Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Erik, Arner"'
Autor:
Stefan M. Reitzner, Eric B. Emanuelsson, Muhammad Arif, Bogumil Kaczkowski, Andrew TJ. Kwon, Adil Mardinoglu, Erik Arner, Mark A. Chapman, Carl Johan Sundberg
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101857- (2024)
Objective: Long-term high-level exercise training leads to improvements in physical performance and multi-tissue adaptation following changes in molecular pathways. While skeletal muscle baseline differences between exercise-trained and untrained ind
Externí odkaz:
https://doaj.org/article/5555e7b6f3fb4cc487d4127db848bb90
Autor:
Maciej Migdał, Takahiro Arakawa, Satoshi Takizawa, Masaaki Furuno, Harukazu Suzuki, Erik Arner, Cecilia Lanny Winata, Bogumił Kaczkowski
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Elucidating the Transcription Factors (TFs) that drive the gene expression changes in a given experiment is a common question asked by researchers. The existing methods rely on the predicted Transcription Factor Binding Site (TFBS
Externí odkaz:
https://doaj.org/article/cc22b47bb4164d87943f11de15836180
Autor:
Junichiro Takano, Shinsuke Ito, Yixing Dong, Jafar Sharif, Yaeko Nakajima-Takagi, Taichi Umeyama, Yong-Woon Han, Kyoichi Isono, Takashi Kondo, Yusuke Iizuka, Tomohiro Miyai, Yoko Koseki, Mika Ikegaya, Mizuki Sakihara, Manabu Nakayama, Osamu Ohara, Yoshinori Hasegawa, Kosuke Hashimoto, Erik Arner, Robert J. Klose, Atsushi Iwama, Haruhiko Koseki, Tomokatsu Ikawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Here the authors show that a Polycomb Repressive Complex 1 (PRC1) containing PCGF1 prevents excessive loading of transcriptional activators and chromatin remodelers on nascent DNA, allowing proper deposition of nucleosomes immediately after the passa
Externí odkaz:
https://doaj.org/article/cd641a05131948989262bee2e15a9104
Autor:
Alessandro Bonetti, Federico Agostini, Ana Maria Suzuki, Kosuke Hashimoto, Giovanni Pascarella, Juliette Gimenez, Leonie Roos, Alex J. Nash, Marco Ghilotti, Christopher J. F. Cameron, Matthew Valentine, Yulia A. Medvedeva, Shuhei Noguchi, Eneritz Agirre, Kaori Kashi, Samudyata, Joachim Luginbühl, Riccardo Cazzoli, Saumya Agrawal, Nicholas M. Luscombe, Mathieu Blanchette, Takeya Kasukawa, Michiel de Hoon, Erik Arner, Boris Lenhard, Charles Plessy, Gonçalo Castelo-Branco, Valerio Orlando, Piero Carninci
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mammalian genomes encode tens of thousands of ncRNAs that have important roles in regulation of gene expression and chromatin organization. Here, the authors present RADICLseq to map RNA-chromatin interactions in intact nuclei to shed light on these
Externí odkaz:
https://doaj.org/article/3ee35708eeee438bbb6649cdd0169ea5
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009465 (2021)
Drug treatment induces cell type specific transcriptional programs, and as the number of combinations of drugs and cell types grows, the cost for exhaustive screens measuring the transcriptional drug response becomes intractable. We developed DeepCel
Externí odkaz:
https://doaj.org/article/1e922526e25248f6b5086385720b05c1
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009376 (2021)
Regulatory elements control gene expression through transcription initiation (promoters) and by enhancing transcription at distant regions (enhancers). Accurate identification of regulatory elements is fundamental for annotating genomes and understan
Externí odkaz:
https://doaj.org/article/d8d98f21607c4485a344943049cf5b7b
Autor:
Casimiro Castillejo-Lopez, Milos Pjanic, Anna Chiara Pirona, Susanne Hetty, Martin Wabitsch, Claes Wadelius, Thomas Quertermous, Erik Arner, Erik Ingelsson
Publikováno v:
iScience, Vol 20, Iss , Pp 42-59 (2019)
Summary: We combined CAGE sequencing in human adipocytes during differentiation with data from genome-wide association studies to identify an enhancer in the SNX10 locus on chromosome 7, presumably involved in body fat distribution. Using reporter as
Externí odkaz:
https://doaj.org/article/f873f81f776f44f782763874e3c8e5fd
Autor:
Thomas J. Ha, Peter G. Y. Zhang, Remi Robert, Joanna Yeung, Douglas J. Swanson, Anthony Mathelier, Wyeth W. Wasserman, Sujin Im, Masayoshi Itoh, Hideya Kawaji, Timo Lassmann, Carsten O. Daub, Erik Arner, The FANTOM Consortium, Piero Carninci, Yoshihide Hayashizaki, Alistair R. R. Forrest, Daniel Goldowitz
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background The work of the FANTOM5 Consortium has brought forth a new level of understanding of the regulation of gene transcription and the cellular processes involved in creating diversity of cell types. In this study, we extended the anal
Externí odkaz:
https://doaj.org/article/26886484d3af4071954fe82631526e36
Autor:
Tsukasa Kouno, Jonathan Moody, Andrew Tae-Jun Kwon, Youtaro Shibayama, Sachi Kato, Yi Huang, Michael Böttcher, Efthymios Motakis, Mickaël Mendez, Jessica Severin, Joachim Luginbühl, Imad Abugessaisa, Akira Hasegawa, Satoshi Takizawa, Takahiro Arakawa, Masaaki Furuno, Naveen Ramalingam, Jay West, Harukazu Suzuki, Takeya Kasukawa, Timo Lassmann, Chung-Chau Hon, Erik Arner, Piero Carninci, Charles Plessy, Jay W. Shin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Single-cell transcriptomic profiling allows the exploration of cellular heterogeneity but commonly focuses on the 3′-end of the transcript. Here the authors introduce C1 CAGE, which detects the 5′ transcript end in a multiplexed microfluidic syst
Externí odkaz:
https://doaj.org/article/2b223db146cd404e9768769b7c47b35c
Autor:
Iveta Gažová, Lucas Lefevre, Stephen J. Bush, Sara Clohisey, Erik Arner, Michiel de Hoon, Jessica Severin, Lucas van Duin, Robin Andersson, Andreas Lengeling, David A. Hume, Kim M. Summers
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The response of the human acute myeloid leukemia cell line THP-1 to phorbol esters has been widely studied to test candidate leukemia therapies and as a model of cell cycle arrest and monocyte-macrophage differentiation. Here we have employed Cap Ana
Externí odkaz:
https://doaj.org/article/7200a6989408462ca37702c78fd14d54