Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Erik Guetschow"'
Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib
Autor:
Yonggang Chen, Luca Iuzzolino, Samantha A. Burgess, Cheol K. Chung, James Corry, Morgan Crawford, Richard Desmond, Erik Guetschow, Clara Hartmanshenn, Nadine Kuhl, Zhu Liu, Hanlin Luo, Alison C. McQuilken, Justin A. Newman, Hong Ren, David A. Thaisrivongs, Zhixun Wang, Eric Sirota
Publikováno v:
Organic Process Research & Development. 27:659-668
Autor:
Nadine Kuhl, Ben W. H. Turnbull, Yining Ji, Reed T. Larson, Michael Shevlin, Christopher K. Prier, Cheol K. Chung, Richard Desmond, Erik Guetschow, Cyndi Qixin He, Tetsuji Itoh, Jeffrey T. Kuethe, Justin A. Newman, Mikhail Reibarkh, Nelo R. Rivera, Gao Shang, Zhixun Wang, Daniel Zewge, David A. Thaisrivongs
Publikováno v:
Green Chemistry. 25:606-613
The development of a protecting group-free, 2-step synthesis of 5-amino-2-hydroxymethyltetrahydropyran 1a from biorenewable Cyrene™ is described which renders access to BTK-inhibitor nemtabrutinib (2) more efficient and sustainable.
Autor:
Fengqiang Wang, Xuanwen Li, Michael Swanson, Erik Guetschow, Matthew Winston, Joseph P. Smith, Erik Hoyt, Zhijian Liu, Douglas Richardson, Xiaodong Bu, Vibha Jawa, Narayan Variankaval
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 119(8)
Host cell proteins (HCPs) are a significant class of process-related impurities commonly associated with the manufacturing of biopharmaceuticals. However, due to the increased use of crude enzymes as biocatalysts for modern organic synthesis, HCPs ca
Autor:
Fengqiang Wang, Xuanwen LI, Michael Swanson, Erik Guetschow, Matthew Winston, Joseph P. Smith, Erik Hoyt, Zhijian Liu, Douglas Richardson, Xiaodong Bu, Vibha Jawa, Narayan Variankaval
Host cell proteins (HCPs) are a significant class of process-related impurities commonly associated with the manufacturing of biopharmaceuticals. However, due to the increased use of crude enzymes as biocatalysts for modern organic synthesis, HCPs ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8daf0e50b63fc6b14bcd56d4cca31b5
https://doi.org/10.22541/au.164357154.47616615/v1
https://doi.org/10.22541/au.164357154.47616615/v1
Autor:
John A. McIntosh, Zhijian Liu, Brian M. Andresen, Nastaran Salehi Marzijarani, Jeffrey C. Moore, Nicholas M. Marshall, Margie Borra-Garske, Jennifer V. Obligacion, Patrick S. Fier, Feng Peng, Jacob H. Forstater, Matthew S. Winston, Chihui An, Wonsuk Chang, Jongwon Lim, Mark A. Huffman, Steven P. Miller, Fuh-Rong Tsay, Michael D. Altman, Charles A. Lesburg, Dietrich Steinhuebel, B. Wesley Trotter, Jared N. Cumming, Alan Northrup, Xiaodong Bu, Benjamin F. Mann, Mirlinda Biba, Kaori Hiraga, Grant S. Murphy, Joshua N. Kolev, Amanda Makarewicz, Weilan Pan, Iman Farasat, Rachel S. Bade, Kevin Stone, Da Duan, Oscar Alvizo, Donovan Adpressa, Erik Guetschow, Erik Hoyt, Erik L. Regalado, Steve Castro, Nelo Rivera, Joseph P. Smith, Fengqiang Wang, Alejandro Crespo, Deeptak Verma, Stephanus Axnanda, Zachary E. X. Dance, Paul N. Devine, David Tschaen, Keith A. Canada, Paul G. Bulger, Benjamin D. Sherry, Matthew D. Truppo, Rebecca T. Ruck, Louis-Charles Campeau, David Jonathan Bennett, Guy R. Humphrey, Kevin R. Campos, Matthew L. Maddess
Publikováno v:
Nature. 603(7901)
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this challenge by using enzymes to carry out multi