Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications

Autor: Christer Nilsson, Fredrika Linde, Erik Hulegårdh, Hege Garelius, Vladimir Lazarevic, Petar Antunovic, Jörg Cammenga, Stefan Deneberg, Anna Eriksson, Martin Jädersten, Cecilia Kämpe Björkvall, Lars Möllgård, Lovisa Wennström, Emma Ölander, Martin Höglund, Gunnar Juliusson, Sören Lehmann

Publikováno v: Haematologica, Vol 108, Iss 4 (2022)

Studies of therapy-related AML (t-AML) are usually performed in selected cohorts and reliable incidence rates are lacking. In this study, we characterized, defined the incidence over time and studied prognostic implications in all t-AML patients diag

Externí odkaz: https://doaj.org/article/f65464ab1d8c4e48807a6b185d655723

Secondary Acute Myeloid Leukemia and the Role of Allogeneic Stem Cell Transplantation in a Population-Based Setting

Autor: Lars Möllgård, Erik Hulegårdh, Gunnar Juliusson, Dick Stockelberg, Ulla Frödin, Martin Höglund, Anders Wahlin, Stig Lenhoff, Sören Lehmann, Mats Brune, Mats Remberger, Hege Garelius, Christer Nilsson

Publikováno v: Biology of Blood and Marrow Transplantation. 25:1770-1778

Secondary AML (s-AML), including AML with an antecedent hematologic disorder (AHD-AML) and therapy-related AML (t-AML), constitutes a large proportion of patients with AML and is considered to confer a dismal prognosis. The role of allogeneic hematop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70390b087149ad354ec7543a940ae0c3
https://doi.org/10.1016/j.bbmt.2019.05.038

NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia

Autor: Erik Hulegårdh, Bendik Lund, Marie Grosjean, Ramneek Gupta, Morten Tulstrup, William L. Carroll, Kaie Pruunsild, Jacob Nersting, Zeyu Zhang, Marlene Danner Dalgaard, Nina Toft, Peder Skov Wegener, Mari Punab, Goda Vaitkeviciene, Jinhua Wang, Kathrine Grell, Stine Nygaard Nielsen, Sigurd Liestol, Olafur G. Jonsson, Benjamin Ole Wolthers, Laimonas Griskevicius, Arja Harila-Saari, Jonas Abrahamsson, Mette Holm, Kjeld Schmiegelow

Publikováno v: Tulstrup, M, Grosjean, M, Nielsen, S N, Grell, K, Wolthers, B O, Wegener, P S, Jonsson, O G, Lund, B, Harila-Saari, A, Abrahamsson, J, Vaitkeviciene, G, Pruunsild, K, Toft, N, Holm, M, Hulegårdh, E, Liestøl, S, Griskevicius, L, Punab, M, Wang, J, Carroll, W L, Zhang, Z, Dalgaard, M D, Gupta, R, Nersting, J & Schmiegelow, K 2018, ' NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia ', Leukemia, vol. 32, no. 12, pp. 2527–2535 . https://doi.org/10.1038/s41375-018-0245-3
Tulstrup, M, Grosjean, M, Nielsen, S N, Grell, K, Wolthers, B O, Wegener, P S, Jonsson, O G, Lund, B, Harila-Saari, A, Abrahamsson, J, Vaitkeviciene, G, Pruunsild, K, Toft, N, Holm, M, Hulegårdh, E, Liestøl, S, Griskevicius, L, Punab, M, Wang, J, Carroll, W L, Zhang, Z, Dalgaard, M D, Gupta, R, Nersting, J & Schmiegelow, K 2018, ' NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia ', Leukemia, vol. 32, no. 12, pp. 2527-2535 . https://doi.org/10.1038/s41375-018-0245-3

The antileukaemic drug 6-mercaptopurine is converted into thioguanine nucleotides (TGN) and incorporated into DNA (DNA-TG), the active end metabolite. In a series of genome-wide association studies, we analysed time-weighted means (wm) of erythrocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf51d044bbd21434cfe199ab46207ed
https://pubmed.ncbi.nlm.nih.gov/30201983

Characterization and prognostic features of secondary acute myeloid leukemia in a population-based setting: A report from the Swedish Acute Leukemia Registry

Autor: Anders Wahlin, Vladimir Lazarevic, Lovisa Wennström, Sören Lehmann, Lars Möllgård, Erik Hulegårdh, Åsa Rangert Derolf, Hege Garelius, Gunnar Juliusson, Christer Nilsson, Petar Antunovic, Bertil Uggla, Dick Stockelberg, Martin Höglund

Publikováno v: American Journal of Hematology. 90:208-214

Patients with secondary acute myeloid leukemia (AML) often escape inclusion in clinical trials and thus, population-based studies are crucial for its accurate characterization. In this first large population-based study on secondary AML, we studied A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cdf8abf13deaa64bc68f73f1183c6fa
https://doi.org/10.1002/ajh.23908

High relapse rate of T cell acute lymphoblastic leukemia in adults treated with Hyper-CVAD chemotherapy in Sweden

Autor: Piotr Kozlowski, Alicja Markuszewska-Kuczymska, Karin Karlsson, Hans Hägglund, Helene Hallböök, Maria Åström, Rose-Marie Amini, Erik Hulegårdh, Bengt Smedmyr, Per Bernell, Beata Tomaszewska-Toporska, Lucia Ahlberg

Publikováno v: European Journal of Haematology. 92:377-381

Background Hyper-CVAD is widely used to treat acute lymphoblastic leukemia (ALL) and aggressive lymphomas. This multicenter, population-based study assessed the efficacy of Hyper-CVAD as first-line therapy in patients with T-cell ALL (T-ALL). Patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ab22fba0bbf7ff1ce0a15489cbe89f
https://doi.org/10.1111/ejh.12269