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OR13-2 Characterizing the Impact of Burosumab on Bone Health in Children with X-Linked Hypophosphatemia: Results from Year 1 of the Disease Monitoring Program

Autor: Thomas Carpenter, Hamilton Cassinelli, Francis Glorieux, Joel Hetzer, J Lawrence Merritt II, Carolina A Moreira, Anthony Portale, Leanne Ward, Claudine Woo, Erik Imel

Publikováno v: Journal of the Endocrine Society. 6:A191-A192

X-linked hypophosphatemia (XLH) is a rare, heritable disorder wherein excess FGF23 leads to renal phosphate wasting and impaired activation of vitamin D. XLH is characterized by rickets and osteomalacia leading to bone pain, skeletal deformities, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da78c9ede284631124c81d2faab01fb8
https://doi.org/10.1210/jendso/bvac150.395

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Sustained efficacy and safety of burosumab, a fully human anti-FGF23 monoclonal antibody, in children and early adolescents with X-linked hypophosphatemia

Autor: Wolfgang Hogler, Thomas Carpenter, Erik Imel, Anthony Portale, Annemieke Boot, Agnes Linglart, Raja Padidela, William van't Hoff, Meng Mao, Alison Skrinar, Javier San Martin, Michael Whyte

Publikováno v: Bone Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::560dfbe94ee20f19fcf5eaced92baf0e
https://doi.org/10.1530/boneabs.7.oc15

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A randomized, open-label Phase 2 study of KRN23, an investigational fully human Anti-FGF23 monoclonal antibody, in children with X-linked Hypophosphatemia (XLH)

Autor: Wolfgang Hogler, Anthony Portale, Erik Imel, Annemieke Boot, Agnes Linglart, Raja Padidela, Hoff William van't, Michael Whyte, Meng Mao, Alison Skrinar, Javier San Martin, Thomas Carpenter

Publikováno v: Bone Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21ca6af8f5a3e5b892f74a879e88f0df
https://doi.org/10.1530/boneabs.6.oc26

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Effects of KRN23, a fully human anti-FGF23 monoclonal antibody, on functional outcomes in children with X-linked hypophosphatemia (XLH): results from a randomized, open-label Phase 2 study

Autor: Erik Imel, Thomas Carpenter, Agnes Linglart, Annemieke Boot, Wolfgang Hogler, Raja Padidela, Hoff William van't, Anthony Portale, Meng Mao, Alison Skrinar, Martin Javier San, Michael P Whyte

Publikováno v: Bone Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ec4412cde5ef3d7019c9f60886cb106
https://doi.org/10.1530/boneabs.6.p063

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Effects of KRN23, a fully human anti-FGF23 monoclonal antibody, on functional outcomes in children with x-linked hypophosphatemia (XLH): results from a randomized, open-label phase 2 study

Autor: Erik Imel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b756de6e238c98e9cb38cf770902c642
https://doi.org/10.26226/morressier.59020064d462b80292385cbe

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Effect of KRN23, a fully human anti-FGF23 monoclonal antibody, on rickets in children with X-linked hypophosphatemia (XLH): 40-week interim results from a randomized, open-label phase 2 study

Autor: Raja Padidela, Hoff William van't, Wolfgang Hogler, Anthony Portale, Erik Imel, Annemieke Boot, Agnes Linglart, Michael Whyte, Alison Skrinar, Martin Javier San, Thomas Carpenter

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55775ee86b97bd50a2b07dbe6c8ccda9
https://doi.org/10.1530/endoabs.45.oc5.1

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Atypical femur fractures (AFF): a case-control study

Autor: Erik Imel, George Eckert, Katie Allen, Julie Chandler, Joel Martin, Siu Hui, C Conrad Johnston, Anne DePapp, Art Santora, Robert Choplin, Trenton Roth, Ziyue Liu

Publikováno v: Bone Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93ef995a91b78df3d5aea9f5abf44236
https://doi.org/10.1530/boneabs.5.p352

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