Rationally designed chemical modulators convert a bacterial channel protein into a pH-sensory valve

Autor: Wim Meijberg, Armagan Kocer, Erik Halza, Bernard Feringa, Erna Bulten, Martin Walko

Publikováno v: Angewandte Chemie-International Edition, 45(19), 3126-3130. Wiley
Angewandte Chemie-International Edition, 45(19), 3126-3130. WILEY-V C H VERLAG GMBH

Open channels: Chemical modulators are developed to convert a naturally occurring channel protein into a pH-actuated nanovalve. The pH interval, sensitivity, and activation of the valve by channel opening are tunable through the design of the modulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152c7c4843a19ff70eb8d07feda71a82
https://research.rug.nl/en/publications/3c2be644-cf7a-4405-a30c-105f1513142d

Probing the SecYEG translocation pore size with preproteins conjugated with sizable rigid spherical molecules

Autor: Arnold J. M. Driessen, Francesco Bonardi, Martin Walko, Nico Nouwen, Ben L. Feringa, Erik Halza, François Du Plessis

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 108(19), 7775-7780. NATL ACAD SCIENCES

Protein translocation in Escherichia coli is mediated by the translocase that in its minimal form consists of the protein-conducting channel SecYEG, and the motor protein, SecA. SecYEG forms a narrow pore in the membrane that allows passage of unfold

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772769f5e533ca46389aebb4b8e6104f
https://pubmed.ncbi.nlm.nih.gov/21518907