Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Erik A Lundquist"'
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0295701 (2024)
The Polarity/Protusion model of UNC-6/Netrin function in axon repulsion does not rely on a gradient of UNC-6/Netrin. Instead, the UNC-5 receptor polarizes the VD growth cone such that filopodial protrusions are biased to the dorsal leading edge. UNC-
Externí odkaz:
https://doaj.org/article/6c8b00b77b19405ca403f43a180b8b37
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1007960 (2019)
UNC-6/Netrin is a conserved axon guidance cue that directs growth cone migrations in the dorsal-ventral axis of C. elegans and in the vertebrate spinal cord. UNC-6/Netrin is expressed in ventral cells, and growth cones migrate ventrally toward or dor
Externí odkaz:
https://doaj.org/article/69bf209dabf04eebbc93987a456e2c41
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006998 (2017)
The guidance cue UNC-6/Netrin regulates both attractive and repulsive axon guidance. Our previous work showed that in C. elegans, the attractive UNC-6/Netrin receptor UNC-40/DCC stimulates growth cone protrusion, and that the repulsive receptor, an U
Externí odkaz:
https://doaj.org/article/a0b7d08eb935499fabdbf9a43044415b
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148658 (2016)
Directed neuroblast and neuronal migration is important in the proper development of nervous systems. In C. elegans the bilateral Q neuroblasts QR (on the right) and QL (on the left) undergo an identical pattern of cell division and differentiation b
Externí odkaz:
https://doaj.org/article/0fd8eada29434b64902698d0233cb60e
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002665 (2012)
The mechanisms linking guidance receptors to cytoskeletal dynamics in the growth cone during axon extension remain mysterious. The Rho-family GTPases Rac and CDC-42 are key regulators of growth cone lamellipodia and filopodia formation, yet little is
Externí odkaz:
https://doaj.org/article/9cc75bbe6cfe4ac1acccfadfcbe674b4
Autor:
Rafael S Demarco, Erik A Lundquist
Publikováno v:
PLoS Genetics, Vol 6, Iss 11, p e1001215 (2010)
Migrating cells and growth cones extend lamellipodial and filopodial protrusions that are required for outgrowth and guidance. The mechanisms of cytoskeletal regulation that underlie cell and growth cone migration are of much interest to developmenta
Externí odkaz:
https://doaj.org/article/bc5b02292b684b79b47a62a230208f64
Autor:
Erik A Lundquist
Publikováno v:
PLoS Biology, Vol 7, Iss 6, p e1000142 (2009)
Externí odkaz:
https://doaj.org/article/82ee0a94180847ffb987e2088bf7fd78
Publikováno v:
bioRxiv
In the Polarity/Protusion model of growth cone migration away from the guidance cue UNC-6/Netrin, the UNC-5 receptor polarizes the VD growth cone such that filopodial protrusions are biased to the dorsal leading edge of the growth cone. UNC-5 also in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25c5ceefe02b6c29877952c34bf211d
https://europepmc.org/articles/PMC10245697/
https://europepmc.org/articles/PMC10245697/
Autor:
Snehal S. Mahadik, Erik A. Lundquist
Publikováno v:
bioRxiv
UNC-6/Netrin is a conserved bi-functional guidance cue which regulates dorsal-ventral axon guidance inC. elegans. In the Polarity/Protrusion model of UNC-6/Netrin mediated dorsal growth away from UNC-6/Netrin, The UNC-5 receptor first polarizes the V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fa5a3d78c24e88b5a5a0501d127acb
https://europepmc.org/articles/PMC10187218/
https://europepmc.org/articles/PMC10187218/
Autor:
Snehal S. Mahadik, Erik A. Lundquist
Publikováno v:
Development. 150
In the polarity/protrusion model of growth cone repulsion from UNC-6/Netrin, UNC-6 first polarizes the VD growth cone via the UNC-5 receptor, and then regulates protrusion asymmetrically across the growth cone based on this polarity. Through the UNC-