An exploration of the gut and environmental resistome in a community in northern Vietnam in relation to antibiotic use

Autor: Vu Thi Ngoc Bich, Le Viet Thanh, Pham Duy Thai, Tran Thi Van Phuong, Melissa Oomen, Christel Driessen, Erik Beuken, Tran Huy Hoang, H. Rogier van Doorn, John Penders, Heiman F. L. Wertheim

Publikováno v: Antimicrobial Resistance and Infection Control, Vol 8, Iss 1, Pp 1-10 (2019)

Abstract Background Antibiotic resistance is a major global public health threat. Antibiotic use can directly impact the antibiotic resistant genes (ARGs) profile of the human intestinal microbiome and consequently the environment through shedding. M

Externí odkaz: https://doaj.org/article/a81c2da0b4a84f5da1b81a40a3f4ef3c

Detection of the plasmid-mediated colistin-resistance gene mcr-1 in faecal metagenomes of Dutch travellers

Autor: Christian J. H. von Wintersdorff, Lieke B. van Alphen, Erik Beuken, John Penders, Petra F. G. Wolffs, Paul H. M. Savelkoul, Astrid M. L. Oude Lashof, Julius M. van Niekerk, Ellen E. Stobberingh, Christian J. P. A. Hoebe

Publikováno v: Journal of Antimicrobial Chemotherapy, 71(12), 3416-3419. Oxford University Press
von Wintersdorff, C J H, Wolffs, P F G, van Niekerk, J M, Beuken, E, van Alphen, L B, Stobberingh, E E, Lashof, A M L O, Hoebe, C J P A, Savelkoul, P H M & Penders, J 2016, ' Detection of the plasmid-mediated colistin-resistance gene mcr-1 in faecal metagenomes of Dutch travellers ', Journal of Antimicrobial Chemotherapy, vol. 71, no. 12, pp. 3416-3419 . https://doi.org/10.1093/jac/dkw328

Background: Recently, the first plasmid-mediated colistin-resistance gene, mcr-1, was reported. Colistin is increasingly used as an antibiotic of last resort for the treatment of infections caused by carbapenem-resistant bacteria, which have been rap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ef8b18e1f9bc3a2c441194619877d4
https://cris.maastrichtuniversity.nl/en/publications/35340f0a-6559-4b0f-a121-3d310d463992

Mutational analysis of the R33-encoded G protein-coupled receptor of rat cytomegalovirus: identification of amino acid residues critical for cellular localization and ligand-independent signalling

Autor: Erik Beuken, Martine J. Smit, Cathrien A. Bruggeman, Rob Leurs, Cornelis Vink, Yvonne K. Gruijthuijsen

Publikováno v: Journal of General Virology, 85(Pt 4), 897-909. Society for General Microbiology
Gruijthuijsen, Y K, Beuken, E V, Smit, M J, Leurs, R, Bruggeman, C A & Vink, C 2004, ' Mutational analysis of the R33-encoded G protein-coupled receptor of rat cytomegalovirus: identification of amino acid residues critical for cellular localization and ligand-independent signalling ', Journal of General Virology, vol. 85, no. Pt 4, pp. 897-909 . https://doi.org/10.1099/vir.0.19709-0

The rat cytomegalovirus (RCMV)R33gene encodes a G protein-coupled receptor (GPCR), pR33, which possesses agonist-independent, constitutive signalling activity. To characterize this activity further, we generated a series of point and deletion mutants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f36ef7a598aa4ab40abd4a06d9e8d0
https://doi.org/10.1099/vir.0.19709-0

Rat cytomegalovirus open reading frame R44 is an early-late gene that encodes a nuclear protein

Autor: Suzanne J.F. Kaptein, Gert Grauls, Cathrien A. Bruggeman, Erik Beuken, Cornelis Vink

Publikováno v: Archives of Virology. 146:2211-2218

Rat cytomegalovirus (RCMV) open reading frame R44 is the homolog of human cytomegalovirus gene UL44, which encodes the DNA polymerase accessory protein. Here, we show that R44 is transcribed as a 3.6-kb mRNA within the early and late phases of infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54de50030be0c9a65db3fb9dbdf401ab
https://doi.org/10.1007/s007050170031

The Maastricht Strain and England Strain of Rat Cytomegalovirus Represent Different Betaherpesvirus Species Rather Than Strains

Autor: Cornelis Vink, Suzanne J.F. Kaptein, Patrick S. Beisser, Cathrien A. Bruggeman, Erik Beuken

Publikováno v: Virology. 246:341-351

The major immediate early (MIE) locus of the Maastricht strain of rat cytomegalovirus (RCMV) was found to comprise five exons of which the first is noncoding. The first three exons are spliced to either exon 4, generating IE1, or exon 5, generating I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09edbee166f195cbed8229d6ff2a303
https://doi.org/10.1006/viro.1998.9196