Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Erick K. Dufour"'
Publikováno v:
Protein Science. 14:303-315
Furin proteolytically cleaves a wide variety of proprotein substrates mainly within the trans-Golgi network (TGN) but also at the cell membrane and in endosomal compartments where pH is more acidic. Incorporation of furin recognition sequences within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a36dfe2e0e938922e2dbd739a9cfb2
https://doi.org/10.1110/ps.04843305
https://doi.org/10.1110/ps.04843305
Autor:
Donald E. Woods, Julie Héroux, André M. Cantin, Erick K. Dufour, Diane Cloutier, Richard Leduc
Publikováno v:
Journal of Aerosol Medicine. 15:141-148
Cystic fibrosis patients demonstrate an increased susceptibility to bacterial lung infections. Airway infiltration by neutrophils will then lead to an increase in human leukocyte elastase (HLE) within the extracellular compartment, thereby producing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f0b850839b66b87af35a8562f11760
https://doi.org/10.1089/089426802320282266
https://doi.org/10.1089/089426802320282266
Autor:
Pierre Lavigne, Lyne Bissonnette, Erick K. Dufour, Paul C.R. Hopkins, Jean-Bernard Denault, Richard Leduc
Publikováno v:
Journal of Biological Chemistry. 276:38971-38979
A series of mutants incorporating furin recognition sequences within the P6-P1 region of the reactive site loop of alpha(1)-antitrypsin were constructed. Variants containing different combinations of basic residues in the P1, P2, P4, and P6 positions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2e86a55539b1b179e9971d749a9e01
https://doi.org/10.1074/jbc.m102959200
https://doi.org/10.1074/jbc.m102959200
Publikováno v:
American journal of respiratory cell and molecular biology. 27(6)
alpha1 Proteinase inhibitor (alpha1PI), a natural inhibitor of the serine proteinase leukocyte elastase, is also an intravenous therapeutic agent used to treat hereditary emphysema and may be useful in other respiratory disorders. However, to achieve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46f4e497d47af9936f9b6463f575f8f
https://pubmed.ncbi.nlm.nih.gov/12444025
https://pubmed.ncbi.nlm.nih.gov/12444025
Autor:
Richard Leduc, M. Luisa Iruela-Arispe, Juan Carlos Rodríguez-Manzaneque, Erick K. Dufour, Allison B. Milchanowski
Publikováno v:
The Journal of biological chemistry. 275(43)
METH-1/ADAMTS1 is a member of a newly described family of genes that contain metalloprotease, disintegrin, and thrombospondin-like motifs. We have recently shown that METH-1 protein is a potent inhibitor of angiogenesis. Here, we demonstrate that sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846b23972ea8ed58c7430b6465d74e6c
https://pubmed.ncbi.nlm.nih.gov/10944521
https://pubmed.ncbi.nlm.nih.gov/10944521
Publikováno v:
FEBS Letters. (1):41-46
Recent studies have demonstrated that a serpin variant, alpha1-antitrypsin Portland (AT-PDX), can inhibit the mammalian convertase furin. Here, we examine the mechanism by which this inhibition takes place. We find that furin, which does not belong t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b74b579d01aa52ceb3d28f50f6c708