Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Erik J, Tokar"'
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Detrimental side effects of drugs like doxorubicin, which can cause cardiotoxicity, pose barriers for preventing cancer progression, or treating cancer early through molecular interception. Extracellular vesicles (EVs) are valued for their potential
Externí odkaz:
https://doaj.org/article/3518213d065c46bc8bafbe8c4f43d3fc
Autor:
Birandra K. Sinha, Carri Murphy, Shalyn M. Brown, Brian B. Silver, Erik J. Tokar, Carl D. Bortner
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8666 (2024)
Erastin (ER) induces cell death through the formation of reactive oxygen species (ROS), resulting in ferroptosis. Ferroptosis is characterized by an accumulation of ROS within the cell, leading to an iron-dependent oxidative damage-mediated cell deat
Externí odkaz:
https://doaj.org/article/a33b4a2befa54b859837147a9be180b0
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5522 (2024)
Early detection of neurological conditions is critical for timely diagnosis and treatment. Identifying cellular-level changes is essential for implementing therapeutic interventions prior to symptomatic disease onset. However, monitoring brain tissue
Externí odkaz:
https://doaj.org/article/b088778ac42c448ea0ee901aede530ed
Autor:
Birandra K. Sinha, Carl D. Bortner, Alan K. Jarmusch, Erik J. Tokar, Carri Murphy, Xian Wu, Heather Winter, Ronald E. Cannon
Publikováno v:
Cells, Vol 12, Iss 12, p 1626 (2023)
Our recent studies show that the treatment of human ovarian tumor cells with NCX4040 results in significant depletions of cellular glutathione, the formation of reactive oxygen/nitrogen species and cell death. NCX4040 is also cytotoxic to several hum
Externí odkaz:
https://doaj.org/article/a81615ed59ff4015be0775e09dc25c83
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8611 (2022)
NCX4040, the non-steroidal anti-inflammatory-NO donor, is cytotoxic to several human tumors, including ovarian tumor cells. We have found that NCX4040 is also cytotoxic against both OVCAR-8 and its adriamycin resistant (NCI/ADR-RES) tumor cell lines.
Externí odkaz:
https://doaj.org/article/d336677b88a04e988e34e4596c497d9c
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Topotecan is a clinically active anticancer agent for the management of various human tumors. While the principal mechanism of tumor cell killing by topotecan is due to its interactions with topoisomerase I and formation of DNA double-strand breaks,
Externí odkaz:
https://doaj.org/article/c25a76f6c56f48c4b58eabcf43ce86fc
Autor:
Cannon, Birandra K. Sinha, Carl D. Bortner, Alan K. Jarmusch, Erik J. Tokar, Carri Murphy, Xian Wu, Heather Winter, Ronald E.
Publikováno v:
Cells; Volume 12; Issue 12; Pages: 1626
Our recent studies show that the treatment of human ovarian tumor cells with NCX4040 results in significant depletions of cellular glutathione, the formation of reactive oxygen/nitrogen species and cell death. NCX4040 is also cytotoxic to several hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::9cccc6d1be4a8f9aa20cf4ee4bf4f15e
Autor:
Douglas Ganini, Fabian Leinisch, Ashutosh Kumar, JinJie Jiang, Erik J. Tokar, Christine C. Malone, Robert M. Petrovich, Ronald P. Mason
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 462-468 (2017)
Fluorescent proteins are an important tool that has become omnipresent in life sciences research. They are frequently used for localization of proteins and monitoring of cells [1,2]. Green fluorescent protein (GFP) was the first and has been the most
Externí odkaz:
https://doaj.org/article/4d28840fee684b458aa130ee994b626a
Autor:
Birandra Kumar Sinha, Carl D Bortner, Alan K Jatmusch, Erik J Tokar, Carri Murphey, Xian Wu, Heather Winter, Ronald E Cannon
Our recent studies showed that the treatment of human ovarian tumor cells with NCX4040 resulted in significant depletions of cellular glutathione, formation of reactive oxygen/nitrogen species and cell death. NCX4040 is also cytotoxic to several huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16c034952c57ad15038c6e76e7e09baf
https://doi.org/10.20944/preprints202305.1679.v1
https://doi.org/10.20944/preprints202305.1679.v1
Publikováno v:
Genomic and Epigenomic Biomarkers of Toxicology and Disease. :395-413
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b344573aec42bae94b164a51078ad472
https://doi.org/10.1002/9781119807704.ch18
https://doi.org/10.1002/9781119807704.ch18