Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ericka N. Oglesby"'
Autor:
Harry A Quigley, Ian F Pitha, Derek S Welsbie, Cathy Nguyen, Matthew R Steinhart, Thao D Nguyen, Mary Ellen Pease, Ericka N Oglesby, Cynthia A Berlinicke, Katherine L Mitchell, Jessica Kim, Joan J Jefferys, Elizabeth C Kimball
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141137 (2015)
PURPOSE:To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. METHODS:We produced IOP increase in CD1 mice and performed unilateral optic nerve cru
Externí odkaz:
https://doaj.org/article/0d0747c61877472a92a3e9b845b4eee6
Autor:
Elizabeth C. Kimball, Mary Ellen Pease, Ericka N. Oglesby, Cathy Nguyen, Julie Schaub, Joan L. Jefferys, Ian Pitha, Harry A. Quigley
Publikováno v:
Experimental Eye Research. 172:78-85
The purpose of this study was to compare younger and older mice after chronic intraocular pressure (IOP) elevation lasting up to 4 days with respect to mitochondrial density, structure, and movement, as well as axonal integrity, in an ex vivo explant
Autor:
Cathy Nguyen, Ericka N. Oglesby, Matthew R. Steinhart, Ian Pitha, Elizabeth C. Kimball, Harry A. Quigley, Mary Ellen Pease
Publikováno v:
Experimental Eye Research. 160:106-115
We developed an explant model of the mouse eye and optic nerve that facilitates the study of retinal ganglion cell axons and mitochondria in the living optic nerve head (ONH) in an ex vivo environment. Two transgenic mouse strains were used, one expr
Autor:
Matthew R. Steinhart, Harry A. Quigley, Joan L. Jefferys, Elizabeth Cone-Kimball, Thomas V. Johnson, Ericka N. Oglesby
Publikováno v:
Investigative Ophthalmology & Visual Science
The irreversible death of retinal ganglion cells (RGCs) is the central common end-point of all optic neuropathies, glaucoma being the most common. The cellular and molecular cascades implicated in glaucomatous RGC loss are extensive,1 and elucidating
Autor:
Ericka N. Oglesby, Elizabeth C. Kimball, Amanda Chow, Julie Schaub, Harry A. Quigley, Ian Pitha, Mary E. Pease
Publikováno v:
Translational Vision Science & Technology
Purpose We evaluated prevention of transforming growth factor β (TGFβ)-induced transdifferentiation of cultured scleral fibroblasts to myofibroblasts by rho-associated protein kinase (ROCK) inhibitors. Additionally, we tested whether local delivery
Autor:
Thao D. Nguyen, Ericka N. Oglesby, Brian C. Oveson, Elizabeth C. Kimball, Mary Ellen Pease, Cathy Nguyen, Matthew R. Steinhart, Harry A. Quigley
Publikováno v:
Experimental Eye Research. 128:129-140
The purpose of this study was to assess the effect of a scleral cross-linking agent on susceptibility to glaucoma damage in a mouse model.CD1 mice underwent 3 subconjunctival injections of 0.5 M glyceraldehyde (GA) in 1 week, then had elevated intrao
Autor:
Shukti Chakravarti, Matthew R. Steinhart, Cathy Nguyen, Elizabeth Cone-Kimball, Mary E. Pease, Harry A. Quigley, Ericka N. Oglesby, Thao D. Nguyen
Publikováno v:
Experimental Eye Research. 119:54-60
The purpose of this research was to study the effects of age and genetic alterations in key connective tissue proteins on susceptibility to experimental glaucoma in mice. We used mice haploinsufficient in the elastin gene (EH) and mice without both a
Autor:
Justin Hanes, Ian Pitha, Yoo Chun Kim, Elizabeth C. Kimball, Harry A. Quigley, Julie Schaub, Mary E. Pease, Ericka N. Oglesby, Jie Fu, Qi Hu
Publikováno v:
Translational Vision Science & Technology
Purpose To determine if one injection of a sustained release formulation of dorzolamide in biodegradable microparticles (DPP) reduces retinal ganglion cell (RGC) loss in a rat model of glaucoma. Methods We injected either DPP or control microparticle
Autor:
Michael R. Steele, Wendi S. Lambert, David J. Calkins, Denise M. Inman, Philip J. Horner, Monica L. Vetter, Nicholas Marsh-Armstrong, Brian Buckingham, Ericka N. Oglesby
Publikováno v:
The Journal of Neuroscience. 28:2735-2744
Glaucoma is characterized by retinal ganglion cell (RGC) pathology and a progressive loss of vision. Previous studies suggest RGC death is responsible for vision loss in glaucoma, yet evidence from other neurodegenerative diseases suggests axonal deg
Autor:
Ericka N. Oglesby, Joan J. Jefferys, Mary Ellen Pease, Elizabeth C. Kimball, Thao D. Nguyen, Harry A. Quigley, Jessica Kim, Ian Pitha, Cathy Nguyen, Matthew R. Steinhart, Derek S. Welsbie, Katherine L. Mitchell, Cynthia Berlinicke
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 10, p e0141137 (2015)
PLoS ONE, Vol 10, Iss 10, p e0141137 (2015)
Purpose To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. Methods We produced IOP increase in CD1 mice and performed unilateral optic nerve cru