable therapeutic gene expression. Advances in molecular engineering, high-throughput screening platforms, and computational techni
Externí odkaz:
https://doaj.org/article/4dd1bf6e9fa44289b10cedc3d5d50b58
Autor:
Malik Bisserier, Michael G. Katz, Carlos Bueno-Beti, Agnieszka Brojakowska, Shihong Zhang, Sarah Gubara, Erik Kohlbrenner, Shahood Fazal, Anthony Fargnoli, Peter Dorfmuller, Marc Humbert, Akiko Hata, David A. Goukassian, Yassine Sassi, Lahouaria Hadri
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9105 (2021)
Pulmonary arterial hypertension (PAH) is a devastating lung disease characterized by the progressive obstruction of the distal pulmonary arteries (PA). Structural and functional alteration of pulmonary artery smooth muscle cells (PASMC) and endotheli
Externí odkaz:
https://doaj.org/article/c2eddd1d0a7e44b38138759eb42e499e
Autor:
Antanina Voit, Vishwendra Patel, Ronald Pachon, Vikas Shah, Mohammad Bakhutma, Erik Kohlbrenner, Joseph J. McArdle, Louis J. Dell’Italia, Jerry R. Mendell, Lai-Hua Xie, Roger J. Hajjar, Dongsheng Duan, Diego Fraidenraich, Gopal J. Babu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Sarcolipin is an inhibitor of the ATP dependent calcium pump SERCA, and is abnormally elevated in Duchenne muscular dystrophy. The authors show that reducing sarcolipin expression ameliorates skeletal muscle pathology and cardiomyopathy and extends l
Externí odkaz:
https://doaj.org/article/201501e20c1241caab7a1010c329171a
Autor:
Shin Watanabe, Kiyotake Ishikawa, Maria Plataki, Olympia Bikou, Erik Kohlbrenner, Jaume Aguero, Lahouaria Hadri, Iratxe Zarragoikoetxea, Kenneth Fish, Jane A. Leopold, Roger J. Hajjar
Publikováno v:
Pulmonary Circulation, Vol 8 (2018)
Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca 2+ -ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13). Nebulization of AAV1.SERCA2a re
Externí odkaz:
https://doaj.org/article/66d448932dd94386bd31bedc7c4bb649
Autor:
Jaydev Dave, Nour Raad, Nishka Mittal, Lu Zhang, Anthony Fargnoli, Jae Gyun Oh, Maria Elisabetta Savoia, Jens Hansen, Marika Fava, Xiaoke Yin, Konstantinos Theofilatos, Delaine Ceholski, Erik Kohlbrenner, Dongtak Jeong, Lauren Wills, Mathieu Nonnenmacher, Kobra Haghighi, Kevin D Costa, Irene C Turnbull, Manuel Mayr, Chen-Leng Cai, Evangelia G Kranias, Fadi G Akar, Roger J Hajjar, Francesca Stillitano
Publikováno v:
Cardiovasc Res
Aims A mutation in the phospholamban (PLN) gene, leading to deletion of Arg14 (R14del), has been associated with malignant arrhythmias and ventricular dilation. Identifying pre-symptomatic carriers with vulnerable myocardium is crucial because arrhyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbedb98cc0fa6633afea4ced1ed20e3
https://doi.org/10.1093/cvr/cvac021
https://doi.org/10.1093/cvr/cvac021
Autor:
Lu Zhang, Chen-Leng Cai, Zeki Ilkan, Dongtak Jeong, Philip Bittihn, Fadi G. Akar, Marine Cacheux, Nour Raad, Delaine K. Ceholski, Roger J. Hajjar, Francesca Stillitano, Evangelia G. Kranias, Erik Kohlbrenner
Publikováno v:
Circulation
Background: Arginine (Arg) 14 deletion (R14del) in the calcium regulatory protein phospholamban (hPLN R14del ) has been identified as a disease-causing mutation in patients with an inherited cardiomyopathy. Mechanisms underlying the early arrhythmoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a13f1e134288ccc921bfdd10f9ea78
https://doi.org/10.1161/circulationaha.119.043502
https://doi.org/10.1161/circulationaha.119.043502
Autor:
Olympia Bikou, Serena Tharakan, Kelly P. Yamada, Taro Kariya, Jaume Aguero, Alexandra Gordon, Renata Mazurek, Tadao Aikawa, Erik Kohlbrenner, Kenneth M. Fish, Roger J. Hajjar, Kiyotake Ishikawa
Publikováno v:
Hum Gene Ther
A disappointing number of new therapies for pulmonary hypertension (PH) have been successfully translated to the clinic. Adeno-associated viral (AAV) gene therapy has the potential to treat the underlying pathology of PH, but the challenge remains in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff2f21f480bba1ae09cbaa28f6a738
https://europepmc.org/articles/PMC9142769/
https://europepmc.org/articles/PMC9142769/
Autor:
Sima T. Tarzami, Lahouaria Hadri, Carly Jones, Michael G. Katz, Erik Kohlbrenner, Malik Bisserier, Yassine Abdeldjebbar, Julio Cortijo, Jane A. Leopold, Roger J. Hajjar, Sarah M. Gubara, Elena Chepurko, Javier Milara, Carlos Bueno-Beti, Yassine Sassi
Publikováno v:
Mol Ther
Inhibition of pulmonary fibrosis (PF) by restoring sarco/endoplasmic reticulum calcium ATPase 2a isoform (SERCA2a) expression using targeted gene therapy may be a potentially powerful new treatment approach for PF. Here, we found that SERCA2a express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af386ca1bd609b36edf5a1628757c4f4
https://doi.org/10.1016/j.ymthe.2019.11.027
https://doi.org/10.1016/j.ymthe.2019.11.027
Autor:
Rajvir Singh, Erik Kohlbrenner, Prabhu Mathiyalagan, Roger J. Hajjar, Joshua Mayourian, Elena Chepurko, Marta Adamiak, Kiyotake Ishikawa, Divya Jha, Maria G. Trivieri, Shihong Zhang, Yaxuan Liang, Kenneth Fish, Rihab Bouchareb, Neha Agarwal, Susmita Sahoo, Jiqiu Chen, Djamel Lebeche, Yassine Sassi
Publikováno v:
Circulation. 139:518-532
Background: Despite its functional importance in various fundamental bioprocesses, studies of N 6 -methyladenosine (m6A) in the heart are lacking. Here, we show that the FTO (fat mass and obesity-associated protein), an m6A demethylase, plays a criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dfbb738ad94183b32bf2a230eb7deed
https://doi.org/10.1161/circulationaha.118.033794
https://doi.org/10.1161/circulationaha.118.033794