Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Erik H. Klontz"'
Autor:
Beatriz Trastoy, Jonathan J. Du, Javier O. Cifuente, Lorena Rudolph, Mikel García-Alija, Erik H. Klontz, Daniel Deredge, Nazneen Sultana, Chau G. Huynh, Maria W. Flowers, Chao Li, Diego E. Sastre, Lai-Xi Wang, Francisco Corzana, Alvaro Mallagaray, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Here, the authors establish the mechanisms of recognition and specific deglycosylation of IgG antibodies by
Externí odkaz:
https://doaj.org/article/7aed46f3a16540f68a93f7c72eef2df7
Autor:
Erik H. Klontz, Chao Li, Kyle Kihn, James K. Fields, Dorothy Beckett, Greg A. Snyder, Patrick L. Wintrode, Daniel Deredge, Lai-Xi Wang, Eric J. Sundberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
AlfC transfucosidase is used to modulate fucosylation of glycans decorating monoclonal antibodies. Herein, structural and biophysical characterization reveals the enzymatic mechanism of AlfC and a blueprint for the design of AlfC mutants with novel s
Externí odkaz:
https://doaj.org/article/9a30450512214f37b47bbcf6f541a3c3
Autor:
Beatriz Trastoy, Jonathan J. Du, Erik H. Klontz, Chao Li, Javier O. Cifuente, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Human gut bacteria depolymerize glycans into their sugar components, which otherwise cannot be processed by their host. Here, the authors characterise the endo-β-N-acetylglucosaminidase EndoBT-3987 from the Gram-negative symbiont Bacteroides thetaio
Externí odkaz:
https://doaj.org/article/0967fd4440514038b204e0c6670b530c
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor
Autor:
James K. Fields, Kyle Kihn, Gabriel S. Birkedal, Erik H. Klontz, Kjell Sjöström, Sebastian Günther, Robert Beadenkopf, Göran Forsberg, David Liberg, Greg A. Snyder, Daniel Deredge, Eric J. Sundberg
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myriad inflamma
Externí odkaz:
https://doaj.org/article/d1aa83cba4b9429da818f4c99e7a5c77
Autor:
Erik H. Klontz, Beatriz Trastoy, Daniel Deredge, James K. Fields, Chao Li, Jared Orwenyo, Alberto Marina, Robert Beadenkopf, Sebastian Günther, Jair Flores, Patrick L. Wintrode, Lai-Xi Wang, Marcelo E. Guerin, Eric J. Sundberg
Publikováno v:
ACS Central Science, Vol 5, Iss 3, Pp 524-538 (2019)
Externí odkaz:
https://doaj.org/article/004711398bcc42978684ed40020eff2d
Autor:
Nolan R Holbrook, Erik H Klontz, Gordon C Adams, Samuel R Schnittman, Nicolas C Issa, Sheila A Bond, John A Branda, Jacob E Lemieux
Publikováno v:
Open Forum Infectious Diseases. 10
We report Babesia microti genomic sequences with multiple mutations in the atovaquone-target region of cytochrome b, including a newly identified Y272S mutation, plus 1 mutation of undetermined significance in the azithromycin-associated ribosomal pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad6cce9bc41204d537d9a79a7637513c
https://doi.org/10.1093/ofid/ofad097
https://doi.org/10.1093/ofid/ofad097
Autor:
Jonathan J. Du, Diego Sastre, Beatriz Trastoy, Blaine Roberts, Daniel Deredge, Erik H. Klontz, Maria W. Flowers, Nazneen Sultana, Marcelo E. Guerin, Eric J. Sundberg
Publikováno v:
Methods in Molecular Biology ISBN: 9781071632420
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2732f3689d612d09f7b1df697146e8fb
https://doi.org/10.1007/978-1-0716-3243-7_10
https://doi.org/10.1007/978-1-0716-3243-7_10
Autor:
Nolan R. Holbrook, Erik H. Klontz, Gordon C. Adams, Samuel R. Schnittman, Nicolas C. Issa, Sheila A. Bond, John A. Branda, Jacob E. Lemieux
We reportBabesia microtigenomic sequences with multiple mutations in the atovaquone-target region of cytochrome b and the azithromycin-associated ribosomal protein L4, including newly identified mutations. The parasite was sequenced from an immunocom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cbe143918c6e3ac3e5dcbc5b2b1e4b5
https://doi.org/10.1101/2022.12.16.22283586
https://doi.org/10.1101/2022.12.16.22283586
Autor:
Beatriz Trastoy, Jonathan J. Du, Mikel García-Alija, Chao Li, Erik H. Klontz, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Curr Opin Struct Biol
Immunoglobulin G (IgG) monoclonal antibodies are a prominent and expanding class of therapeutics used for the treatment of diverse human disorders. The chemical composition of the N-glycan on the fragment crystallizable (Fc) region determines the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80772712ba5b2308c2dd48859881d082
https://pubmed.ncbi.nlm.nih.gov/34998123
https://pubmed.ncbi.nlm.nih.gov/34998123
Autor:
Daniel Deredge, Lai-Xi Wang, Dorothy Beckett, Greg A. Snyder, James K. Fields, Chao Li, Eric J. Sundberg, Kyle C. Kihn, Patrick L. Wintrode, Erik H. Klontz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Fucosylation is important for the function of many proteins with biotechnical and medical applications. Alpha-fucosidases comprise a large enzyme family that recognizes fucosylated substrates with diverse α-linkages on these proteins. Lactobacillus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25dd26979c865dcf929d22016baefd4
https://doi.org/10.1038/s41467-020-20044-z
https://doi.org/10.1038/s41467-020-20044-z