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Akademický článek

Effects of Short-Term Sodium Nitrate versus Sodium Chloride Supplementation on Energy and Lipid Metabolism during High-Intensity Intermittent Exercise in Athletes

Autor: Larissa Sarah Blau, Jan Gerber, Armin Finkel, Moritz Lützow, Norbert Maassen, Magdalena Aleksandra Röhrich, Erik Hanff, Dimitrios Tsikas, Vladimir Shushakov, Mirja Jantz

Publikováno v: Applied Sciences, Vol 13, Iss 11, p 6849 (2023)

The aim of this study was to investigate the possible effects of chronic nitrate supplementation on the metabolites of energy metabolism during high-intensity, high-volume intermittent training (HIHVT). In this placebo-controlled double-blind study,

Externí odkaz: https://doaj.org/article/32a92ab0e15043a6a69ec49335379420

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Akademický článek

Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes

Autor: Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff, Arslan Arinc Kayacelebi

Publikováno v: Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-4 (2018)

Abstract NG-Methylation of l-arginine (Arg) residues in certain proteins by protein arginine methyltransferases and subsequent proteolysis yields NG-monomethyl-l-arginine (MMA), NG,NG-dimethyl-l-arginine (asymmetric dimethylarginine, ADMA) and NG,N�

Externí odkaz: https://doaj.org/article/31e08288d9ec4d39a2496ae8a1fc3ed9

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Effects of Short-Term Sodium Nitrate versus Sodium Chloride Supplementation on Energy and Lipid Metabolism during High-Intensity Intermittent Exercise in Athletes

Autor: Jantz, Larissa Sarah Blau, Jan Gerber, Armin Finkel, Moritz Lützow, Norbert Maassen, Magdalena Aleksandra Röhrich, Erik Hanff, Dimitrios Tsikas, Vladimir Shushakov, Mirja

Publikováno v: Applied Sciences; Volume 13; Issue 11; Pages: 6849

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::8bc3e3722207abb55f3b5ffbc8e7229e

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Synthesis of homoagmatine and GC–MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat

Autor: Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff, Björn Redfors, Bibiana Beckmann

Publikováno v: Amino Acids. 52:235-245

Low L-homoarginine (hArg) concentrations in human blood and urine are associated with renal and cardiovascular morbidity and mortality, yet the underlying mechanisms and the biological activities of hArg are elusive. In humans and rats, hArg is metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1e202272644c9ac7a2688cd2e1cd6d
https://doi.org/10.1007/s00726-019-02808-0

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High plasma guanidinoacetate-to-homoarginine ratio is associated with high all-cause and cardiovascular mortality rate in adult renal transplant recipients

Autor: Else van den Berg, M. Y. Said, Isidor Minović, Harry van Goor, Martin H. de Borst, Dimitrios Tsikas, Stephan J. L. Bakker, Adrian Post, Erik Hanff, Arslan Arinc Kayacelebi

Publikováno v: Amino Acids, 51(10-12), 1485-1499. SPRINGER WIEN

l-Arginine:glycine amidinotransferase (AGAT) is the main producer of the creatine precursor, guanidinoacetate (GAA), and l-homoarginine (hArg). We and others previously reported lower levels of circulating and urinary hArg in renal transplant recipie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa95a70a39c4806c1690ea37a6e8ca0
https://doi.org/10.1007/s00726-019-02783-6

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Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection

Autor: Erik Hanff, Dimitrios Tsikas, Gorig Brunner, Alexander Bollenbach

Publikováno v: Amino Acids. 51:961-971

The importance of l-arginine (Arg) and relatives, including l-homoarginine (hArg) and asymmetric dimethylarginine (ADMA), in humans infected with Helicobacter pylori (Hp) is little understood. ADMA is produced by asymmetric dimethylation of the guani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561098caf981ab349c5388d996952c72
https://doi.org/10.1007/s00726-019-02737-y

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Development and validation of GC–MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity

Autor: Stephan Ruben, Stefan Ückert, Dimitrios Tsikas, Constantin von Kaisenberg, Alexander Bollenbach, Anibh M. Das, Dieter Haffner, Martin Kreuzer, Frauke von Versen-Höynck, Erik Hanff, Arslan Arinc Kayacelebi

Publikováno v: Amino Acids. 51:529-547

We developed and validated gas chromatography-mass spectrometry (GC-MS) methods for the simultaneous measurement of amino acids and their metabolites in 10-µL aliquots of human plasma and urine. De novo synthesized trideutero-methyl esters were used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7da7faac6e998ae790a57b46417b87
https://doi.org/10.1007/s00726-018-02688-w

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Enhanced nitric oxide (NO) and decreased ADMA synthesis in pediatric ADHD and selective potentiation of NO synthesis by methylphenidate

Autor: Erik Hanff, Kathrin Jansen, Saskia Pross, Dimitrios Tsikas, Beatrice Hanusch, Christina Carmann, Rainer Georg Siefen, Georg Juckel, Kathrin Drabert, Alexander Bollenbach, Irina Dugave, Tanja Legenbauer, Barbara Emons, Thomas Lücke

Publikováno v: Journal of Clinical Medicine, Vol 9, Iss 1, p 175 (2020)
Journal of Clinical Medicine
Volume 9
Issue 1

Attention deficit hyperactivity disorder (ADHD) is a common pediatric psychiatric disorder, frequently treated with methylphenidate (MPH). Recently, MPH&rsquo
s cardiovascular safety has been questioned by observational studies describing an inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a136e1162e23132c7214ab1f7b4faec
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/7421

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Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure

Autor: Ricarda Grzybowski, Erik Hanff, Rainer H. Böger, D. Tsikas, Kathrin Cordts, Christian Gerloff, Axel Neu, Ali Sasani, Chi-Un Choe, Dirk Isbrandt, Sönke Hornig, Edzard Schwedhelm

Publikováno v: Amino acids 52(1), 73-85 (2019). doi:10.1007/s00726-019-02812-4

Statin-induced myopathy affects more than 10 million people worldwide. But discontinuation of statin treatment increases mortality and cardiovascular events. Recently, l-arginine:glycine amidinotransferase (AGAT) gene was associated with statin-induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe4cb8e5eadb2c2955bef83ca8dd4f8

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