Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation.

Autor: Erickson EC; Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA., You I; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA., Perry G; Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Dugourd A; Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg University, Heidelberg 69120, Germany., Donovan KA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Crafter C; Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB2 0AA, UK., Johannes JW; Research and Early Development, Oncology R&D, AstraZeneca, Waltham, MA 02451, USA., Williamson S; Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB2 0AA, UK., Moss JI; Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB2 0AA, UK., Ros S; Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB2 0AA, UK., Ziegler RE; Research and Early Development, Oncology R&D, AstraZeneca, Waltham, MA 02451, USA., Barry ST; Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB2 0AA, UK., Fischer ES; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Gray NS; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA., Madsen RR; University College London Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6BT, UK., Toker A; Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Publikováno v: Science signaling [Sci Signal] 2024 Feb 27; Vol. 17 (825), pp. eadf2670. Date of Electronic Publication: 2024 Feb 27.

Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.

Autor: Madsen RR; University College London Cancer Institute, Paul O'Gorman Building, University College London, London, United Kingdom., Erickson EC; Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America., Rueda OM; Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.; NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom., Robin X; SIB Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Basel, Switzerland., Caldas C; Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.; NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom., Toker A; Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America., Semple RK; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom., Vanhaesebroeck B; University College London Cancer Institute, Paul O'Gorman Building, University College London, London, United Kingdom.

Publikováno v: PLoS genetics [PLoS Genet] 2021 Nov 11; Vol. 17 (11), pp. e1009876. Date of Electronic Publication: 2021 Nov 11 (Print Publication: 2021).

Teen-age food habits. A multidimensional analysis.

Autor: Schorr BC, Sanjur D, Erickson EC

Publikováno v: Journal of the American Dietetic Association [J Am Diet Assoc] 1972 Oct; Vol. 61 (4), pp. 415-20.