Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Erick Singley"'
Autor:
Sofia Bouhlal, April N. Le, Mehdi Farokhnia, Lorenzo Leggio, Erick Singley, Mikela B. Sheskier, Timmy Ton, Zhen Zhao, Mary R. Lee
Publikováno v:
Neuropharmacology. 137:230-239
Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the nervous system, plays an important role in biobehavioral processes that regulate alcohol seeking, food intake, and stress response. The metabotropic GABA-B receptor has been
Autor:
Sandrine Pirard, Lorenzo Leggio, Kayla N. Ellefsen, Marilyn A. Huestis, Sofia Bouhlal, David A. Gorelick, Mikela B. Sheskier, Erick Singley
Publikováno v:
Drug and alcohol dependence. 180
Background Food intake and use of drugs of abuse like cocaine share common central and peripheral physiological pathways. Appetitive hormones play a major role in regulating food intake; however, little is known about the effects of acute cocaine adm
Publikováno v:
Journal of Visualized Experiments.
Operant oral self-administration methods are commonly used to study the reinforcing properties of ethanol in animals. However, the standard methods require saccharin/sucrose fading, water deprivation and/or extended training to initiate operant respo
Autor:
Matthew Solomon, Markus Heilig, Andrew Holmes, David M. Lovinger, Rainer Spanagel, Rose-Marie Karlsson, Louise Adermark, Kohichi Tanaka, Erick Singley, Stephanie Perreau-Lenz, Anna Molander
Publikováno v:
Neuropharmacology. 63:181-189
A hyperglutamatergic state has been hypothesized to drive escalation of alcohol intake. This hypothesis predicts that an impairment of glutamate clearance through inactivation of the astrocytic glutamate transporter, GLAST (EAAT1), will result in esc
Autor:
David T. George, Erick Singley, Julie Usala, John C. Umhau, Christopher B. Geyer, Melanie L. Schwandt, Markus Heilig
Publikováno v:
Neuropsychopharmacology. 36:1178-1186
Modulation of alcohol craving induced by challenge stimuli may predict the efficacy of new pharmacotherapies for alcoholism. We evaluated two pharmacological challenges, the α(2)-adrenergic antagonist yohimbine, which reinstates alcohol seeking in r
Publikováno v:
Psychopharmacology. 209:103-111
Reduced voluntary alcohol consumption was recently found in neurokinin-1 receptor (NK1R)-deficient (KO) mice. It remains unknown whether this reflects developmental effects or direct regulation of alcohol consumption by NK1R:s, and whether the reduce
Autor:
Robert L. Eskay, Markus Heilig, Andrea Cippitelli, Erick Singley, Ruslan Damadzic, Annika Thorsell, Roberto Ciccocioppo
Background A dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in the development of excessive alcohol consumption and dependence. The aim of the present study was to evaluate whether the CRH system is also recruit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f267bdec4efacd1c420cb3eacb8f9b
https://europepmc.org/articles/PMC3242882/
https://europepmc.org/articles/PMC3242882/
Autor:
Andrea Goldstein, Markus Heilig, Annika Thorsell, Robert L. Eskay, Erick Singley, Kate Frankola, Ruslan Damadzic, Andrea Cippitelli
Publikováno v:
Biological psychiatry. 67(9)
Background Glutamatergic neurotransmission has been implicated in mechanisms of alcohol-induced neurodegeneration and cognitive impairment, but the underlying mechanism remains unknown. Here, we examined whether the group II metabotropic glutamate re
Autor:
Stephanie S. O'Malley, Vijay A. Ramchandani, Raafat Bishai, David T. George, Cheryl L. Jones, Christopher B. Geyer, Debra Hill, David Herion, Robert R. Rawlings, Erick Singley, Markus Heilig, George Kunos, David E. Spero, Monte J. Phillips, Jacqueline Hersh
Publikováno v:
Psychopharmacology. 208(1)
There is an extensive literature showing that the CB(1) cannabinoid receptor antagonist rimonabant (SR141716) decreases alcohol consumption in animals, but little is known about its effects in human alcohol drinkers.In this study, 49 nontreatment-see
Autor:
Erick Singley, Valentina Vengeliene, Mariel Lifshitz, John C. Umhau, Melanie L. Schwandt, Lauren J. Adams, Reza Momenan, David T. George, Jun Shen, Linda Doty, Markus Heilig, Daniel W. Hommer, Rainer Spanagel, Yan Zhang
Publikováno v:
Archives of General Psychiatry. 67:1069
Acamprosate is approved for the treatment of alcoholism, but its mechanism of action remains unclear. Results of animal studies suggest that a persistent hyperglutamatergic state contributes to the pathogenesis of alcoholism and that acamprosate may