Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Erik C. Dreaden"'
Autor:
Rae Hunter, Kathleen J. Imbach, Chengjing Zhou, Jodi Dougan, Jamie A. G. Hamilton, Kevin Z. Chen, Priscilla Do, Ashley Townsel, Greg Gibson, Erik C. Dreaden, Edmund K. Waller, Karmella A. Haynes, Curtis J. Henry, Christopher C. Porter
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Immunotherapies have revolutionized the treatment of B-cell acute lymphoblastic leukemia (B-ALL), but the duration of responses is still sub-optimal. We sought to identify mechanisms of immune suppression in B-ALL and strategies to overcome
Externí odkaz:
https://doaj.org/article/ef01154c5f714e0194d19821d23e87c0
Autor:
Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, Wen Zhou, Sanjeev S. Dhara, Ganapathy Sriram, Fred C. Lam, Jesse C. Patterson, Mohiuddin Quadir, Anh Dinh, Kevin E. Shopsowitz, Shohreh Varmeh, Ömer H. Yilmaz, Stephen J. Lippard, H. Christian Reinhardt, Michael T. Hemann, Paula T. Hammond, Michael B. Yaffe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity t
Externí odkaz:
https://doaj.org/article/968af14e7f93410d8098ad17f0bc993d
Autor:
Yi Wen Kong, Erik C Dreaden
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/ec0de3f123fd40409fc39324089d380c
Autor:
Lacey A. Birnbaum, Emily C. Sullivan, Priscilla Do, Biaggio Uricoli, Sunil S. Raikar, Christopher C. Porter, Curtis J. Henry, Erik C. Dreaden
Publikováno v:
Biomacromolecules. 24:1164-1172
Autor:
Paula T. Hammond, Michael B. Yaffe, Ronny Drapkin, Kasper Renggli, Kevin E. Shopsowitz, Ki Young Choi, Santiago Correa, Stephen W. Morton, Yi Wen Kong, Erik C. Dreaden
Fig. S1. Drug-interaction matrix plotting cell killing observed in excess of the additive Bliss expectation between MEK and PI3K inhibition in Pt-resistant epithelial ovarian carcinoma (OVCAR3; 0.20-100 microM, 48 h).Ï‘ Fig. S2. Changes in serum c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1ee25eecc8d5e2aaf7f60ca3659121
https://doi.org/10.1158/1078-0432.22458524.v1
https://doi.org/10.1158/1078-0432.22458524.v1
Autor:
Paula T. Hammond, Michael B. Yaffe, Ronny Drapkin, Kasper Renggli, Kevin E. Shopsowitz, Ki Young Choi, Santiago Correa, Stephen W. Morton, Yi Wen Kong, Erik C. Dreaden
Purpose: Cross-talk and feedback between the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR cell signaling pathways is critical for tumor initiation, maintenance, and adaptive resistance to targeted therapy in a variety of solid tumors. Combined blockade of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad99918bb70ff1d32ec9d8f12ddcd5e9
https://doi.org/10.1158/1078-0432.c.6523976.v1
https://doi.org/10.1158/1078-0432.c.6523976.v1
Autor:
James M Kelvin, Juhi Jain, Aashis Thapa, Min Qui, Lacey A Birnbaum, Samuel G Moore, Henry Zecca, Ryan J Summers, Emma Costanza, Biaggio Uricoli, Xiaodong Wang, Nathan T Jui, Haian Fu, Yuhong Du, Deborah DeRyckere, Douglas K Graham, Erik C Dreaden
Publikováno v:
bioRxiv
Although high-dose, multi-agent chemotherapy has improved leukemia survival rates in recent years, treatment outcomes remain poor in high-risk subsets, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) in infants. Developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20c513cec49d15233ba1559f89fa08e
https://europepmc.org/articles/PMC10054973/
https://europepmc.org/articles/PMC10054973/
Autor:
Ryan J. Summers, Juhi Jain, Eleana Vasileiadi, Brittany Smith, Madison L. Chimenti, Tsz Y. Yeung, James Kelvin, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp, Jeffrey W. Tyner, Erik C. Dreaden, Deborah DeRyckere, Douglas K. Graham
Publikováno v:
Cancers; Volume 14; Issue 24; Pages: 6142
T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of childhood ALL. The early T-precursor (ETP-ALL) subset is characterized by an immature T-cell phenotype, chemoresistance, and high rates of induction failure. MERTK receptor tyrosine kina
Autor:
Lacey A Birnbaum, Emily C. Sullivan, Priscilla Do, Biaggio Uricoli, Christopher C Porter, Curtis J Henry, Erik C Dreaden
Cytokines act as potent, extracellular signals of the human immune system and can elicit striking treatment responses in patients with autoimmune disease, tissue damage, and cancer. Yet despite their therapeutic potential, recombinant cytokine-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e89cd1641bdb7e28b8cf222f0d4bd4a8
https://doi.org/10.1101/2022.10.03.510638
https://doi.org/10.1101/2022.10.03.510638
Autor:
James M Kelvin, Dan Y Zhang, Evelyn K Williams, Samuel G Moore, Lacey A Birnbaum, Henry Zecca, Xiaodong Wang, Juhi Jain, Min Qui, Nathan T Jui, Haian Fu, Yuhong Du, Melissa L Kemp, Wilbur A Lam, Deborah DeRyckere, Douglas K Graham, Erik C Dreaden
Advances in multiagent chemotherapy have led to recent improvements in overall survival for patients with acute lymphoblastic leukemia (ALL); however, a significant fraction do not respond to frontline chemotherapy or later relapse with recurrent dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a2b58cc55ed9e08259c1b6659a4eca8
https://doi.org/10.1101/2022.09.21.508196
https://doi.org/10.1101/2022.09.21.508196