Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Erik Bonke"'
Publikováno v:
MedChemComm. 8:657-661
By probing the quinone substrate binding site of mitochondrial complex I with a focused set of quinazoline-based compounds, we identified substitution patterns as being critical for the observed inhibition. The structure activity relationship study a
Publikováno v:
Free Radical Biology and Medicine. 99:43-53
Manganese-induced toxicity has been linked to mitochondrial dysfunction and an increased generation of reactive oxygen species (ROS). We could recently show in mechanistic studies that Mn2+ ions induce hydrogen peroxide (H2O2) production from the ubi
Autor:
Erik Bonke, Jochen Roeper, Heinrich Heide, Ivana Josipovic, Lea Schneider, Ilka Wittig, Matthias S. Leisegang, Stefan Dröse, Florian J Raimann, Kai Zacharowski, Juliana Heidler, Elisabeth Tybl, Jan Mersmann, Ralf P. Brandes
Publikováno v:
Journal of cardiovascular translational research. 12(5)
We have shown previously that during myocardial ischemia/reperfusion (MI/R), toll-like receptor 2 (TLR2) signaling regulates connexin 43 (Cx43) subcellular localization and function and dampens arrhythmia formation. We aimed to identify sites capable
Publikováno v:
BIOspektrum. 26:555-555
Anlass des Erratums: Unter dem Original-Artikel hat die Funding Note gefehlt mit dem Hinweis bzgl. der Open Access Licence
Publikováno v:
Free radical biologymedicine. 99
Manganese-induced toxicity has been linked to mitochondrial dysfunction and an increased generation of reactive oxygen species (ROS). We could recently show in mechanistic studies that Mn
Publikováno v:
Archives of biochemistry and biophysics. 580
Manganese-induced toxicity has been recently associated with an increased ROS generation from mitochondrial complex II (succinate:ubiquinone oxidoreductase). To achieve a deeper mechanistic understanding how divalent manganese ions (Mn(2+)) could sti
Publikováno v:
Free Radical Biology and Medicine. 100:S20
The mitochondrial respiratory chain is a major source of cellular reactive oxygen species (ROS). Recent data indicate that beside the established H 2 O 2 /O 2 ●– -generators NADH-ubiquinone- (complex I) and the ubiquinone-cytrochrome c -oxidoredu