Prognostic Significance of Integrin Subunit Alpha 2 (ITGA2) and Role of Mechanical Cues in Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma (PDAC)

Autor: Alessandro Gregori, Cecilia Bergonzini, Mjriam Capula, Giulia Mantini, Fatemeh Khojasteh-Leylakoohi, Annalisa Comandatore, Ghazaleh Khalili-Tanha, Alireza Khooei, Luca Morelli, Amir Avan, Erik H. Danen, Thomas Schmidt, Elisa Giovannetti

Publikováno v: Cancers
Volume 15
Issue 3
Pages: 628
Cancers, 15(3):628. MDPI AG
Cancers, 15(3):628. Multidisciplinary Digital Publishing Institute (MDPI)
Gregori, A, Bergonzini, C, Capula, M, Mantini, G, Khojasteh-Leylakoohi, F, Comandatore, A, Khalili-Tanha, G, Khooei, A, Morelli, L, Avan, A, Danen, E H, Schmidt, T & Giovannetti, E 2023, ' Prognostic Significance of Integrin Subunit Alpha 2 (ITGA2) and Role of Mechanical Cues in Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma (PDAC) ', Cancers, vol. 15, no. 3, 628 . https://doi.org/10.3390/cancers15030628

Introduction: PDAC is an extremely aggressive tumor with a poor prognosis and remarkable therapeutic resistance. The dense extracellular matrix (ECM) which characterizes PDAC progression is considered a fundamental determinant of chemoresistance, wit

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