Passivated Impedimetric Sensors for Immobilization-Free Pathogen Detection by Isothermal Amplification and Melt Curve Analysis

Autor: Matthias Steinmaßl, Jamila Boudaden, Güven Edgü, Lena Julie Freund, Simon Meyer, Noa Mordehay, Melissa Soto, Hanns-Erik Endres, Jost Muth, Dirk Prüfer, Wilfried Lerch, Christoph Kutter

Publikováno v: Biosensors, Vol 12, Iss 5, p 261 (2022)

The ongoing SARS-CoV-2 pandemic demonstrates that the capacity of centralized clinical diagnosis laboratories represents a significant limiting factor in the global fight against the newly emerged virus. Scaling up these capacities also requires simp

Externí odkaz: https://doaj.org/article/e27c45618a0b4395ba0cb84742b8c078

Towards Low Cost and Low Temperature Capacitive CO2 Sensors Based on Amine Functionalized Silica Nanoparticles

Autor: Jamila Boudaden, Armin Klumpp, Hanns-Erik Endres, Ignaz Eisele

Publikováno v: Nanomaterials, Vol 9, Iss 8, p 1097 (2019)

Hybrid materials based on inorganic particles and an organic polymer were developed and used as an efficient sensing material for carbon dioxide (CO2). The sensing material consists of fumed silica that is functionalized with an organic polymer, poly

Externí odkaz: https://doaj.org/article/a45bc0e4453c44d9b9ed3e1c7c72331e

Polyimide-Based Capacitive Humidity Sensor

Autor: Jamila Boudaden, Matthias Steinmaßl, Hanns-Erik Endres, Andreas Drost, Ignaz Eisele, Christoph Kutter, Peter Müller-Buschbaum

Publikováno v: Sensors, Vol 18, Iss 5, p 1516 (2018)

The development of humidity sensors with simple transduction principles attracts considerable interest by both scientific researchers and industrial companies. Capacitive humidity sensors, based on polyimide sensing material with different thickness

Externí odkaz: https://doaj.org/article/726c830491bb408a820462bdc457d245

Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain

Autor: Tanja Schirmeister, Sascha Jung, Collin Zimmer, Carsten Sönnichsen, Weixiang Ye, Christoph A. Sotriffer, Hannes Neuweiler, Christian Kersten, Ute A. Hellmich, Patrick Johe, Erik Endres

Publikováno v: ACS chemical biology. 16(4)

Viral and parasitic pathogens rely critically on cysteine proteases for host invasion, replication, and infectivity. Their inhibition by synthetic inhibitors, such as vinyl sulfone compounds, has emerged as a promising treatment strategy. However, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0709448253d15c051ccef3d5a3966bd
https://pubmed.ncbi.nlm.nih.gov/33719398

Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model

Autor: Sandra Gunesch, Erik Endres, Carina Stiller, Michael Decker, Matthias Hoffmann, Tangui Maurice, Matthias Scheiner, Christoph A. Sotriffer

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (20), pp.9116-9140. ⟨10.1021/acs.jmedchem.9b01012⟩

In this study, the carbamate structure of pseudo-irreversible butyrylcholinesterase (BChE) inhibitors was optimized with regard to a longer binding to the enzyme. A set of compounds bearing different heterocycles (e.g., morpholine, tetrahydroisoquino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205747c4c766f3b32351b9b59c1f540d
https://pubmed.ncbi.nlm.nih.gov/31609115