Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Erik A L Biessen"'
Autor:
Han Jin, Cheng Zhang, Jan Nagenborg, Peter Juhasz, Adele V. Ruder, Cornelis J. J. M. Sikkink, Barend M. E. Mees, Olivia Waring, Judith C. Sluimer, Dietbert Neumann, Pieter Goossens, Marjo M. P. C. Donners, Adil Mardinoglu, Erik A. L. Biessen
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background Metabolism is increasingly recognized as a key regulator of the function and phenotype of the primary cellular constituents of the atherosclerotic vascular wall, including endothelial cells, smooth muscle cells, and inflammatory c
Externí odkaz:
https://doaj.org/article/abf30882fa56414492f4965ea2f6957e
Autor:
Marjo M P C Donners, Lili Bai, Suzanne P M Lutgens, Erwin Wijnands, Jason Johnson, Leon J Schurgers, Cong-Lin Liu, Mat J A P Daemen, Kitty B J M Cleutjens, Guo-Ping Shi, Erik A L Biessen, Sylvia Heeneman
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162595 (2016)
Cathepsin K (catK) is a potent lysosomal cysteine protease involved in extracellular matrix (ECM) degradation and inflammatory remodeling responses. Here we have investigated the contribution of catK deficiency on carotid arterial remodeling in respo
Externí odkaz:
https://doaj.org/article/a5988cfc01dd4c8599b1bd09867af1c3
Autor:
Dennis H M Kusters, Martijn L Chatrou, Brecht A G Willems, Marijke De Saint-Hubert, Matthias Bauwens, Emiel van der Vorst, Stefania Bena, Erik A L Biessen, Mauro Perretti, Leon J Schurgers, Chris P M Reutelingsperger
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130484 (2015)
To investigate therapeutic effects of annexin A1 (anxA1) on atherogenesis in LDLR-/- mice.Human recombinant annexin A1 (hr-anxA1) was produced by a prokaryotic expression system, purified and analysed on phosphatidylserine (PS) binding and formyl pep
Externí odkaz:
https://doaj.org/article/5f757913e6a44b8b800fc542683635ea
Autor:
Anjana Singh, Adriaan O. Kraaijeveld, Adelina Curaj, Kanin Wichapong, Linda Hammerich, Saskia C. A. de Jager, Ilze Bot, Sergei P. Atamas, Theo J. C. van Berkel, J. Wouter Jukema, Iain Comerford, Shaun R. McColl, Barend Mees, Johan W. M. Heemskerk, Gerry A. F. Nicolaes, Tilman Hackeng, Elisa Anamaria Liehn, Frank Tacke, Erik A. L. Biessen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes prompted an investigation into the r
Externí odkaz:
https://doaj.org/article/573017efcc53412a84624e171b71058e
Autor:
Julian I Borissoff, Jeroen J T Otten, Sylvia Heeneman, Peter Leenders, René van Oerle, Oliver Soehnlein, Sarah T B G Loubele, Karly Hamulyák, Tilman M Hackeng, Mat J A P Daemen, Jay L Degen, Hartmut Weiler, Charles T Esmon, Joanne van Ryn, Erik A L Biessen, Henri M H Spronk, Hugo ten Cate
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55784 (2013)
BACKGROUND: Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects of coagulation proteases. Published experimental studies have yielded
Externí odkaz:
https://doaj.org/article/0d40d4d7178745408a7059d1141ca157
Autor:
Carlos L J Vrins, Ruud Out, Peter van Santbrink, André van der Zee, Tokameh Mahmoudi, Martine Groenendijk, Louis M Havekes, Theo J C van Berkel, Ko Willems van Dijk, Erik A L Biessen
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57492 (2013)
BACKGROUND: The zinc finger protein Znf202 is a transcriptional suppressor of lipid related genes and has been linked to hypoalphalipoproteinemia. A functional role of Znf202 in lipid metabolism in vivo still remains to be established. METHODOLOGY AN
Externí odkaz:
https://doaj.org/article/f27b3ab967384e6da9e293fa14bed075
Autor:
Martine Bot, Paul P Van Veldhoven, Saskia C A de Jager, Jason Johnson, Niels Nijstad, Peter J Van Santbrink, Marijke M Westra, Gerd Van Der Hoeven, Marion J Gijbels, Carsten Müller-Tidow, Georg Varga, Uwe J F Tietge, Johan Kuiper, Theo J C Van Berkel, Jerzy-Roch Nofer, Ilze Bot, Erik A L Biessen
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63360 (2013)
Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(
Externí odkaz:
https://doaj.org/article/1a0d95655b81411ea2e0c24d8f384462
Autor:
Saskia C A de Jager, Brenda W C Bongaerts, Michael Weber, Adriaan O Kraaijeveld, Mat Rousch, Stefanie Dimmeler, Marja P van Dieijen-Visser, Kitty B J M Cleutjens, Patty J Nelemans, Theo J C van Berkel, Erik A L Biessen
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45804 (2012)
Cytokines play an important role in ischemic injury and repair. However, little is known about their prognostic value in cardiovascular disease. The aim of this study was to investigate the prognostic importance of chemokines CCL3/MIP-1α, CCL5/RANTE
Externí odkaz:
https://doaj.org/article/a245f1e15c894d60856f4a3540d041e6
Autor:
Kasinath Viswanathan, Ilze Bot, Liying Liu, Erbin Dai, Peter C Turner, Babajide Togonu-Bickersteth, Jakob Richardson, Jennifer A Davids, Jennifer M Williams, Mee Y Bartee, Hao Chen, Theo J C van Berkel, Erik A L Biessen, Richard W Moyer, Alexandra R Lucas
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44694 (2012)
Poxviruses express highly active inhibitors, including serine proteinase inhibitors (serpins), designed to target host immune defense pathways. Recent work has demonstrated clinical efficacy for a secreted, myxomaviral serpin, Serp-1, which targets t
Externí odkaz:
https://doaj.org/article/a5c6acf97d6f48ee9d839410654d30f7
Autor:
Chang Lu, Marjo M. P. C. Donners, Julius B. J. de Baaij, Han Jin, Jeroen J. T. Otten, Marco Manca, Anton Jan van Zonneveld, J. Wouter Jukema, Adriaan Kraaijeveld, Johan Kuiper, Gerard Pasterkamp, Barend Mees, Judith C. Sluimer, Rachel Cavill, Joël M. H. Karel, Pieter Goossens, Erik A. L. Biessen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe impact of cardiovascular disease (CVD) risk factors, encompassing various biological determinants and unhealthy lifestyles, on the functional dynamics of circulating monocytes—a pivotal cell type in CVD pathophysiology remains elusi
Externí odkaz:
https://doaj.org/article/acdcec591c4f4b49a2363032fe946ac9