Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Erik A. C. Wiemer"'
Autor:
Ruobing Wang, Yan Yang, Zhongyin Zhang, Na Zhao, Erik A. C. Wiemer, Jingjing Ben, Junqing Ma, Lichan Yuan
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-11 (2023)
Abstract Osteoclasts (OCs), derived from monocyte/macrophage lineage, are key orchestrators in bone remodeling. Targeting osteoclast apoptosis is a promising approach to cut down excessive osteoclast numbers, and thus slow down the rate of bone mass
Externí odkaz:
https://doaj.org/article/44d964bdae3947678f8dd3422a4a6ffc
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Lipid rafts, also known as microdomains, are important components of cell membranes and are enriched in cholesterol, glycophospholipids and receptors. They are involved in various essential cellular processes, including endocytosis, exocytosis and ce
Externí odkaz:
https://doaj.org/article/5474c56fa5ad4da1a967b56da87a2b98
Autor:
Esmee Koedoot, Michiel Fokkelman, Vasiliki-Maria Rogkoti, Marcel Smid, Iris van de Sandt, Hans de Bont, Chantal Pont, Janna E. Klip, Steven Wink, Mieke A. Timmermans, Erik A. C. Wiemer, Peter Stoilov, John A. Foekens, Sylvia E. Le Dévédec, John W. M. Martens, Bob van de Water
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Triple-negative breast cancers (TNBC) have enhanced migratory behaviour. Here, the authors perform a phenotypic imaging-based RNAi screen to identify several genes associated with regulation of migratory phenotypes and show that one of the regulators
Externí odkaz:
https://doaj.org/article/720606fcf5f54cc0ae38a7db6f491bec
Autor:
Jingjing Ben, Bin Jiang, Dongdong Wang, Qingling Liu, Yongjing Zhang, Yu Qi, Xing Tong, Lili Chen, Xianzhong Liu, Yan Zhang, Xudong Zhu, Xiaoyu Li, Hanwen Zhang, Hui Bai, Qing Yang, Junqing Ma, Erik A. C. Wiemer, Yong Xu, Qi Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Metabolic diseases are associated with chronic, low-grade inflammation. Here the authors show that major vault protein (MVP) suppresses NF-κB signalling in macrophages via an IRAK1–TRAF6 axis and that loss of MVP in myeloid cells exacerbates the i
Externí odkaz:
https://doaj.org/article/df9e7fb64e9a474d90bab5fb250c8b3f
Autor:
Milea J. M. Timbergen, Ruben Boers, Anne L. M. Vriends, Joachim Boers, Wilfred F. J. van IJcken, Marla Lavrijsen, Dirk J. Grünhagen, Cornelis Verhoef, Stefan Sleijfer, Ron Smits, Joost Gribnau, Erik A. C. Wiemer
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
IntroductionThe majority of desmoid-type fibromatosis (DTF) tumors harbor a β-catenin mutation, affecting specific codons in CTNNB1 exon 3. S45F tumors are reported to have a higher chance of recurrence after surgery and more resistance to systemic
Externí odkaz:
https://doaj.org/article/5a25b29956a948f185e222b601fec78d
Autor:
Milea J. M. Timbergen, Ron Smits, Dirk J. Grünhagen, Cornelis Verhoef, Stefan Sleijfer, Erik A. C. Wiemer
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Desmoid-type fibromatosis (DTF) is a rare, soft tissue tumor of mesenchymal origin which is characterized by local infiltrative growth behavior. Besides “wait and see,” surgery and radiotherapy, several systemic treatments are available for sympt
Externí odkaz:
https://doaj.org/article/52eba05871684ed1b8392c3271f37423
Autor:
Josep, Rayo, Rachel, Gregor, Nicholas T, Jacob, Rambabu, Dandela, Luba, Dubinsky, Alex, Yashkin, Alexander, Aranovich, Manikandan, Thangaraj, Orna, Ernst, Eran, Barash, Sergey, Malitsky, Bogdan I, Florea, Bastiaan P, Krom, Erik A C, Wiemer, Valerie A, Kickhoefer, Leonard H, Rome, John C, Mathison, Gunnar F, Kaufmann, Herman S, Overkleeft, Benjamin F, Cravatt, Tsaffrir, Zor, Kim D, Janda, Richard J, Ulevitch, Vladimir V, Kravchenko, Michael M, Meijler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance It has become clear that our immune system can significantly inhibit the growth of cancer cells, in a process that has been coined “cancer immunoediting.” Based on this model, if the programmed cell death (apoptosis) mediated through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::361155687a6e546556690dc191c10b8f
https://pubmed.ncbi.nlm.nih.gov/33723037
https://pubmed.ncbi.nlm.nih.gov/33723037
Autor:
Caroline M M, Gits, Patricia F, van Kuijk, Moniek B E, Jonkers, Antonius W M, Boersma, Marcel, Smid, Wilfred F, van Ijcken, Jean-Michel, Coindre, Fréderic, Chibon, Cornelis, Verhoef, Ron H J, Mathijssen, Michael A, den Bakker, Jaap, Verweij, Stefan, Sleijfer, Erik A C, Wiemer
Publikováno v:
International journal of cancer. 135(2)
Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into four histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but neverthel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::620c378b69eb47e891470d6f22794adf
https://pubmed.ncbi.nlm.nih.gov/24375455
https://pubmed.ncbi.nlm.nih.gov/24375455
Autor:
Herman, Burger, John A, Foekens, Maxime P, Look, Marion E, Meijer-van Gelder, Jan G M, Klijn, Erik A C, Wiemer, Gerrit, Stoter, Kees, Nooter
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(2)
The aim of this study was to investigate whether expression of particular drug resistance genes in primary operable breast cancer correlates with response to first-line chemotherapy in advanced disease.We determined mRNA levels of BCRP, LRP, MRP1, MR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6359b94fcf4004f263637c8673ef858
https://pubmed.ncbi.nlm.nih.gov/12576456
https://pubmed.ncbi.nlm.nih.gov/12576456
Autor:
Marieke H, Mossink, Arend, van Zon, Erna, Fränzel-Luiten, Martijn, Schoester, Valerie A, Kickhoefer, George L, Scheffer, Rik J, Scheper, Pieter, Sonneveld, Erik A C, Wiemer
Publikováno v:
Cancer research. 62(24)
Vaults are ribonucleoprotein particles with a distinct structure and a high degree of conservation between species. Although no function has been assigned to the complex yet, there is some evidence for a role of vaults in multidrug resistance. To con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43be9073bb4a9b3efd25429c4754c454
https://pubmed.ncbi.nlm.nih.gov/12499273
https://pubmed.ncbi.nlm.nih.gov/12499273