Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population.

Autor: Sigrid Næss, Benedicte A Lie, Espen Melum, Marita Olsson, Johannes R Hov, Peter J P Croucher, Jochen Hampe, Erik Thorsby, Annika Bergquist, James A Traherne, Erik Schrumpf, Kirsten Muri Boberg, Stefan Schreiber, Andre Franke, Tom H Karlsen

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114486 (2014)

BackgroundGenetic variants within the major histocompatibility complex (MHC) represent the strongest genetic susceptibility factors for primary sclerosing cholangitis (PSC). Identifying the causal variants within this genetic complex represents a maj

Externí odkaz: https://doaj.org/article/d31930296b0d4bbd8ee73bf383fe7ddb

Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.

Autor: Johannes R Hov, Verena Keitel, Jon K Laerdahl, Lina Spomer, Eva Ellinghaus, Abdou ElSharawy, Espen Melum, Kirsten M Boberg, Thomas Manke, Tobias Balschun, Christoph Schramm, Annika Bergquist, Tobias Weismüller, Daniel Gotthardt, Christian Rust, Liesbet Henckaerts, Clive M Onnie, Rinse K Weersma, Martina Sterneck, Andreas Teufel, Heiko Runz, Adolf Stiehl, Cyriel Y Ponsioen, Cisca Wijmenga, Morten H Vatn, IBSEN Study Group, Pieter C F Stokkers, Severine Vermeire, Christopher G Mathew, Benedicte A Lie, Ulrich Beuers, Michael P Manns, Stefan Schreiber, Erik Schrumpf, Dieter Häussinger, Andre Franke, Tom H Karlsen

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12403 (2010)

TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aime

Externí odkaz: https://doaj.org/article/c775ed01a0f746309d30d3ac848ea89e

The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

Autor: Helge Røsjø, Erik Schrumpf, Tom H. Karlsen, Mette Vesterhus, Marius Trøseid, Kristian Holm, Ståle Nygård, Johannes R. Hov, Pål Aukrust, Hanns-Ulrich Marschall, Martin Kummen, Bjørn Moum, Marte Lie Høivik, Jarl Andreas Anmarkrud

Publikováno v: Gut. 66:611-619

Objective Gut microbiota could influence gut, as well as hepatic and biliary immune responses. We therefore thoroughly characterised the gut microbiota in primary sclerosing cholangitis (PSC) compared with healthy controls (HC) and patients with ulce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8b09c9e916690971c304a7ab1cf23d
https://doi.org/10.1136/gutjnl-2015-310500

Liver transplantation in the Nordic countries – An intention to treat and post-transplant analysis from The Nordic Liver Transplant Registry 1982–2013

Autor: Helena Isoniemi, Styrbjörn Friman, Erik Schrumpf, Marie Larsson, Bjarte Fosby, Bo-Göran Ericzon, Christina Wibeck, Heikki Mäkisalo, Arno Nordin, Tom H. Karlsen, Kristian Bjøro, Susanne Keiding, Pål-Dag Line, Aksel Foss, Allan Rasmussen, Michael Olausson, Stein Foss, Leena Toivonen, Annika Bergquist, Espen Melum, Ina Marie Andersen, Truls Sanengen, Krister Höckerstedt, Greg Nowak, Kirsten Muri Boberg, Gunnar Söderdahl, Mette Gotlieb, Maria Castedal, Henrik Gjertsen, William Bennet

Publikováno v: Scandinavian Journal of Gastroenterology
Fosby, B, Melum, E, Bjøro, K, Bennet, W, Rasmussen, A, Andersen, I M, Castedal, M, Olausson, M, Wibeck, C, Gotlieb, M, Gjertsen, H, Toivonen, L, Foss, S, Makisalo, H, Nordin, A, Sanengen, T, Bergquist, A, Larsson, M E, Soderdahl, G, Nowak, G, Boberg, K M, Isoniemi, H, Keiding, S, Foss, A, Line, P-D, Friman, S, Schrumpf, E, Ericzon, B-G, Höckerstedt, K & Karlsen, T H 2015, ' Liver transplantation in the Nordic countries-An intention to treat and post-transplant analysis from The Nordic Liver Transplant Registry 1982-2013 ', Scandinavian Journal of Gastroenterology, vol. 50, no. 6, pp. 797-808 . https://doi.org/10.3109/00365521.2015.1036359

AIM AND BACKGROUND: The Nordic Liver Transplant Registry (NLTR) accounts for all liver transplants performed in the Nordic countries since the start of the transplant program in 1982. Due to short waiting times, donor liver allocation has been made w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50020e9f54e8fa61e264d7b71512530c
http://europepmc.org/articles/PMC4487534

Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis

Autor: William Rosenberg, Kirsten Muri Boberg, Bjørn Moum, Albert Parés, Knut Brabrand, Martti Färkkilä, Helge Røsjø, Fridtjof Lund-Johansen, Trygve Syversveen, Massimo Pinzani, Ståle Nygård, Anders Holm, Odd Helge Gilja, Thor Ueland, Erik Schrumpf, Morten H. Vatn, Ina Marie Andersen, Mette Vesterhus, Cyriel Y. Ponsioen, Kristin Godang, Tom H. Karlsen, Johannes R. Hov, Douglas Thorburn, Sigrid Næss, Francesca Saffioti

Publikováno v: Hepatology (Baltimore, Md.), 62(1), 188-197. John Wiley and Sons Ltd

There is a need to determine biomarkers reflecting disease activity and prognosis in primary sclerosing cholangitis (PSC). We evaluated the prognostic utility of the enhanced liver fibrosis (ELF) score in Norwegian PSC patients. Serum samples were av

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101e4f5accbb4b7175a0bc3acc5162b8
https://doi.org/10.1002/hep.27825