Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Erik H. Heijne"'
Autor:
Erik H. Heijne, Christopher D. Hupp, John W. Cuozzo, Anthony D. Keefe, Rob Winkel, L. Babiss, Wendy van Bruggen, Louis Renzetti, Mark J. Mulvihill, Birgit Zech, Andrew J. McRiner, Johan J. N. Veerman, Eddy Damen, Yorik B. Bruseker, Heather A. Thomson, Julie Liu, Gerhard Müller, Koen F. W. Hekking, Ying Zhang, Peter van Rijnsbergen
Publikováno v:
ACS Medicinal Chemistry Letters. 12:555-562
Herein we report the discovery of 2,4-1H-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a DNA-encoded chemical library (DE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d65527e5f7e8fb6d40ba9c6dda27029
https://doi.org/10.1021/acsmedchemlett.0c00547
https://doi.org/10.1021/acsmedchemlett.0c00547
Autor:
Johan J N, Veerman, Yorik B, Bruseker, Eddy, Damen, Erik H, Heijne, Wendy, van Bruggen, Koen F W, Hekking, Rob, Winkel, Christopher D, Hupp, Anthony D, Keefe, Julie, Liu, Heather A, Thomson, Ying, Zhang, John W, Cuozzo, Andrew J, McRiner, Mark J, Mulvihill, Peter, van Rijnsbergen, Birgit, Zech, Louis M, Renzetti, Lee, Babiss, Gerhard, Müller
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein we report the discovery of 2,4-1H-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a DNA-encoded ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12d9ec47ec0b7cafcb9e7a681001f5ae
https://pubmed.ncbi.nlm.nih.gov/33859795
https://pubmed.ncbi.nlm.nih.gov/33859795
Publikováno v:
Tetrahedron Letters. 39:3295-3298
5-Amino- endo -tricyclo[5.2.1.0 2,6 ]deca-4,8-dien-3-ones 4 undergo a surprisingly effective regioselective halogenation using N-halosuccinimides (NXS) under electrophilic conditions. Exclusive α-halogenation is observed using one equiv. of NXS, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d3fe3f9a903db3db312ab648784e9b
https://doi.org/10.1016/s0040-4039(98)00474-2
https://doi.org/10.1016/s0040-4039(98)00474-2
Autor:
Erik H. Heijne, Peter van Rijnsbergen, Wim Zonneveld, Johan J. N. Veerman, Bryce Alden Harrison, T.M. Meulemans, Rebecca Glen, Bart C. J. van Esseveldt, Yorik B. Bruseker, Duane A. Burnett, Matthew Gregory Bursavich, Andrew J. McRiner
Publikováno v:
HETEROCYCLES. 92:2166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37d75a7f11ad38458a8a12cc2b045acc
https://doi.org/10.3987/com-16-13570
https://doi.org/10.3987/com-16-13570
Publikováno v:
ChemInform. 29
5-Amino- endo -tricyclo[5.2.1.0 2,6 ]deca-4,8-dien-3-ones 4 undergo a surprisingly effective regioselective halogenation using N-halosuccinimides (NXS) under electrophilic conditions. Exclusive α-halogenation is observed using one equiv. of NXS, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b53d66be61582c8ed45e8724ad9750f
https://doi.org/10.1002/chin.199832132
https://doi.org/10.1002/chin.199832132
Publikováno v:
ChemInform. 33
An effective regioselective halogenation of 5-amino-endo-tricyclo decenyl enaminones 6 using N-halosuccinimides is reported. The reaction is extremely fast and the yields are almost quantitative. Exclusive α,N-dihalo or α,γ-dihalo compounds can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bae1fdb5ad8e828bc7ba741c018be861
https://doi.org/10.1002/chin.200229134
https://doi.org/10.1002/chin.200229134
Autor:
Giovanni Gottarelli, Silvia Pieraccini, Stefano Masiero, Vincenza Andrisano, Erik H. Heijne, Gian Piero Spada
Publikováno v:
Angewandte Chemie International Edition. 38:2386-2388
The transfer of potassium salts of dinitrophenyl amino acids from water to chloroform by the lipophilic guanosine derivative 1 takes place enantioselectively. Depending on the K(+):1 ratio, G-quartets of 1 self-assemble into octamers (O) or polymers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f372fa5aea857cad18a7c872995eff81
https://doi.org/10.1002/(sici)1521-3773(19990816)38:16<2386::aid-anie2386>3.0.co
https://doi.org/10.1002/(sici)1521-3773(19990816)38:16<2386::aid-anie2386>3.0.co
Autor:
Giovanni Gottarelli, Vicenza Andrisano, Erik H. Heijne, Silvia Pieraccini, Stefano Masiero, Gian Piero Spada
Publikováno v:
Angewandte Chemie. 111:2543-2544
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b92ed79b260aa547ef2bd4ca7f39b88
https://doi.org/10.1002/(sici)1521-3757(19990816)111:16<2543::aid-ange2543>3.0.co
https://doi.org/10.1002/(sici)1521-3757(19990816)111:16<2543::aid-ange2543>3.0.co