Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Erik K, Flemington"'
Autor:
Justin W. Magrath, Dane A. Flinchum, Alifiani B. Hartono, Shruthi Sanjitha Sampath, Tina M. O’Grady, Melody Baddoo, Liang Haoyang, Xiaojiang Xu, Erik K. Flemington, Sean B. Lee
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-15 (2024)
Abstract Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. The tumor is refractory to treatment with a 5-year survival rate of only 15–25%, necessitating the development of nov
Externí odkaz:
https://doaj.org/article/a8a2471577974e2b8bcfdaa509733192
Autor:
Firas Safa, Terri Rasmussen, Patricia Lobelle‐Rich, Stephanie Collier, Nicholas Milligan, John Schmeig, Janet Schmid, Carol Wiewiorowski, Denise Totaro, Theresa C. Brown, Ishwarya Satyavarapu, Melody Badoo, Nathan Ungerleider, Erik K. Flemington, Hana Safah, Nakhle S. Saba
Publikováno v:
eJHaem, Vol 3, Iss 4, Pp 1326-1329 (2022)
Abstract Cell lines represent an essential tool used in preclinical research. Most hematologic malignancies have a wide array of cell lines representing their respective molecular and pathologic spectra. In mantle cell lymphoma (MCL), cell lines beco
Externí odkaz:
https://doaj.org/article/e441dd4eaabe4c8d91140a14066ab3ad
Autor:
Firas M. Safa, Terri Rasmussen, Lorena Fontan, Min Xia, Ari Melnick, Adrian Wiestner, Patricia Lobelle-Rich, Jan A. Burger, Yara Mouawad, Hana Safah, Erik K. Flemington, Nakhle S. Saba
Publikováno v:
Haematologica, Vol 109, Iss 5 (2023)
B-cell acute lymphoblastic leukemia (B-ALL) remains a hard-to-treat disease with a poor prognosis in adults. Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a para-caspase required for B-cell receptor (BCR)-mediated NF-
Externí odkaz:
https://doaj.org/article/7a403361604b4b78a65a32aa7c2478d9
Autor:
Tina M. O’Grady, Melody Baddoo, Samuel A. Flemington, Eman Y. Ishaq, Nathan A. Ungerleider, Erik K. Flemington
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionB cell activation and differentiation is central to the adaptive immune response. Changes in exon usage can have major impacts on cellular signaling and differentiation but have not been systematically explored in differentiating B cells.
Externí odkaz:
https://doaj.org/article/9ddc30d1071c41caa874aa80b3fa81b5
Autor:
Jung-Hyun Kim, Kyuho Jeong, Jianfeng Li, James M. Murphy, Lana Vukadin, Joshua K. Stone, Alexander Richard, Johnny Tran, G. Yancey Gillespie, Erik K. Flemington, Robert W. Sobol, Ssang-Teak Steve Lim, Eun-Young Erin Ahn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Splicing factor PTBP1 is reported to promote oncogenic functions in glioblastoma (GBM). Here the authors show splicing factor SON upregulates PTBP1 expression while supresses its paralog PTBP2 through alternative splicing and the inhibition of SON re
Externí odkaz:
https://doaj.org/article/ef70cfa927e24e59962a148691be73fd
Autor:
Yiping Wang, Nathan Ungerleider, Brett A. Hoffman, Mehmet Kara, Paul J. Farrell, Erik K. Flemington, Nara Lee, Scott A. Tibbetts
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT The oncogenic gammaherpesviruses, including human Epstein-Barr virus (EBV), human Kaposi’s sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 (MHV68, γHV68, MuHV-4), are associated with numerous malignancies, including
Externí odkaz:
https://doaj.org/article/de5adf09edba4553a868898285dbdbf5
Autor:
Qinyan Yin, Michael J. Strong, Yan Zhuang, Erik K. Flemington, Naftali Kaminski, Joao A. de Andrade, Joseph A. Lasky
Publikováno v:
BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Numerous publications suggest an association between herpes virus infection and idiopathic pulmonary fibrosis (IPF). These reports have employed immunohistochemistry, in situ hybridization and/or PCR, which are susceptible to spec
Externí odkaz:
https://doaj.org/article/c0d9633dd7e040e2b1a124f8a42f37e3
Autor:
Nathan Ungerleider, Whitney Bullard, Mehmet Kara, Xia Wang, Claire Roberts, Rolf Renne, Scott Tibbetts, Erik K Flemington
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009217 (2021)
The Epstein Barr virus (EBV) contributes to the tumor phenotype through a limited set of primarily non-coding viral RNAs, including 31 mature miRNAs. Here we investigated the impact of EBV miRNAs on remodeling the tumor cell transcriptome. Strikingly
Externí odkaz:
https://doaj.org/article/125eb20df3264987b2591a0c8ed0096e
Publikováno v:
Data in Brief, Vol 34, Iss , Pp 106774- (2021)
These data include secondary analysis of publicly available RNA-seq data from castration-resistant prostate cancer (CRPC) patients as well as RT-qPCR and Western blotting analyses of patient-derived xenograft models and a CRPC cell line. We applied S
Externí odkaz:
https://doaj.org/article/5ee0fdff56c3482a99721247b5a2885d
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-21 (2018)
Abstract Background Bacterial invasive infection and host immune response is fundamental to the understanding of pathogen pathogenesis and the discovery of effective therapeutic drugs. However, there are very few experimental studies on the signaling
Externí odkaz:
https://doaj.org/article/ca621acce1ab4abc9268f01fdebabf2e