Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Erik Duijvelaar"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The pathobiology of respiratory failure in COVID-19 consists of a complex interplay between viral cytopathic effects and a dysregulated host immune response. In critically ill patients, imatinib treatment demonstrated potential for reducing
Externí odkaz:
https://doaj.org/article/d4625774177b4d73a50bde08a7c3c3f8
Autor:
Leila N. Atmowihardjo, Job R. Schippers, Erik Duijvelaar, Imke H. Bartelink, Pierre M. Bet, Noortje E. L. Swart, Nienke van Rein, Keith Purdy, David Cavalla, Andrew McElroy, Sarah Fritchley, Anton Vonk Noordegraaf, Henrik Endeman, Patricia van Velzen, Matty Koopmans, Harm Jan Bogaard, Leo Heunks, Nicole Juffermans, Marcus J. Schultz, Pieter R. Tuinman, Lieuwe D. J. Bos, Jurjan Aman
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-13 (2023)
Abstract Purpose A hallmark of acute respiratory distress syndrome (ARDS) is hypoxaemic respiratory failure due to pulmonary vascular hyperpermeability. The tyrosine kinase inhibitor imatinib reversed pulmonary capillary leak in preclinical studies a
Externí odkaz:
https://doaj.org/article/9b66fd0c759d40f6b53c6782c1837294
Autor:
Imke H. Bartelink, Pierre M. Bet, Nicolas Widmer, Monia Guidi, Erik Duijvelaar, Bram Grob, Richard Honeywell, Amanda Evelo, Ivo P. E. Tielbeek, Sue D. Snape, Henrike Hamer, Laurent A. Decosterd, Harm Jan Bogaard, Jurjan Aman, Eleonora L. Swart
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 12, Pp 1497-1511 (2021)
Abstract This study aimed to determine whether published pharmacokinetic (PK) models can adequately predict the PK profile of imatinib in a new indication, such as coronavirus disease 2019 (COVID‐19). Total (bound + unbound) and unbound imatinib pl
Externí odkaz:
https://doaj.org/article/84259887a4a245ea94b698c03f036179
Autor:
Nadia Baalbaki, Erik Duijvelaar, Medhat M. Said, Job Schippers, Pierre M. Bet, Jos Twisk, Sarah Fritchley, Cristina Longo, Kazien Mahmoud, Anke H. Maitland-van der Zee, Harm Jan Bogaard, Eleonora L. Swart, Jurjan Aman, Imke H. Bartelink
Publikováno v:
Baalbaki, N, Duijvelaar, E, Said, M M, Schippers, J, Bet, P M, Twisk, J, Fritchley, S, Longo, C, Mahmoud, K, Maitland-van der Zee, A H, Bogaard, H J, Swart, E L, Aman, J & Bartelink, I H 2023, ' Pharmacokinetics and pharmacodynamics of imatinib for optimal drug repurposing from cancer to COVID-19 ', European Journal of Pharmaceutical Sciences, vol. 184, 106418 . https://doi.org/10.1016/j.ejps.2023.106418
European Journal of Pharmaceutical Sciences, 184:106418. Elsevier
European Journal of Pharmaceutical Sciences, 184:106418. Elsevier
Introduction: In the randomized double-blind placebo-controlled CounterCOVID study, oral imatinib treatment conferred a positive clinical outcome and a signal for reduced mortality in COVID-19 patients. High concentrations of alpha-1 acid glycoprotei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ca77a4480a98326896ab48f4b0e96e
https://research.vumc.nl/en/publications/269bef74-d9b2-46e0-b8b4-50fa6d0d2bc8
https://research.vumc.nl/en/publications/269bef74-d9b2-46e0-b8b4-50fa6d0d2bc8
Autor:
Justin de Brabander, Erik Duijvelaar, Job R. Schippers, Patrick J. Smeele, Hessel Peters-Sengers, Jan Willem Duitman, Jurjan Aman, Harm Jan Bogaard, Tom van der Poll, Lieuwe D.J. Bos
Publikováno v:
European respiratory journal, 60(6):2200780. European Respiratory Society
CounterCOVID study group 2022, ' Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients ', The European respiratory journal, vol. 60, no. 6, 2200780 . https://doi.org/10.1183/13993003.00780-2022
European Respiratory Journal
The European respiratory journal, 60(6):2200780. European Respiratory Society
The European respiratory journal, 60(6). European Respiratory Society
European Respiratory Journal, 60(6):2200780. European Respiratory Society
CounterCOVID study group 2022, ' Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients ', The European respiratory journal, vol. 60, no. 6, 2200780 . https://doi.org/10.1183/13993003.00780-2022
European Respiratory Journal
The European respiratory journal, 60(6):2200780. European Respiratory Society
The European respiratory journal, 60(6). European Respiratory Society
European Respiratory Journal, 60(6):2200780. European Respiratory Society
BackgroundImatinib reduced 90-day mortality in hospitalised coronavirus disease 2019 (COVID-19) patients in a recent clinical trial, but the biological effects that cause improved clinical outcomes are unknown. We aimed to determine the biological ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521e422c5446a6bd8340ac7bff18ea92
https://pure.amc.nl/en/publications/immunomodulation-and-endothelial-barrier-protection-mediate-the-association-between-oral-imatinib-and-mortality-in-hospitalised-covid19-patients(461024c8-4bed-40b7-b1cc-633fd3e72a1b).html
https://pure.amc.nl/en/publications/immunomodulation-and-endothelial-barrier-protection-mediate-the-association-between-oral-imatinib-and-mortality-in-hospitalised-covid19-patients(461024c8-4bed-40b7-b1cc-633fd3e72a1b).html
Autor:
Ivo P E Tielbeek, Richard Honeywell, Bram Grob, Pierre M Bet, Harm Jan Bogaard, Monia Guidi, Erik Duijvelaar, Imke H Bartelink, Eleonora L Swart, Nicolas Widmer, Laurent A. Decosterd, Jurjan Aman, Amanda Evelo, Sue D Snape, Henrike Hamer
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT, vol. 10, no. 12, pp. 1497-1511
Bartelink, I H, Bet, P M, Widmer, N, Guidi, M, Duijvelaar, E, Grob, B, Honeywell, R, Evelo, A, Tielbeek, I P E, Snape, S D, Hamer, H, Decosterd, L A, Bogaard, H J, Aman, J & Swart, E L 2021, ' Elevated acute phase proteins affect pharmacokinetics in COVID-19 trials : lessons from the CounterCovid-imatinib-study ', CPT: Pharmacometrics and Systems Pharmacology, vol. 10, no. 12, pp. 1497-1511 . https://doi.org/10.1002/psp4.12718
CPT: Pharmacometrics and Systems Pharmacology, 10(12), 1497-1511. Wiley-Blackwell
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 12, Pp 1497-1511 (2021)
CPT, vol. 10, no. 12, pp. 1497-1511
Bartelink, I H, Bet, P M, Widmer, N, Guidi, M, Duijvelaar, E, Grob, B, Honeywell, R, Evelo, A, Tielbeek, I P E, Snape, S D, Hamer, H, Decosterd, L A, Bogaard, H J, Aman, J & Swart, E L 2021, ' Elevated acute phase proteins affect pharmacokinetics in COVID-19 trials : lessons from the CounterCovid-imatinib-study ', CPT: Pharmacometrics and Systems Pharmacology, vol. 10, no. 12, pp. 1497-1511 . https://doi.org/10.1002/psp4.12718
CPT: Pharmacometrics and Systems Pharmacology, 10(12), 1497-1511. Wiley-Blackwell
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 12, Pp 1497-1511 (2021)
This study aimed to determine whether published pharmacokinetic (PK) models can adequately predict the PK profile of imatinib in a new indication, such as coronavirus disease 2019 (COVID-19). Total (bound + unbound) and unbound imatinib plasma concen
Autor:
Erik Duijvelaar, Job R Schippers, Patrick J Smeele, Michiel Alexander de Raaf, Arthur L E M Vanhove, Siebe G Blok, CounterCOVID Collaborative Group, Jos W R Twisk, Anton Vonk Noordegraaf, Frances S de Man, Harm Jan Bogaard, Jurjan Aman
Long-term clinical outcomes of COVID-19 patients treated with imatinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::6562d0ff3effc4d68e81fc463e126a50
https://zenodo.org/record/7635519
https://zenodo.org/record/7635519
Autor:
Josien Smits, Marleen Kemper, Jessy Van Wezenbeek, Wim Boersma, Patrick J Smeele, Lucas R Celant, Erik Duijvelaar, Wouter Hoefsloot, Pierre M Bet, Leo M. A. Heunks, M.J. Overbeek, Anton Vonk Noordegraaf, Carol Pamplona, Marry R. Smit, Laurien M.A. Oswald, Ary Serpa Neto, Jurjan Aman, Herman M.A. Hofstee, Job R Schippers, Katrien Eger, Ivo van der Lee, Janneke E Stalenhoef, Miranda Geelhoed, Arthur L E M Vanhove, Nienke Paternotte, Karin A. Boomars, Azar Kianzad, Frank W.J.M. Smeenk, Esther J. Nossent, Adinda Mieras, Elise M A Slob, Jeroen N. Wessels, Michel M. van den Heuvel, Yurika L E van Glabbeek, Chris Happé, Renate Kos, Anke-Hilse Maitland-van der Zee, Nicole P. Juffermans, Laurien Van Der Lee, Imke H Bartelink, Pieter R. Tuinman, Gert-Jan Braunstahl, Peter W.A. Kunst, Marcus J. Schultz, Laura A. Hagens, Romke Hoekstra, Niels Pronk, Lieuwe D. J. Bos, Frances Handoko-De Man, Hans P. Grotjohan, Sara Azhang, Michiel Alexander de Raaf, Liza Botros, Peter I. Bonta, Pearl Mau-Asam, Rianne J A Hoek, Harm Jan Bogaard, Job J.M.H. van Bragt, Marije Lammers
Publikováno v:
Aman, J, Duijvelaar, E, Botros, L, Kianzad, A, Schippers, J, Smeele, P, Azhang, S, Bartelink, I, Bet, P, Boersma, W, Boomars, K, Bonta, P, Bos, L, Van Bragt, J, Braunstahl, G-J, Celant, L, Eger, K, Geelhoed, M, Van Glabbeek, Y, Grotjohan, H, Hagens, L, Happe, C, Heunks, L, Van Den Heuvel, M, Hoefsloot, W, Hoek, R, Hoekstra, R, Hofstee, H, Vanhove, A, Juffermans, N, Lammers, M, Kos, R, Kemper, M, Kunst, P, Van Der Lee, I, Van Der Lee, L, Mau-Asam, P, Maitland-Van Der Zee, A-H, Mieras, A, Nossent, E, Overbeek, M, Oswald, L, Paternotte, N, Pamplona, C, Pronk, N, De Raaf, M, Slob, E, Neto, A S, Schultz, M, Smit, M, Smeenk, F, Smits, J, Stalenhoef, J, Tuinman, P R, Wessels, J, Van Wezenbeek, J, Noordegraaf, A V, Handoko-De Man, F & Bogaard, H J 2021, ' Late Breaking Abstract-A randomised, double-blind, placebo controlled, clinical trial evaluating imatinib in patients with severe COVID-19 ', European Respiratory Journal, vol. 58 . https://doi.org/10.1183/13993003.congress-2021.OA4119
European Respiratory Journal
Airway cell biology and immunopathology
European Respiratory Journal, 58. European Respiratory Society
European Respiratory Journal
Airway cell biology and immunopathology
European Respiratory Journal, 58. European Respiratory Society
Autor:
Job J.M.H. van Bragt, Michiel Alexander de Raaf, Harm Jan Bogaard, Pierre M Bet, Azar Kianzad, Merlijn Reijrink, Esther J. Nossent, Job R Schippers, Lucas R Celant, Lieuwe D. J. Bos, Jeroen N. Wessels, Mirte Muller, Chris Happé, Niels Pronk, Anton Vonk Noordegraaf, Leo M. A. Heunks, Liza Botros, E Marleen Kemper, Wim Boersma, Michel van den Heuvel, Hans P Grotjohan, Rianne J A Hoek, Carolina C Pamplona, Sara Azhang, Nicole P. Juffermans, Marry R Smit, Ivo van der Lee, Imke H Bartelink, Bas F M van Raaij, Janneke E Stalenhoef, Wouter Hoefsloot, Pieter R. Tuinman, Ariana Lammers, Katrien Eger, Boaz D Hazes, E Laurien van der Lee, Karin A T Boomars, Arthur L E M Vanhove, Frances S. de Man, Laura A Hagens, Anke-Hilse Maitland-van der Zee, Elisabeth C W Neefjes, Marcus J. Schultz, Pearl F M Mau Asam, Erik Duijvelaar, Patrick J Smeele, A. Josien Smits, Frank W J M Smeenk, Elise M A Slob, Laurien M A Oswald, Ary Serpa Neto, J. J. Miranda Geelhoed, Jessie Van Wezenbeek, Gert-Jan Braunstahl, Herman M A Hofstee, Romke Hoekstra, Peter I. Bonta, Jurjan Aman, Nienke Paternotte, Renate Kos, Ahmed A. Bayoumy, Peter W A Kunst, Maria J Overbeek, Adinda Mieras, Yurika L E van Glabbeek
Publikováno v:
lancet. Respiratory medicine, 9(9), 957-968. Elsevier Limited
The Lancet Respiratory Medicine, 9(9), 957-968. ELSEVIER SCI LTD
The Lancet Respiratory Medicine, 9(9), 957-968. Elsevier Ltd.
Lancet Respiratory Medicine, 9, 957-968
Aman, J, Duijvelaar, E, Botros, L, Kianzad, A, Schippers, J R, Smeele, P J, Azhang, S, Bartelink, I H, Bayoumy, A A, Bet, P M, Boersma, W, Bonta, P I, Boomars, K A T, Bos, L D J, van Bragt, J J M H, Braunstahl, G-J, Celant, L R, Eger, K A B, Geelhoed, J J M, van Glabbeek, Y L E, Grotjohan, H P, Hagens, L A, Happe, C M, Hazes, B D, Heunks, L M A, van den Heuvel, M, Hoefsloot, W, Hoek, R J A, Hoekstra, R, Hofstee, H M A, Juffermans, N P, Kemper, E M, Kos, R, Kunst, P W A, Lammers, A, van der Lee, I, van der Lee, E L, Maitland-van der Zee, A-H, Mau Asam, P F M, Mieras, A, Muller, M, Neefjes, L, Nossent, E J, Oswald, L M A, Overbeek, M J, Pamplona, C, Paternotte, N, Pronk, N, de Raaf, M A, van Raaij, B F M, Reijrink, M, Schultz, M J, Serpa Neto, A, Slob, E M, Smeenk, F W J M, Smit, M R, Smits, A J, Stalenhoef, J E, Tuinman, P R, Vanhove, A L E M, Wessels, J N, van Wezenbeek, J C C, Vonk Noordegraaf, A, de Man, F S & Bogaard, H J 2021, ' Imatinib in patients with severe COVID-19 : a randomised, double-blind, placebo-controlled, clinical trial ', Lancet respiratory medicine, vol. 9, no. 9, pp. 957-968 . https://doi.org/10.1016/S2213-2600(21)00237-X
The Lancet. Respiratory Medicine
Lancet respiratory medicine, 9(9), 957-968. Elsevier Limited
Lancet Respiratory Medicine, 9, 9, pp. 957-968
The Lancet Respiratory Medicine
The Lancet Respiratory Medicine, 9(9), 957-968. ELSEVIER SCI LTD
The Lancet Respiratory Medicine, 9(9), 957-968. Elsevier Ltd.
Lancet Respiratory Medicine, 9, 957-968
Aman, J, Duijvelaar, E, Botros, L, Kianzad, A, Schippers, J R, Smeele, P J, Azhang, S, Bartelink, I H, Bayoumy, A A, Bet, P M, Boersma, W, Bonta, P I, Boomars, K A T, Bos, L D J, van Bragt, J J M H, Braunstahl, G-J, Celant, L R, Eger, K A B, Geelhoed, J J M, van Glabbeek, Y L E, Grotjohan, H P, Hagens, L A, Happe, C M, Hazes, B D, Heunks, L M A, van den Heuvel, M, Hoefsloot, W, Hoek, R J A, Hoekstra, R, Hofstee, H M A, Juffermans, N P, Kemper, E M, Kos, R, Kunst, P W A, Lammers, A, van der Lee, I, van der Lee, E L, Maitland-van der Zee, A-H, Mau Asam, P F M, Mieras, A, Muller, M, Neefjes, L, Nossent, E J, Oswald, L M A, Overbeek, M J, Pamplona, C, Paternotte, N, Pronk, N, de Raaf, M A, van Raaij, B F M, Reijrink, M, Schultz, M J, Serpa Neto, A, Slob, E M, Smeenk, F W J M, Smit, M R, Smits, A J, Stalenhoef, J E, Tuinman, P R, Vanhove, A L E M, Wessels, J N, van Wezenbeek, J C C, Vonk Noordegraaf, A, de Man, F S & Bogaard, H J 2021, ' Imatinib in patients with severe COVID-19 : a randomised, double-blind, placebo-controlled, clinical trial ', Lancet respiratory medicine, vol. 9, no. 9, pp. 957-968 . https://doi.org/10.1016/S2213-2600(21)00237-X
The Lancet. Respiratory Medicine
Lancet respiratory medicine, 9(9), 957-968. Elsevier Limited
Lancet Respiratory Medicine, 9, 9, pp. 957-968
The Lancet Respiratory Medicine
Background The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental and early clinical data suggest that the tyrosine-kinase inhibitor imatinib reverses pulmonary capillary leak. Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b9388602de3565960dbc68949c8a0a
https://pure.amc.nl/en/publications/imatinib-in-patients-with-severe-covid19(40a385b0-de53-45cd-aff2-cb6b5cdfc6d3).html
https://pure.amc.nl/en/publications/imatinib-in-patients-with-severe-covid19(40a385b0-de53-45cd-aff2-cb6b5cdfc6d3).html
Autor:
Yennece W.F. Dagelet, Susanne J. H. Vijverberg, Binbin Xu, Anke H. Maitland-van der Zee, Louwrina H Te Nijenhuis, Erik Duijvelaar, Ariana Lammers, René Lutter, Anirban Sinha, Rianne de Vries, Anne H. Neerincx, Peter J. Sterk, Mahmoud I. Abdel-Aziz, Paul Brinkman, Urs Frey
Publikováno v:
Allergy: European Journal of Allergy and Clinical Immunology, 76(8), 2488-2499. Wiley-Blackwell
Allergy
Allergy, Wiley, 2021, 76 (8), pp.Pages 2488-2499. ⟨10.1111/all.14811⟩
Allergy
Allergy, Wiley, 2021, 76 (8), pp.Pages 2488-2499. ⟨10.1111/all.14811⟩
Background Early detection/prediction of flare‐ups in asthma, commonly triggered by viruses, would enable timely treatment. Previous studies on exhaled breath analysis by electronic nose (eNose) technology could discriminate between stable and unst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f9bcc637b1d7e4acc68c36225ecc69
https://pure.amc.nl/en/publications/increased-daytoday-fluctuations-in-exhaled-breath-profiles-after-a-rhinovirus-challenge-in-asthma(19eb7fd0-d4f6-45ee-bb11-3285cf7eb3b4).html
https://pure.amc.nl/en/publications/increased-daytoday-fluctuations-in-exhaled-breath-profiles-after-a-rhinovirus-challenge-in-asthma(19eb7fd0-d4f6-45ee-bb11-3285cf7eb3b4).html