Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial

Autor: Katie O’Hearn, Kusum Menon, Lisa Albrecht, Karin Amrein, Philip Britz-McKibbin, Florence Cayouette, Karen Choong, Jennifer Ruth Foster, Dean A. Fergusson, Alejandro Floh, Patricia Fontela, Pavel Geier, Elaine Gilfoyle, Gonzalo Garcia Guerra, Anna Gunz, Erick Helmeczi, Ali Khamessan, Ari R. Joffe, Laurie Lee, Lauralyn McIntyre, Srinivas Murthy, Simon J. Parsons, Tim Ramsay, Lindsay Ryerson, Marisa Tucci, Dayre McNally, the Canadian Critical Care Trials Group

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-14 (2024)

Abstract Background The rate of vitamin D deficiency (VDD) in critically ill children worldwide has been estimated at 50%. These children are at risk of multiple organ dysfunction, chronic morbidity, and decreased health related quality of life (HRQL

Externí odkaz: https://doaj.org/article/40ecd62e39304633b75bfcc314fd918c

A high-throughput platform for the rapid screening of vitamin D status by direct infusion-MS/MS

Autor: Erick Helmeczi, Eric Fries, Lauren Perry, Karen Choong, Katie O’Hearn, Dayre McNally, Philip Britz-McKibbin

Publikováno v: Journal of Lipid Research, Vol 63, Iss 5, Pp 100204- (2022)

Vitamin D is an important fat-soluble prohormone with pleiotropic effects on human health, such as immunomodulation of the innate and adaptive immune system. There is an unmet clinical need for a rapid screening platform for 25-hydroxyvitamin D (25OH

Externí odkaz: https://doaj.org/article/622d00d8ea4b4538bfbb52ff6838cfeb

Low dose lithium supplementation activates Wnt/β-catenin signalling and increases bone OPG/RANKL ratio in mice

Autor: Val A. Fajardo, Panagiota Klentrou, Nigel Kurgan, Brian D. Roy, Kirsten N. Bott, Ian D. Brindle, W. Erick Helmeczi

Publikováno v: Biochemical and biophysical research communications. 511(2)

Lithium, a well-known inhibitor of glycogen synthase kinase-3β (GSK3β), can improve bone formation by activating the Wnt/β-catenin signalling pathway. However, most studies have used higher doses of lithium, which potentially have adverse effects.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7db0c4499d3678af42cc819f751681
https://pubmed.ncbi.nlm.nih.gov/30791983

Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial.

Autor: O'Hearn, Katie¹ (AUTHOR), Menon, Kusum^1,2 (AUTHOR), Albrecht, Lisa¹ (AUTHOR), Amrein, Karin³ (AUTHOR), Britz-McKibbin, Philip⁴ (AUTHOR), Cayouette, Florence⁵ (AUTHOR), Choong, Karen⁶ (AUTHOR), Foster, Jennifer Ruth^7,8 (AUTHOR), Fergusson, Dean A.^9,10,11 (AUTHOR), Floh, Alejandro^12,13 (AUTHOR), Fontela, Patricia^14,15 (AUTHOR), Geier, Pavel^1,2 (AUTHOR), Gilfoyle, Elaine^12,16 (AUTHOR), Guerra, Gonzalo Garcia^17,18,19 (AUTHOR), Gunz, Anna²⁰ (AUTHOR), Helmeczi, Erick⁴ (AUTHOR), Khamessan, Ali²¹ (AUTHOR), Joffe, Ari R.^19,22 (AUTHOR), Lee, Laurie^23,24 (AUTHOR), McIntyre, Lauralyn^10,25 (AUTHOR)

Publikováno v: Trials. 9/19/2024, Vol. 25 Issue 1, p1-14. 14p.

Development of a general acid method for the digestion of gold ore samples together with a comparison of extraction solvents for gold and determination by microwave-induced plasma-atomic emission spectrometry (MIP-AES).

Autor: Helmeczi, Wryan, Helmeczi, Erick, Baker, Laura A., Wang, Yong, Brindle, Ian D.

Publikováno v: JAAS (Journal of Analytical Atomic Spectrometry); Aug2018, Vol. 33 Issue 8, p1336-1344, 9p