Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Erik I Tucker"'
Autor:
Norah G. Verbout, Christina U. Lorentz, Brandon D. Markway, Michael Wallisch, Thomas C. Marbury, Enrico Di Cera, Joseph J. Shatzel, András Gruber, Erik I. Tucker
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-11 (2024)
Abstract Background The protein C system regulates blood coagulation, inflammation, and vascular integrity. AB002 is an injectable protein C activating enzyme under investigation to safely prevent and treat thrombosis. In preclinical models, AB002 is
Externí odkaz:
https://doaj.org/article/de9625889c004a0a9813402404b9f1bc
Autor:
Charles E Bane, Ivan Ivanov, Anton Matafonov, Kelli L Boyd, Qiufang Cheng, Edward R Sherwood, Erik I Tucker, Stephen T Smiley, Owen J T McCarty, Andras Gruber, David Gailani
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152968 (2016)
Sepsis, a systemic inflammatory response to infection, is often accompanied by abnormalities of blood coagulation. Prior work with a mouse model of sepsis induced by cecal ligation and puncture (CLP) suggested that the protease factor XIa contributed
Externí odkaz:
https://doaj.org/article/15e4234e34084d13b6001a61916bc58a
Autor:
Cristina Puy, Erik I Tucker, Ivan S Ivanov, David Gailani, Stephanie A Smith, James H Morrissey, András Gruber, Owen J T McCarty
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165172 (2016)
Factor (F) XI supports both normal human hemostasis and pathological thrombosis. Activated FXI (FXIa) promotes thrombin generation by enzymatic activation of FXI, FIX, FX, and FV, and inactivation of alpha tissue factor pathway inhibitor (TFPIα), in
Externí odkaz:
https://doaj.org/article/06e4f33d43fd4c97906541e2f66d3168
Autor:
Toshiaki Shirai, Alexey S. Revenko, Justin Tibbitts, Anh T.P. Ngo, Annachiara Mitrugno, Laura D. Healy, Jennifer Johnson, Erik I. Tucker, Monica T. Hinds, Lisa M. Coussens, Owen J.T. McCarty, Brett P. Monia, András Gruber
Publikováno v:
Blood Advances, Vol 3, Iss 20, Pp 3080-3091 (2019)
Abstract: In humans, platelet count within the normal range is required for physiological hemostasis, but, adversely, platelets also support pathological thrombosis. Moreover, by releasing growth factors, they may enhance neoplastic proliferation. We
Externí odkaz:
https://doaj.org/article/4c4e4254f9bf4a1ba88e8704d6fc1b2e
Autor:
Maxim Litvak, Aleksandr Shamanaev, Sandip Zalawadiya, Anton Matafonov, Anton Kobrin, Edward P. Feener, Michael Wallisch, Erik I. Tucker, Owen J.T. McCarty, David Gailani
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:1200-1213
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ed16bbc3d87592ae97a6207f8d0c22
https://doi.org/10.1016/j.jtha.2022.12.014
https://doi.org/10.1016/j.jtha.2022.12.014
Autor:
Christina U. Lorentz, Norah G. Verbout, Zhiping Cao, Lijuan Liu, Monica T. Hinds, Owen J.T. McCarty, Ivan Ivanov, Erik I. Tucker, David Gailani, András Gruber
Publikováno v:
Blood Advances, Vol 2, Iss 2, Pp 85-88 (2018)
Externí odkaz:
https://doaj.org/article/b60d992154bb4a649a7315543477f23f
Autor:
Kelley R. Jordan, Cory R. Wyatt, Meghan E. Fallon, Randy Woltjer, Edward A. Neuwelt, Quifang Cheng, David Gailani, Christina Lorentz, Erik I. Tucker, Owen J.T. McCarty, Monica T. Hinds, Khanh P. Nguyen
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2035-2045
Deep vein thrombosis (DVT) and post-thrombotic syndrome (PTS) remain highly prevalent despite modern medical therapy. Contact activation is a promising target for safe antithrombotic anticoagulation. The anti-factor XI (FXI) monoclonal antibody 14E11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec300a9edf62cb7c9c4102d2bd2c4be4
https://doi.org/10.1111/jth.15777
https://doi.org/10.1111/jth.15777
Autor:
Norah G Verbout, Weiping Su, Peter Pham, Kelley Jordan, Tia CL Kohs, Erik I Tucker, Owen JT McCarty, Larry S Sherman
Objective: Relapses in patients with relapsing-remitting multiple sclerosis (RRMS) are typically treated with high-dose corticosteroids including methylprednisolone. However, high-dose corticosteroids are associated with significant adverse effects,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7aec55878f828eb974f415cbe635e50
https://doi.org/10.21203/rs.3.rs-2802415/v1
https://doi.org/10.21203/rs.3.rs-2802415/v1
Autor:
Michael A Pfeffer, Helen Vu, Tia CL Kohs, Jenny Wang, Christina U Lorentz, Erik I Tucker, Sven R Olson, Thomas G Deloughery, Monica T Hinds, Owen JT McCarty, Joseph J Shatzel
Publikováno v:
Blood. 140:1247-1249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24cd8d2550cb90fb3156ba6f9c394f69
https://doi.org/10.1182/blood-2022-170429
https://doi.org/10.1182/blood-2022-170429
Autor:
Leonid A Parunov, Yideng Liang, Qijin Lu, Alexey M Shibeko, Erik I. Tucker, Timothy K. Lee, Fazoil I Ataullakhanov, Dorothy Scott, Mikhail V Ovanesov
Publikováno v:
Blood Advances.
Inhibitors of coagulation factor (F) XIa are currently investigated as potential anticoagulant therapies. We hypothesized that circulating FXIa may be a potential target for these therapies. Using previous analyses of FXIa impurity in immune globulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25761cdb087100a2c10a3455f6660c82
https://doi.org/10.1182/bloodadvances.2022008743
https://doi.org/10.1182/bloodadvances.2022008743