Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Erik E. Karrer"'
Autor:
Fujiko Takamura, Erik E. Karrer, Yasuyuki Higashi, Steven J. Chapin, Margaret Neighbors, Sridhar Viswanathan, Hidekazu Mizuhara, Shinsuke Oshima, Yasutomo Fujii, Bruce H. Devens
Publikováno v:
International Immunopharmacology. 40:310-317
The CTLA4-Ig fusion proteins abatacept and belatacept inhibit CD28-mediated T cell activation by binding CD80 (B7-1) and CD86 (B7-2) costimulatory ligands and are clinically proven immunosuppressants used for rheumatoid arthritis and renal transplant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ff00ad001bd419bd264871d2b736f8
https://doi.org/10.1016/j.intimp.2016.09.009
https://doi.org/10.1016/j.intimp.2016.09.009
Autor:
Vicki Santos, James Keirns, Leticia Delgado-Herrera, Ronald Goldwater, Bernhardt Zeiher, Erik E. Karrer, Vishala Chindalore, Atsunori Kaibara, Alan Kivitz, Paul Blahunka, Tong Zhu, Corrie Howieson, Nancy L. Samberg, Stanley Cohen, Robert M. Kernstock, Bolanle Akinlade, Jay P. Garg
Publikováno v:
Clinical Pharmacology in Drug Development. 5:408-425
ASP2408 is a next-generation anti-cytotoxic T lymphocyte antigen-4 fusion protein engineered for improved CD86 binding affinity as a treatment for rheumatoid arthritis (RA). In 72 healthy subjects (n = 6/treatment), ASP2408 was administered as single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd897b1f9a2f3b39f08ba27c83db348
https://doi.org/10.1002/cpdd.251
https://doi.org/10.1002/cpdd.251
Autor:
Kuoting Wu, Clifford Wong, Margaret Neighbors, Erik E. Karrer, Yasuyuki Higashi, Madan M. Paidhungat, Steven J. Chapin, Steven H. Bass, Bruce H. Devens, Shinsuke Oshima, Margaret Reed, Brent R. Larsen, Yonghong Chen, Francisco A. Anderson, Marc Whitlow, Rujuta A. Bam, Sridhar Viswanathan, Rong A. Fan, Qian Zhang
Publikováno v:
Protein Engineering Design and Selection. 29:159-167
The CTLA4-Ig therapeutics abatacept and belatacept inhibit CD28-mediated T cell activation by binding CD80 (B7-1) and CD86 (B7-2) co-stimulatory ligands. Both compounds preferentially bind CD80, yet CD86 has been implicated as the dominant co-stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16578a205d00bb45328a4431b02b5c0
https://doi.org/10.1093/protein/gzw002
https://doi.org/10.1093/protein/gzw002
Autor:
Bernhardt Zeiher, Stanley Cohen, Leticia Delgado-Herrera, Nancy L. Samberg, Erik E. Karrer, Alan Kivitz, Jay P. Garg, Vishala Chindalore, Paul Blahunka, Robert M. Kernstock, Wenhui Zhang
Publikováno v:
Clinical Pharmacology in Drug Development. 5:259-268
ASP2409 represents a new class of CTLA4-Ig molecules with higher binding avidity and selectivity to CD86. This first-in-human study was to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of ASP2409 in stable rheumatoid ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bf941d6c7bb86b0fd8095d07979fb5
https://doi.org/10.1002/cpdd.237
https://doi.org/10.1002/cpdd.237
Autor:
M. Song, Steven J. Chapin, Denise Lo, Frank V. Leopardi, Allan D. Kirk, Erik E. Karrer, Bruce H. Devens, Elizabeth Strobert, Douglas J. Anderson, Alton B. Farris
Publikováno v:
American Journal of Transplantation. 15:984-992
Costimulation blockade with the B7-CD28 pathway-specific agent belatacept is now used in clinical kidney transplantation, but its efficacy remains imperfect. Numerous alternate costimulatory pathways have been proposed as targets to synergize with be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecba3c405492bc31bde3f4a6ae175b2d
https://doi.org/10.1111/ajt.13100
https://doi.org/10.1111/ajt.13100
Autor:
Yasutomo Fujii, Takahisa Noto, Yasuyuki Higashi, Steven J. Chapin, Margaret Neighbors, Yuka Kawato, Shinsuke Oshima, B. Devens, Masashi Maeda, Sridhar Viswanathan, Susumu Tsujimoto, Jun Hirose, Hidehiko Fukahori, Fujiko Takamura, Erik E. Karrer, Koji Nakamura, Takanori Marui
Publikováno v:
Transplantation. 100(12)
Background Blockade of CD28-mediated T cell costimulation by a modified cytotoxic T lymphocyte-associated antigen 4 (CTLA4-Ig), belatacept, is a clinically effective immunosuppressive therapy for the prevention of renal allograft rejection. Use of be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fd00138a6907188d0b97a98d07cdb8
https://pubmed.ncbi.nlm.nih.gov/27861289
https://pubmed.ncbi.nlm.nih.gov/27861289
Publikováno v:
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents. 2:228-236
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d62bece0ef0c46378a25c2b6fd158dbf
https://doi.org/10.2174/1568014033483716
https://doi.org/10.2174/1568014033483716
Publikováno v:
Journal of Molecular Biology. 290:9-20
The biophysical properties of the tobacco mosaic tobamovirus (TMV) coat protein (CP) make it possible to display foreign peptides on the surface of TMV. The immunogenic epitopes G5-24 from the rabies virus (RV) glycoprotein, and 5B19 from murine hepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7490c85a608d8f3af719911f1d32c719
https://doi.org/10.1006/jmbi.1999.2860
https://doi.org/10.1006/jmbi.1999.2860
Publikováno v:
Plant Molecular Biology. 36:681-690
We used a functional screening method to isolate genes whose products elicit the hypersensitive response (HR) pathway of defense against plant pathogens. A cDNA library derived from tobacco leaves undergoing the HR was cloned into a tobacco mosaic vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d47c78a5b4b5e82c7c4f8bd4151133
https://doi.org/10.1023/a:1005949304445
https://doi.org/10.1023/a:1005949304445
Publikováno v:
Plant Molecular Biology. 36:331-341
Expression of alpha-amylase genes during seedling development plays a key role in production of sugar from the starch stored in the cereal seed. Rice alpha-amylase Amy3D promoter/GUS constructs in transgenic rice cell lines were studied to identify c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d569248b0e8cadc55501f9e52d207ad3
https://doi.org/10.1023/a:1005956104636
https://doi.org/10.1023/a:1005956104636