Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Erik H. J. G. Aarntzen"'
Autor:
Hans J. P. M. Koenen, Ilse J. E. Kouijzer, Michel de Groot, Steffie Peters, Daphne Lobeek, Evelien A. J. van Genugten, Dimitri A. Diavatopoulos, Nienke van Oosten, Sanne Gianotten, Mathias M. Prokop, Mihai G. Netea, Frank L. van de Veerdonk, Erik H. J. G. Aarntzen
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
The upper respiratory tract (URT) is the entry site for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), from where it further disseminates. Early and effective adaptive immune responses are crucial to restrict viral replication and limi
Externí odkaz:
https://doaj.org/article/ecdef4ca01694886916ee3759709b92d
Autor:
Evelien A. J. van Genugten, Theresa J. van Lith, Frederik M. A. van den Heuvel, Josee L. van Steenis, Romy M. ten Heggeler, Monique Brink, Laura Rodwell, Frederick J. A. Meijer, Daphne Lobeek, Wanda Hagmolen of ten Have, Frank L. van de Veerdonk, Mihai G. Netea, Mathias Prokop, Robin Nijveldt, Anil M. Tuladhar, Erik H. J. G. Aarntzen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract In coronavirus disease 2019 (COVID-19), endothelial cells play a central role and an inadequate response is associated with vascular complications. PET imaging with gallium-68 labelled RGD-peptide (68Ga-RGD) targets αvβ3 integrin expressio
Externí odkaz:
https://doaj.org/article/bcc7c129c3b34bbd9f343acf94db7819
Autor:
Irina Heid, Corinna Münch, Sinan Karakaya, Smiths S. Lueong, Alina M. Winkelkotte, Sven T. Liffers, Laura Godfrey, Phyllis F. Y. Cheung, Konstantinos Savvatakis, Geoffrey J. Topping, Florian Englert, Lukas Kritzner, Martin Grashei, Andrea Tannapfel, Richard Viebahn, Heiner Wolters, Waldemar Uhl, Deepak Vangala, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Daniel Rauh, Wilko Weichert, Jörg D. Hoheisel, Stephan A. Hahn, Franz Schilling, Rickmer Braren, Marija Trajkovic-Arsic, Jens T. Siveke
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) lacks effective treatment options beyond chemotherapy. Although molecular subtypes such as classical and QM (quasi-mesenchymal)/basal-like with transcriptome-based distinct signatures have b
Externí odkaz:
https://doaj.org/article/bde08f1443834615a3f9cb25e23e0e2b
Autor:
Johannes Schwenck, Manfred Kneilling, Niels P. Riksen, Christian la Fougère, Douwe J. Mulder, Riemer J. H. A. Slart, Erik H. J. G. Aarntzen
Publikováno v:
European Journal of Hybrid Imaging, Vol 6, Iss 1, Pp 1-16 (2022)
Abstract The detection of occult infections and low-grade inflammation in clinical practice remains challenging and much depending on readers’ expertise. Although molecular imaging, like [18F]FDG PET or radiolabeled leukocyte scintigraphy, offers q
Externí odkaz:
https://doaj.org/article/1010a0baffd24cc79a3cd66832c4813c
Autor:
Jan Marie de Gooyer, Fortuné M. K. Elekonawo, Andreas J. A. Bremers, Otto C. Boerman, Erik H. J. G. Aarntzen, Philip R. de Reuver, Iris. D. Nagtegaal, Mark Rijpkema, Johannes H. W. de Wilt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Imaging of tumor burden during surgery can lead to better tumor resection. Here, the authors develop a fluorescent probe that binds to carcinoembryonic antigen, expressed on colorectal cancer cells, and describe the results of their phase I clinical
Externí odkaz:
https://doaj.org/article/88e964c101f84c1c99ce8e827c6c5f1d
Autor:
Phyllis F. Cheung, JiaJin Yang, Rui Fang, Arianna Borgers, Kirsten Krengel, Anne Stoffel, Kristina Althoff, Chi Wai Yip, Elaine H. L. Siu, Linda W. C. Ng, Karl S. Lang, Lamin B. Cham, Daniel R. Engel, Camille Soun, Igor Cima, Björn Scheffler, Jana K. Striefler, Marianne Sinn, Marcus Bahra, Uwe Pelzer, Helmut Oettle, Peter Markus, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Konstantinos Savvatakis, Sven-Thorsten Liffers, Smiths S. Lueong, Christian Neander, Anna Bazarna, Xin Zhang, Annette Paschen, Howard C. Crawford, Anthony W. H. Chan, Siu Tim Cheung, Jens T. Siveke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation o
Externí odkaz:
https://doaj.org/article/c9aa189db2194c2eba13f30f461a6fdd
Autor:
Erik H. J. G. Aarntzen, Edel Noriega-Álvarez, Vera Artiko, André H. Dias, Olivier Gheysens, Andor W. J. M. Glaudemans, Chiara Lauri, Giorgio Treglia, Tim van den Wyngaert, Fijs W. B. van Leeuwen, Samantha Y. A. Terry
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and adaptive immune responses. Unde
Externí odkaz:
https://doaj.org/article/8d66abcd47cd4ca5a35470f7dcf71d70
Autor:
Esther M. M. Smeets, Daphne N. Dorst, Gerben M. Franssen, Merijn S. van Essen, Cathelijne Frielink, Martijn W. J. Stommel, Marija Trajkovic-Arsic, Phyllis F. Cheung, Jens T. Siveke, Ian Wilson, Alessandro Mascioni, Erik H. J. G. Aarntzen, Sanne A. M. van Lith
Publikováno v:
Cells, Vol 12, Iss 10, p 1420 (2023)
Fibroblast activation protein (FAP), expressed on cancer-associated fibroblasts, is a target for diagnosis and therapy in multiple tumour types. Strategies to systemically deplete FAP-expressing cells show efficacy; however, these induce toxicities,
Externí odkaz:
https://doaj.org/article/6aff23dd68ac4fd7aa278e29c1b723ca
Autor:
Gerwin G. W. Sandker, Gosse Adema, Janneke Molkenboer-Kuenen, Peter Wierstra, Johan Bussink, Sandra Heskamp, Erik H. J. G. Aarntzen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundProgrammed death-ligand 1 (PD-L1) regulates immune homeostasis by promoting T-cell exhaustion. It is involved in chronic infections and tumor progression. Nuclear imaging using radiolabeled anti-PD-L1 antibodies can monitor PD-L1 tissue exp
Externí odkaz:
https://doaj.org/article/785887c64a7e45628531f9d9e709f550
Autor:
Evelien A. J. van Genugten, Jetty A. M. Weijers, Sandra Heskamp, Manfred Kneilling, Michel M. van den Heuvel, Berber Piet, Johan Bussink, Lizza E. L. Hendriks, Erik H. J. G. Aarntzen
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Metabolic reprogramming is recognized as one of the hallmarks of cancer. Alterations in the micro-environmental metabolic characteristics are recognized as important tools for cancer cells to interact with the resident and infiltrating T-cells within
Externí odkaz:
https://doaj.org/article/9b66e4df3d91464b8a3b133634adb7fa