Výsledky vyhledávání - "Erik A Farrar"

Akademický článek

IL-15 mediated expansion of rare durable memory T cells following adoptive cellular therapy

Autor: Robin L Jones, Erik A Farrar, Jianhong Cao, Venu G Pillarisetty, Stanley R Riddell, Jean Campbell, Brett A Schroeder, Ralph Graeme Black, Shihong Zhang, Karan Kohli, Robert H Pierce, Lu Yao, Theodore Scott Nowicki, Heather Sloan, Dawn Stief, Lee D Cranmer, Douglas S Hawkins, Edward Y Kim

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)

Background Synovial sarcoma (SS) and myxoid/round cell liposarcoma (MRCL) are ideal solid tumors for the development of adoptive cellular therapy (ACT) targeting NY-ESO-1, as a high frequency of tumors homogeneously express this cancer-testes antigen

Externí odkaz: https://doaj.org/article/7b2950dec24549d59f93f70ab1f87df2

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Akademický článek

NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine.

Autor: Seth M Pollack, Yonqing Li, Megan J Blaisdell, Erik A Farrar, Jeffrey Chou, Benjamin L Hoch, Elizabeth T Loggers, Eve Rodler, Janet F Eary, Ernest U Conrad, Robin L Jones, Cassian Yee

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32165 (2012)

Chondrosarcoma has no proven systemic option in the metastatic setting. The development of a non-cross-resistant strategy, such as cellular immunotherapy using antigen-specific T cells would be highly desirable. NY-ESO-1 and PRAME are members of the

Externí odkaz: https://doaj.org/article/15f22ce42fce4738b6fd8dcdaaf8bdee

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IL-15 mediated expansion of rare durable memory T cells following adoptive cellular therapy

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Journal for immunotherapy of cancer, vol 9, iss 5
Journal for Immunotherapy of Cancer

Author(s): Kohli, Karan; Yao, Lu; Nowicki, Theodore Scott; Zhang, Shihong; Black, Ralph Graeme; Schroeder, Brett A; Farrar, Erik A; Cao, Jianhong; Sloan, Heather; Stief, Dawn; Cranmer, Lee D; Wagner, Michael J; Hawkins, Douglas S; Pillarisetty, Venu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ed3b04ac00c150dd287258c909c5c0
https://doi.org/10.1136/jitc-2020-002232

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T-Cell Therapy Using Interleukin-21-Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression

Autor: Ilana M. Roberts, John A. Thompson, Kendall C. Shibuya, Jedd D. Wolchok, Ivy Lai, Aude G. Chapuis, Erik A. Farrar, Philip D. Greenberg, Shailender Bhatia, Felecia Wagener, Jianhong Cao, Kim Margolin, Cassian Yee, Heather L. Sloan, Sylvia Lee

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34(31)

Purpose Peripheral blood–derived antigen-specific cytotoxic T cells (CTLs) provide a readily available source of effector cells that can be administered with minimal toxicity in an outpatient setting. In metastatic melanoma, this approach results i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c3d387dd417346348d32b404e41422
https://pubmed.ncbi.nlm.nih.gov/27269940

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NY-ESO-1 is a ubiquitous immunotherapeutic target antigen for patients with myxoid/round cell liposarcoma

Autor: Benjamin Hoch, David J. Schneider, Achim A. Jungbluth, Cassian Yee, Elizabeth T. Loggers, Erik A. Farrar, Ernest U. Conrad, Eve T. Rodler, Janet F. Eary, Robin L. Jones, Marie Bleakley, Seth M. Pollack

Publikováno v: Cancer. 118:4564-4570

BACKGROUND: Myxoid/round cell liposarcoma (MRCL) is the second most common liposarcoma subtype, accounting for >33% of liposarcomas and approximately 10% of all soft tissue sarcomas. Although MRCL is a chemosensitive subtype, patients with metastatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::278a192e54a484e86aeda354b13b5878
https://doi.org/10.1002/cncr.27446

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Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype

Autor: Daniel E. Sabath, John A. Thompson, Rebecca Rodmyre, Kaye Dowdy, Erik A. Farrar, Shailender Bhatia, Jianhong Cao, Cassian Yee, Ivy Lai, Kim Margolin, Yongqing Li, Aude G. Chapuis

Adoptively transferred tumor-specific T cells offer the potential for non–cross-resistant therapy and long-term immunoprotection. Strategies to enhance in vivo persistence of transferred T cells can lead to improved antitumor efficacy. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee223611d86d017258b17ed5f720295d
https://europepmc.org/articles/PMC3311364/

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NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine

Autor: Robin L. Jones, Yonqing Li, Ernest U. Conrad, Seth M. Pollack, Benjamin Hoch, Cassian Yee, Megan J. Blaisdell, Jeffrey Chou, Erik A. Farrar, Elizabeth T. Loggers, Eve T. Rodler, Janet F. Eary

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 2, p e32165 (2012)

Background Chondrosarcoma has no proven systemic option in the metastatic setting. The development of a non-cross-resistant strategy, such as cellular immunotherapy using antigen-specific T cells would be highly desirable. NY-ESO-1 and PRAME are memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6c42e1ef1476aae5b5df263a37bd60
https://pubmed.ncbi.nlm.nih.gov/22384167

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Merkel cell polyomavirus-specific CD8⁺ and CD4⁺ T-cell responses identified in Merkel cell carcinomas and blood

Autor: Paul Nghiem, Joshua O. Marshak, Joseph J. Carter, Erik A. Farrar, Olga K. Afanasiev, Ivy Lai, Lichun Dong, Kotaro Nagase, Christopher M. McClurkan, Kelly G. Paulson, Denise A. Galloway, David R. Byrd, Cassian Yee, Jayasri G. Iyer, Lichen Jing, David M. Koelle

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 17(21)

Purpose: Merkel cell polyomavirus (MCPyV) is prevalent in the general population, integrates into most Merkel cell carcinomas (MCC), and encodes oncoproteins required for MCC tumor growth. We sought to characterize T-cell responses directed against v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32b0fb9d681a9cbfb276edefb231b6f
https://pubmed.ncbi.nlm.nih.gov/21908576

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NY-ESO-1 is a ubiquitous immunotherapeutic target antigen for patients with myxoid/round cell liposarcoma

Autor: Seth M, Pollack, Achim A, Jungbluth, Benjamin L, Hoch, Erik A, Farrar, Marie, Bleakley, David J, Schneider, Elizabeth T, Loggers, Eve, Rodler, Janet F, Eary, Ernest U, Conrad, Robin L, Jones, Cassian, Yee

Publikováno v: Cancer. 118(18)

Myxoid/round cell liposarcoma (MRCL) is the second most common liposarcoma subtype, accounting for33% of liposarcomas and approximately 10% of all soft tissue sarcomas. Although MRCL is a chemosensitive subtype, patients with metastatic disease have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99cc91a72d76ff2e357418fe50331a4f
https://pubmed.ncbi.nlm.nih.gov/22359263

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Abstract IA17: Merkel cell carcinoma therapy with viral oncoprotein-specific T cells in combination with immunostimulatory adjuvants

Autor: Olga K. Afanasiev, Ivy Lai, Ilana M. Roberts, Kelly G. Paulson, Kotaro Nagase, Aaron Seo, Erik A. Farrar, Paul Nghiem, Upendra Parvathaneni, Aude G. Chapuis, Joo Ha Hwang, Cassian Yee, David M. Koelle, Jayasri G. Iyer

Publikováno v: Cancer Research. 73:IA17-IA17

Persistent expression of Merkel cell polyomavirus (MCPyV) T antigen oncoproteins is required for the growth of most Merkel cell carcinomas (MCCs). MCPyV oncoproteins are thus attractive tumor antigens for evaluating the feasibility of antigen-specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f353cd9bd8c24f583c192ae749f415a
https://doi.org/10.1158/1538-7445.tumimm2012-ia17

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