Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Erik Funder"'
Autor:
Jörg Duschmalé, Adrian Schäublin, Erik Funder, Steffen Schmidt, Łukasz J. Kiełpiński, Helle Nymark, Klaus Jensen, Troels Koch, Martina Duschmalé, Erich Koller, Marianne Ravn Møller, Simone Schadt, Christophe Husser, Andreas Brink, Sabine Sewing, Tanja Minz, Jesper Wengel, Konrad Bleicher, Meiling Li
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 176-188 (2022)
The introduction of sulfur into the phosphate linkage of chemically synthesized oligonucleotides creates the stereocenters on phosphorus atoms. Researchers have valued the nature of backbone stereochemistry and early on investigated drug properties f
Externí odkaz:
https://doaj.org/article/129e910e0f0444d193c51f62a0777c79
Publikováno v:
Nucleic Acid Therapeutics. 31:383-391
Phosphorothioate (PS) modification of antisense oligonucleotides (ASOs) is a critical factor enabling their therapeutic use. Standard chemical synthesis incorporates this group in a stereorandom ma...
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0232603 (2020)
PLoS ONE, Vol 15, Iss 6, p e0232603 (2020)
Drug discovery with phosphorothioate oligonucleotides is an area of intensive research. In this study we have controlled the stereochemistry of the phosphorothioate backbone of LNA oligonucleotides to investigate the differences in safety profile, ta
Autor:
Henrik Frydenlund Hansen, Marianne R. Møller, Peter Hagedorn, Dennis Jul Hansen, Mads Jensen, Erik Funder, Nanna Albæk, Helle Christiansen, Natalia Papargyri, Sanna L. Diemer, Troels Koch, Robert Persson, Bo Hansen
Publikováno v:
Hagedorn, P H, Persson, R, Funder, E D, Albæk, N, Diemer, S L, Hansen, D J, Møller, M R, Papargyri, N, Christiansen, H, Hansen, B R, Hansen, H F, Jensen, M A & Koch, T 2018, ' Locked nucleic acid: modality, diversity, and drug discovery ', Drug Discovery Today, vol. 23, no. 1, pp. 101-114 . https://doi.org/10.1016/j.drudis.2017.09.018
Over the past 20 years, the field of RNA-targeted therapeutics has advanced based on discoveries of modified oligonucleotide chemistries, and an ever-increasing understanding of how to apply cellular assays to identify oligonucleotides with improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e87e530133cecf9154e084346d5c3e2
https://orbit.dtu.dk/en/publications/b710204c-53b5-4d78-bbbb-8771e480792b
https://orbit.dtu.dk/en/publications/b710204c-53b5-4d78-bbbb-8771e480792b
Autor:
Duschmalé, Jörg, Hansen, Henrik Frydenlund, Duschmalé, Martina, Koller, Erich, Albaek, Nanna, Møller, Marianne Ravn, Jensen, Klaus, Koch, Troels, Wengel, Jesper, Bleicher, Konrad
Publikováno v:
Nucleic Acids Research; 1/10/2020, Vol. 48 Issue 1, p63-74, 12p