Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Erik, Van Dis"'
Autor:
Xammy Nguyenla, Eddie Wehri, Erik Van Dis, Scott B. Biering, Livia H. Yamashiro, Chi Zhu, Julien Stroumza, Claire Dugast-Darzacq, Thomas G. W. Graham, Xuanting Wang, Steffen Jockusch, Chuanjuan Tao, Minchen Chien, Wei Xie, Dinshaw J. Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, James J. Russo, Jingyue Ju, Anders M. Näär, Sarah Stanley, Julia Schaletzky
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract SARS coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic with significant mortality and morbidity. At this time, the only FDA-approved therapeutic for COVID-19 is remdesivir, a broad-spectrum antiviral nucleoside analog. Efficac
Externí odkaz:
https://doaj.org/article/9e4aeb4597b84bd5b8c7f7298e96338a
Autor:
Chi Zhu, Justin Y. Lee, Jia Z. Woo, Lei Xu, Xammy Nguyenla, Livia H. Yamashiro, Fei Ji, Scott B. Biering, Erik Van Dis, Federico Gonzalez, Douglas Fox, Eddie Wehri, Arjun Rustagi, Benjamin A. Pinsky, Julia Schaletzky, Catherine A. Blish, Charles Chiu, Eva Harris, Ruslan I. Sadreyev, Sarah Stanley, Sakari Kauppinen, Silvi Rouskin, Anders M. Näär
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Despite approved vaccines and anti-virals to prevent and treat SARS-CoV-2 infection, there is a need for further development of efficient antiviral therapeutic strategy. Here, Zhu et al. develop locked nucleic acid antisense oligonucleotides (LNA ASO
Externí odkaz:
https://doaj.org/article/465980a86b3646a5914f997d2bfea608
Autor:
Huntly M Morrison, Julia Craft, Rafael Rivera-Lugo, Jeffery R Johnson, Guillaume R Golovkine, Samantha L Bell, Claire E Dodd, Erik Van Dis, Wandy L Beatty, Shally R Margolis, Teresa Repasy, Isaac Shaker, Angus Y Lee, Russell E Vance, Sarah A Stanley, Robert O Watson, Nevan J Krogan, Daniel A Portnoy, Bennett H Penn, Jeffery S Cox
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011088 (2023)
Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-conta
Externí odkaz:
https://doaj.org/article/bb529b2bbf75461d932dc89cb0aeb02a
Autor:
Celine Perier, Emmanuel Nasinghe, Isabelle Charles, Leoson Junior Ssetaba, Vida Ahyong, Derek Bangs, P. Robert Beatty, Nadine Czudnochowski, Amy Diallo, Eli Dugan, Jacqueline M. Fabius, Hildy Fong Baker, Jackson Gardner, Stephen Isaacs, Birungi Joanah, Katrina Kalantar, David Kateete, Matt Knight, Maria Krasilnikov, Nevan J. Krogan, Chaz Langelier, Eric Lee, Lucy M. Li, Daniel Licht, Katie Lien, Zilose Lyons, Gerald Mboowa, Ivan Mwebaza, Savannah Mwesigwa, Geraldine Nalwadda, Robert Nichols, Maria Elena Penaranda, Sarah Petnic, Maira Phelps, Stephen J. Popper, Michael Rape, Arthur Reingold, Richard Robbins, Oren S. Rosenberg, David F. Savage, Samuel Schildhauer, Matthew L. Settles, Ivan Sserwadda, Sarah Stanley, Cristina M. Tato, Alexandra Tsitsiklis, Erik Van Dis, Manu Vanaerschot, Joanna Vinden, Jeffery S. Cox, Moses L. Joloba, Julia Schaletzky
Publikováno v:
Global Health Action, Vol 15, Iss 1 (2022)
Science education and research have the potential to drive profound change in low- and middle-income countries (LMICs) through encouraging innovation, attracting industry, and creating job opportunities. However, in LMICs, research capacity is often
Externí odkaz:
https://doaj.org/article/a7c38009f6404c1d8f6807180da59309
Autor:
Erik Van Dis, Douglas M Fox, Huntly M Morrison, Daniel M Fines, Janet Peace Babirye, Lily H McCann, Sagar Rawal, Jeffery S Cox, Sarah A Stanley
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010721 (2022)
The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ-independent CD4 T cell based control of M. tuberculosis infection
Externí odkaz:
https://doaj.org/article/27b7d1c2b0c840d09a6ae1ce61049d91
Autor:
Guillaume R. Golovkine, Allison W. Roberts, Huntly M. Morrison, Rafael Rivera-Lugo, Rita M. McCall, Hannah Nilsson, Nicholas E. Garelis, Teresa Repasy, Michael Cronce, Jonathan Budzik, Erik Van Dis, Lauren M. Popov, Gabriel Mitchell, Reena Zalpuri, Danielle Jorgens, Jeffery S. Cox
Publikováno v:
Nature Microbiology. 8:819-832
Autor:
Thomas G W Graham, Claire Dugast-Darzacq, Gina M Dailey, Xammy H Nguyenla, Erik Van Dis, Meagan N Esbin, Abrar Abidi, Sarah A Stanley, Xavier Darzacq, Robert Tjian
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246647 (2021)
Re-opening of communities in the midst of the ongoing COVID-19 pandemic has ignited new waves of infections in many places around the world. Mitigating the risk of reopening will require widespread SARS-CoV-2 testing, which would be greatly facilitat
Externí odkaz:
https://doaj.org/article/d2e00b68e6d249dcbc99fedaffd42153
Autor:
Erik Van Dis, Kimberly M. Sogi, Chris S. Rae, Kelsey E. Sivick, Natalie H. Surh, Meredith L. Leong, David B. Kanne, Ken Metchette, Justin J. Leong, Jacob R. Bruml, Vivian Chen, Kartoosh Heydari, Nathalie Cadieux, Tom Evans, Sarah M. McWhirter, Thomas W. Dubensky, Jr., Daniel A. Portnoy, Sarah A. Stanley
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1435-1447 (2018)
Summary: There are a limited number of adjuvants that elicit effective cell-based immunity required for protection against intracellular bacterial pathogens. Here, we report that STING-activating cyclic dinucleotides (CDNs) formulated in a protein su
Externí odkaz:
https://doaj.org/article/5af82e8c90b24ca6bea46b4f64e9ab0e
Autor:
Huntly M. Morrison, Julia Craft, Rafael Rivera-Lugo, Jeffery R. Johnson, Guillaume R. Golovkine, Claire E. Dodd, Erik Van Dis, Wandy L. Beatty, Shally R. Margolis, Teresa Repasy, Isaac Shaker, Angus Y. Lee, Russell E. Vance, Sarah A. Stanley, Nevan J. Krogan, Dan A. Portnoy, Bennett H. Penn, Jeffery S. Cox
Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2bb7ee444bae4e610492bf8e814abf6
https://doi.org/10.1101/2022.12.29.522180
https://doi.org/10.1101/2022.12.29.522180
Publikováno v:
Annual Review of Immunology. 39:611-637
Infection with Mycobacterium tuberculosis causes >1.5 million deaths worldwide annually. Innate immune cells are the first to encounter M. tuberculosis, and their response dictates the course of infection. Dendritic cells (DCs) activate the adaptive