Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Erik H J Danen"'
Autor:
Chen-Yi Liao, Patrick Engelberts, Andreea Ioan-Facsinay, Janna Eleonora Klip, Thomas Schmidt, Rob Ruijtenbeek, Erik H. J. Danen
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The mechanism of action of bispecific antibodies (bsAbs) directing T-cell immunity to solid tumors is incompletely understood. Here, we screened a series of CD3xHER2 bsAbs using extracellular matrix (ECM) embedded breast cancer tumoroid arra
Externí odkaz:
https://doaj.org/article/3dbee69a51ca4c49b03f87873fef6082
Autor:
Cecilia Bergonzini, Alessandro Gregori, Tessa M. S. Hagens, Vera E. van der Noord, Bob van de Water, Annelien J. M. Zweemer, Bircan Coban, Mjriam Capula, Giulia Mantini, Asia Botto, Francesco Finamore, Ingrid Garajova, Liam A. McDonnell, Thomas Schmidt, Elisa Giovannetti, Erik H. J. Danen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer and the chemotherapies such as gemcitabine/nab-paclitaxel are confronted with intrinsic or acquired resistance. The aim of this study was to investiga
Externí odkaz:
https://doaj.org/article/178d9e5136a64abeb42daf0ec279d03d
Autor:
Veerander P S Ghotra, Shuning He, Hans de Bont, Wietske van der Ent, Herman P Spaink, Bob van de Water, B Ewa Snaar-Jagalska, Erik H J Danen
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31281 (2012)
A quantitative bio-imaging platform is developed for analysis of human cancer dissemination in a short-term vertebrate xenotransplantation assay. Six days after implantation of cancer cells in zebrafish embryos, automated imaging in 96 well plates co
Externí odkaz:
https://doaj.org/article/98586dadc5d548bd80b730a293942246
Autor:
Zi Wang, Bircan Coban, Haoyu Wu, Jihed Chouaref, Lucia Daxinger, Michelle T. Paulsen, Mats Ljungman, Marcel Smid, John W. M. Martens, Erik H. J. Danen
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Grainyhead like 2 (GRHL2) is an essential transcription factor for development and function of epithelial tissues. It has dual roles in cancer by supporting tumor growth while suppressing epithelial to mesenchymal transitions (EMT). GRHL2 co
Externí odkaz:
https://doaj.org/article/66354d7f23a046039396b5df2989ebe4
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2512 (2023)
The transcription factor Grainyhead-like 2 (GRHL2) is a critical transcription factor for epithelial tissues that has been reported to promote cancer growth in some and suppress aspects of cancer progression in other studies. We investigated its role
Externí odkaz:
https://doaj.org/article/74af63da32b2428cb7939651f34f2e5b
Autor:
Qiuyu Liu, Wanda van der Stel, Vera E. van der Noord, Hanneke Leegwater, Bircan Coban, Kim Elbertse, Joannes T. M. Pruijs, Olivier J. M. Béquignon, Gerard van Westen, Sylvia E. Le Dévédec, Erik H. J. Danen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10119 (2022)
Hypoxia and HIF signaling drive cancer progression and therapy resistance and have been demonstrated in breast cancer. To what extent breast cancer subtypes differ in their response to hypoxia has not been resolved. Here, we show that hypoxia similar
Externí odkaz:
https://doaj.org/article/25e72d3113694ba0b44f841b00a020df
Autor:
Huan Yang, Wanda van der Stel, Randy Lee, Caroline Bauch, Sam Bevan, Paul Walker, Bob van de Water, Erik H. J. Danen, Joost B. Beltman
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Mitochondria are the main bioenergetic organelles of cells. Exposure to chemicals targeting mitochondria therefore generally results in the development of toxicity. The cellular response to perturbations in cellular energy production is a balance bet
Externí odkaz:
https://doaj.org/article/fee3a32d499742bb887a718282353d47
Autor:
Qiuyu Liu, Nasi Liu, Vera van der Noord, Wanda van der Stel, Bob van de Water, Erik H. J. Danen, Sylvia E. Le Dévédec
Publikováno v:
Breast Cancer Research and Treatment, 198, 583-596
Hypoxia is linked to disease progression and poor prognosis in several cancers, including breast cancer. Cancer cells can encounter acute, chronic, and/or intermittent periods of oxygen deprivation and it is poorly understood how the different breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479d0f6c32ad5b468464fb698986b6ed
https://hdl.handle.net/1887/3590025
https://hdl.handle.net/1887/3590025
Autor:
Chenlin Feng, Xuesong Wang, Willem Jespers, Rongfang Liu, Sofía Denise Zamarbide Losada, Marina Gorostiola González, Gerard J. P. van Westen, Erik H. J. Danen, Laura H. Heitman
Publikováno v:
Molecules; Volume 27; Issue 15; Pages: 4676
Molecules, 27(15):4676. MDPI
Molecules, 27(15):4676. MDPI
The adenosine A2A receptor (A2AAR) is a class A G-protein-coupled receptor (GPCR). It is an immune checkpoint in the tumor micro-environment and has become an emerging target for cancer treatment. In this study, we aimed to explore the effects of can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27cb45a4004a1186b99ba54635eee7b
https://doi.org/10.3390/molecules27154676
https://doi.org/10.3390/molecules27154676
Autor:
Chenlin, Feng, Xuesong, Wang, Willem, Jespers, Rongfang, Liu, Sofía Denise, Zamarbide Losada, Marina, Gorostiola González, Gerard J P, van Westen, Erik H J, Danen, Laura H, Heitman
Publikováno v:
Molecules (Basel, Switzerland). 27(15)
The adenosine A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2cb12aeadf90b8c0538f50755e4682c3
https://pubmed.ncbi.nlm.nih.gov/35897852
https://pubmed.ncbi.nlm.nih.gov/35897852