Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Erik, Widen"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract In this paper we characterize the performance of linear models trained via widely-used sparse machine learning algorithms. We build polygenic scores and examine performance as a function of training set size, genetic ancestral background, an
Externí odkaz:
https://doaj.org/article/f45c50f7c3764934a2005a9c27f3cf63
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract We use UK Biobank and a unique IVF family dataset (including genotyped embryos) to investigate sibling variation in both phenotype and genotype. We compare phenotype (disease status, height, blood biomarkers) and genotype (polygenic scores,
Externí odkaz:
https://doaj.org/article/f97efd9e623b43db83c856dfa9fc6211
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract We construct a polygenic health index as a weighted sum of polygenic risk scores for 20 major disease conditions, including, e.g., coronary artery disease, type 1 and 2 diabetes, schizophrenia, etc. Individual weights are determined by popul
Externí odkaz:
https://doaj.org/article/5816da80f15549efb8dc47ae9549ba2b
Publikováno v:
Scientific reports. 13(1)
We use UK Biobank and a unique IVF family dataset (including genotyped embryos) to investigate sibling variation in both phenotype and genotype. We compare phenotype (disease status, height, blood biomarkers) and genotype (polygenic scores, polygenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df69dabc51c32d94efd156dd101c316
https://pubmed.ncbi.nlm.nih.gov/36611071
https://pubmed.ncbi.nlm.nih.gov/36611071
We use UK Biobank and a unique IVF family dataset (including genotyped embryos) to investigate sibling variation in both phenotype and genotype. We compare phenotype (disease status, height, blood biomarkers) and genotype (polygenic scores, polygenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee7a593e46726a093cb2d4385055500e
https://doi.org/10.1101/2022.09.17.22280057
https://doi.org/10.1101/2022.09.17.22280057
We construct a polygenic health index as a weighted sum of polygenic risk scores for 20 major disease conditions, including, e.g., coronary artery disease, type 1 and 2 diabetes, schizophrenia, etc. Individual weights are determined by population-lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ce5e87cf85c5e63bf5e91ff3cef31a
https://doi.org/10.1101/2022.06.15.22276102
https://doi.org/10.1101/2022.06.15.22276102
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2467
Decoding the genome confers the capability to predict characteristics of the organism (phenotype) from DNA (genotype). We describe the present status and future prospects of genomic prediction of complex traits in humans. Some highly heritable comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c10d81beb3bc4f0998ddceb4f6514bf
https://pubmed.ncbi.nlm.nih.gov/35451785
https://pubmed.ncbi.nlm.nih.gov/35451785
Autor:
Laurent Christian Asker Melchior Tellier, Nathan Robert Treff, Stephen Dao Hui Hsu, Louis Lello, Erik Widen
Publikováno v:
European Journal of Human Genetics. 31:278-278
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b087b9f504fbf4345e2c5420b20d61b
https://doi.org/10.1038/s41431-022-01237-0
https://doi.org/10.1038/s41431-022-01237-0
Publikováno v:
Genes
Volume 12
Issue 7
Genes, Vol 12, Iss 991, p 991 (2021)
Volume 12
Issue 7
Genes, Vol 12, Iss 991, p 991 (2021)
We use UK Biobank data to train predictors for 65 blood and urine markers such as HDL, LDL, lipoprotein A, glycated haemoglobin, etc. from SNP genotype. For example, our Polygenic Score (PGS) predictor correlates ∼0.76 with lipoprotein A level, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5da49850c3ce197d3c45e911a86b17a