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pro vyhledávání: '"Erik Klontz"'
Autor:
Beatriz Trastoy, Erik Klontz, Jared Orwenyo, Alberto Marina, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Endoglycosidase S only recognizes one particular type of glycan within IgG antibodies but the molecular basis for this high specificity is not fully understood. Here, the authors present the crystal structure of product-bound Endoglycosidase S, revea
Externí odkaz:
https://doaj.org/article/733a7aaf8d0e4ff182ca5cc6f40ca189
Autor:
Erik Klontz, Juliet O. Obi, Yajing Wang, Gabrielle Glendening, Jahid Carr, Constantine Tsibouris, Sahthi Buddula, Shreeram Nallar, Alexei S. Soares, Dorothy Beckett, Jasmina S. Redzic, Elan Eisenmesser, Cheyenne Palm, Katrina Schmidt, Alexis H. Scudder, Trinity Obiorah, Kow Essuman, Jeffrey Milbrandt, Aaron Diantonio, Krishanu Ray, Daniel Deredge, M LD. Snyder, Greg A. Snyder
Toll-like and Interleukin-1/18 receptor resistance (TIR) domain-containing proteins function as important signaling and immune regulatory molecules. TIR domain-containing proteins identified in eukaryotic and prokaryotic species also exhibit NAD+ hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95374451370e60151b3cff10b9ddcf36
https://doi.org/10.1101/2023.05.19.541320
https://doi.org/10.1101/2023.05.19.541320
Autor:
Erik Klontz
Publikováno v:
Transfusion medicine reviews. 36(4)
The discovery of bacterial enzymes with specificity for IgG antibodies has led to breakthroughs in several autoantibody-mediated diseases. Two such enzymes, IdeS and EndoS, degrade IgG by different mechanisms, and have separately shown promise in num