Výsledky vyhledávání - "Ericka Nevarez-Munoz"

Akademický článek

Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

Autor: Shristi Pawnikar, Brenda S Magenheimer, Keya Joshi, Ericka Nevarez-Munoz, Allan Haldane, Robin L Maser, Yinglong Miao

Publikováno v: eLife, Vol 13 (2024)

Polycystin-1 (PC1) is the protein product of the PKD1 gene whose mutation causes autosomal dominant Polycystic Kidney Disease (ADPKD). PC1 is an atypical G protein-coupled receptor (GPCR) with an autocatalytic GAIN domain that cleaves PC1 into extrac

Externí odkaz: https://doaj.org/article/4f77a5a022894bf284cd5a67536e884c

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Constitutive signaling by the C-terminal fragment of polycystin-1 is mediated by a tethered peptide agonist

Autor: Ericka Nevarez Munoz, Robin L. Maser, Jayalakshmi Ravichandran, Brenda S. Magenheimer

Mutation of the PKD1 gene, encoding polycystin-1 (PC1), is the primary cause of autosomal dominant polycystic kidney disease. PC1 is an 11-transmembrane domain protein that binds and modulates the activity of multiple heterotrimeric G protein familie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a95daabf8ab041c0942a45d7d25bc935
https://doi.org/10.1101/2021.08.20.457171

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