Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Erik Hoffmann"'
Autor:
Bianca Wiedemann, Dominic Kamps, Laura Depta, Jörn Weisner, Jana Cvetreznik, Stefano Tomassi, Sascha Gentz, Jan-Erik Hoffmann, Matthias P Müller, Oliver Koch, Leif Dehmelt, Daniel Rauh
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0267651 (2022)
Misregulation and mutations of the transcription factor Nrf2 are involved in the development of a variety of human diseases. In this study, we employed the technology of stapled peptides to address a protein-DNA-complex and designed a set of Nrf2-bas
Externí odkaz:
https://doaj.org/article/dbca67447fa2492090e99bbeedfdd082
Autor:
Jana Flegel, Saad Shaaban, Zhi Jun Jia, Britta Schulte, Yilong Lian, Adrian Krzyzanowski, Malte Metz, Tabea Schneidewind, Fabian Wesseler, Anke Flegel, Alisa Reich, Alexandra Brause, Gang Xue, Minghao Zhang, Lara Dötsch, Isabelle D. Stender, Jan-Erik Hoffmann, Rebecca Scheel, Petra Janning, Fraydoon Rastinejad, Dennis Schade, Carsten Strohmann, Andrey P. Antonchick, Sonja Sievers, Pedro Moura-Alves, Slava Ziegler, Herbert Waldmann
Publikováno v:
Journal of Medicinal Chemistry. 65:16268-16289
Identification and analysis of small molecule bioactivity in target-agnostic cellular assays and monitoring changes in phenotype followed by identification of the biological target are a powerful approach for the identification of novel bioactive che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be09301612a26f71d7b6806277269021
https://doi.org/10.1021/acs.jmedchem.2c00956
https://doi.org/10.1021/acs.jmedchem.2c00956
Autor:
Jan-Erik Hoffmann
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 578 (2020)
Genetic code expansion is a powerful tool for the study of protein interactions, as it allows for the site-specific incorporation of a photoreactive group via non-canonical amino acids. Recently, several groups have published bifunctional amino acids
Externí odkaz:
https://doaj.org/article/1b053f72253d4ab891f070f4a682ffec
Autor:
Doris Urlaub, Natalie Wolfsdorff, Jan‐Erik Hoffmann, Stefanie Dorok, Markus Hoffmann, Moritz Anft, Naomi Pieris, Patrick Günther, Bernhard Schaaf, Uwe Cassens, Peter Bröde, Maren Claus, Lea K. Picard, Sabine Wingert, Simone Backes, Deniz Durak, Nina Babel, Stefan Pöhlmann, Frank Renken, Stefan Raunser, Carsten Watzl
Publikováno v:
European journal of immunology, 52(5):810-815
Neutralizing antibodies against SARS-CoV-2 are important to protect against infection and/or disease. Using an assay to detect antibodies directed against the receptor binding domain (RBD) of SARS-CoV-2 Spike, we identified individuals with SARS-CoV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a09bae60f6c3c05d38b532f2443191c
Wiley Online Library
Wiley Online Library
Autor:
Wolfgang Gehra, Erik Hoffmann
Publikováno v:
Intrapreneurship ISBN: 9783662641019
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0252e29ed35f4ee312a39a63d9eaf6a
https://doi.org/10.1007/978-3-662-64102-6_4
https://doi.org/10.1007/978-3-662-64102-6_4
Autor:
Simran Goel, Rosario Oliva, Sadasivam Jeganathan, Verian Bader, Laura J Krause, Simon Kriegler, Isabelle D Stender, Chadwick W Christine, Ken Nakamura, Jan-Erik Hoffmann, Roland Winter, Jörg Tatzelt, Konstanze F Winklhofer
Publikováno v:
Life Science Alliance. 6:e202201607
The NF-κB essential modulator NEMO is the core regulatory component of the inhibitor of κB kinase complex, which is a critical checkpoint in canonical NF-κB signaling downstream of innate and adaptive immune receptors. In response to various stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba4d4851e8a967a2117e88507646fd7f
https://doi.org/10.26508/lsa.202201607
https://doi.org/10.26508/lsa.202201607
Biogene flüchtige organische Verbindungen (BVOCs) sind allgegenwärtig, vielfältig und werden in der Atmosphäre sehr schnell oxidiert. BVOCs werden in großen Mengen durch Pflanzen, insbesondere Bäume, emittiert. Zu den BVOCs gehören Isopren, ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::945a16978b4be5ed2c590e4f90c466bc
https://doi.org/10.5194/dach2022-35
https://doi.org/10.5194/dach2022-35
Publikováno v:
Chembiochem
Ultraviolent crosslinking is a key experimental step in the numerous protocols that have been developed for capturing and dissecting RNA–protein interactions in living cells. UV crosslinking covalently stalls dynamic interactions between RNAs and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06fc3f1c99b9e8786a9a6b2d1621af5
https://doi.org/10.1002/cbic.201900559
https://doi.org/10.1002/cbic.201900559
Publikováno v:
eLife, Vol 3 (2014)
How can the integrin adhesome get self-assembled locally, rapidly, and correctly as diverse cell-matrix adhesion sites? Here, we investigate this question by exploring the cytosolic state of integrin-adhesome components and their dynamic exchange bet
Externí odkaz:
https://doaj.org/article/704780f6d78f4956a5bd02c97cef25d0
Publikováno v:
Biochemistry. 57:4747-4752
Mapping of weak and hence transient interactions between low-abundance interacting molecules is still a major challenge in systems biology and protein biochemistry. Therefore, additional system-wide acting tools are needed to determine protein intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db0afc31c9959978e12b3016e50ad2c
https://doi.org/10.1021/acs.biochem.8b00397
https://doi.org/10.1021/acs.biochem.8b00397