Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Erik, Henke"'
Autor:
David Ascheid, Magdalena Baumann, Jürgen Pinnecker, Mike Friedrich, Daniel Szi-Marton, Cornelia Medved, Maja Bundalo, Vanessa Ortmann, Asli Öztürk, Rajender Nandigama, Katherina Hemmen, Süleymann Ergün, Alma Zernecke, Matthias Hirth, Katrin G. Heinze, Erik Henke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Targeting the supportive tumor microenvironment (TME) is an approach of high interest in cancer drug development. However, assessing TME-targeted drug candidates presents a unique set of challenges. We develop a comprehensive screening platf
Externí odkaz:
https://doaj.org/article/b19449241bfb4bd295570f630d2e8595
Autor:
David Ascheid, Magdalena Baumann, Caroline Funke, Julia Volz, Jürgen Pinnecker, Mike Friedrich, Marie Höhn, Rajender Nandigama, Süleyman Ergün, Bernhard Nieswandt, Katrin G. Heinze, Erik Henke
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract In tumor therapy anti-angiogenic approaches have the potential to increase the efficacy of a wide variety of subsequently or co-administered agents, possibly by improving or normalizing the defective tumor vasculature. Successful implementat
Externí odkaz:
https://doaj.org/article/b1a63164057a41fda92985124212471c
Autor:
Antonio G. Solimando, Matteo C. Da Vià, Patrizia Leone, Paola Borrelli, Giorgio A. Croci, Paula Tabares, Andreas Brandl, Giuseppe Di Lernia, Francesco P. Bianchi, Silvio Tafuri, Torsten Steinbrunn, Alessandra Balduini, Assunta Melaccio, Simona De Summa, Antonella Argentiero, Hilka Rauert-Wunderlich, Maria A. Frassanito, Paolo Ditonno, Erik Henke, Wolfram Klapper, Roberto Ria, Carolina Terragna, Leo Rasche, Andreas Rosenwald, K. Martin Kortüm, Michele Cavo, Domenico Ribatti, Vito Racanelli, Hermann Einsele, Angelo Vacca, Andreas Beilhack
Publikováno v:
Haematologica, Vol 106, Iss 7 (2020)
Interactions of malignant multiple myeloma (MM) plasma cells (MM-cells) with the microenvironment control MM-cell growth, survival, drug-resistance and dissemination. As in MM microvascular density increases in the bone marrow (BM), we investigated w
Externí odkaz:
https://doaj.org/article/c2545760d0c3467b8997b010e53370db
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2020)
Solid tumors are complex organ-like structures that consist not only of tumor cells but also of vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor microenvironment (TME) comprises the larger part of the overall tumo
Externí odkaz:
https://doaj.org/article/9037d43c1e9148bbb71ee0ec94b00c8f
Autor:
Berin Upcin, Erik Henke, Florian Kleefeldt, Helene Hoffmann, Andreas Rosenwald, Ster Irmak-Sav, Huseyin Bertal Aktas, Uwe Rückschloß, Süleyman Ergün
Publikováno v:
Cells, Vol 10, Iss 7, p 1719 (2021)
Blocking tumor vascularization has not yet come to fruition to the extent it was hoped for, as angiogenesis inhibitors have shown only partial success in the clinic. We hypothesized that under-appreciated vascular wall-resident stem and progenitor ce
Externí odkaz:
https://doaj.org/article/d537661bd9ee4c279af165a8476f4bd5
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Pluripotent stem cells give rise to reproductively enabled offsprings by generating progressively lineage-restricted multipotent stem cells that would differentiate into lineage-committed stem and progenitor cells. These lineage-committed stem and pr
Externí odkaz:
https://doaj.org/article/da41e36d0fa144f692a1382e1b89fc1b
Autor:
David A. Scheinberg, Robert Benezra, Ronald G. Blasberg, Peter Smith-Jones, Carlos H. Villa, Michael R. McDevitt, Erik Henke, Freddy E. Escorcia
Supplementary Methods, Figures 1-3 from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744e274e0b77f8de873badc578ddb575
https://doi.org/10.1158/0008-5472.22384244.v1
https://doi.org/10.1158/0008-5472.22384244.v1
Autor:
Jitka Y. Sagiv, Janna Michaeli, Simaan Assi, Inbal Mishalian, Hen Kisos, Liran Levy, Pazzit Damti, Delphine Lumbroso, Lola Polyansky, Ronit V. Sionov, Amiram Ariel, Avi-Hai Hovav, Erik Henke, Zvi G. Fridlender, Zvi Granot
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 562-573 (2015)
Controversy surrounds neutrophil function in cancer because neutrophils were shown to provide both pro- and antitumor functions. We identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflamma
Externí odkaz:
https://doaj.org/article/252c68773cf74eaa9c8907b731a7b5af
Autor:
Rajender Nandigama, Mathias Kallius, Katharina Hemmen, Shaoli Das, Jürgen Pinnecker, David Ascheid, Verena Burkhard, Hla Ali, Daniela Scheld, Sabine Herterich, Alma Zernecke-Madsen, Olaf Penack, Stefan Diller, Kevin Camphausen, Süleyman Ergün, Uma Shankavaram, Katrin Heinze, Freddy E. Escorcia, Erik Henke
Taxanes are known to have a profound effect on endothelial cells and the vasculature even at low doses. Here, we show that taxanes, rather than being anti-angiogenic, function more as vascular disrupting agents (VDAs), although they exert a different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fc274ff712f4eeed848174333f3f0be
https://doi.org/10.1101/2022.07.18.500307
https://doi.org/10.1101/2022.07.18.500307
Autor:
Sandra Vorlova, Gina Blahetek, Ruggero Barbieri, Yvonne Kerstan, Annabelle Rosa, Maja Bundalo, Manuel Egg, Elke Butt, Erik Henke, Lars Dölken, Roland Houben, Bastian Schilling, Utz Fischer, Florian Erhard, Alma Zernecke
Activation of intronic polyadenylation signals results in premature cleavage and polyadenylation (PCPA). The majority of mammalian miRNAs are also located within intronic regions of protein-coding genes and are transcriptionally co-expressed with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3fa6794ad75c63929b52c2ce9853e14
https://doi.org/10.1101/2022.06.01.479622
https://doi.org/10.1101/2022.06.01.479622